{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:49:45Z","timestamp":1792799385119,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,6,29]],"date-time":"2014-06-29T00:00:00Z","timestamp":1404000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet & Gyne"],"published-print":{"date-parts":[[2014,8]]},"abstract":"ABSTRACT<\/jats:title>Objective<\/jats:title>To investigate longitudinal changes in maternal hemodynamics from the first trimester onward in women who develop pre\u2010eclampsia (PE<\/jats:styled-content>) or gestational hypertension (GH<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>This was a prospective longitudinal study of singleton pregnancies identified by screening at 11\u2009+\u20090 to 13\u2009+\u20096 weeks' gestation as being at high risk for PE<\/jats:styled-content>. Measurements of augmentation index (AIx<\/jats:styled-content>), pulsed wave velocity (PWV<\/jats:styled-content>) and aortic systolic blood pressure (SBPao<\/jats:styled-content>) were taken every 4 weeks until delivery. Values were compared between women who developed preterm PE<\/jats:styled-content> requiring delivery before 37 weeks, term PE<\/jats:styled-content> or GH<\/jats:styled-content>, and those who remained normotensive.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 1198 observations were recorded in 245 women, including 181 who were normotensive, 22 with preterm PE<\/jats:styled-content>, 22 with term PE<\/jats:styled-content> and 20 with GH<\/jats:styled-content>. In the normotensive group, there was a U\u2010shaped relationship between AIx<\/jats:styled-content> and gestational age with a trough at 25 weeks' gestation, whereas changes in levels of PWV<\/jats:styled-content> or SBPao<\/jats:styled-content> were minimal, with a mild increase from 25 and 30 weeks' gestation onward, respectively. In the GH<\/jats:styled-content> and preterm PE<\/jats:styled-content> groups, compared to the normotensive group, SBPao<\/jats:styled-content> was higher and the difference did not change significantly with gestational age. In the term PE<\/jats:styled-content> group, SBPao<\/jats:styled-content> did not differ significantly from that in the normotensive group. In the preterm PE<\/jats:styled-content> group compared to the normotensive group, PWV<\/jats:styled-content> and AIx<\/jats:styled-content> were significantly higher from 16\u201317 weeks' gestation onward and the difference increased with gestational age in both cases. In the term PE<\/jats:styled-content> and GH<\/jats:styled-content> groups, PWV<\/jats:styled-content> and AIx<\/jats:styled-content> did not differ significantly from normal.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>This study describes temporal changes in AIx<\/jats:styled-content>, PWV<\/jats:styled-content> and SBPao<\/jats:styled-content> in normotensive pregnant women and in women who develop PE<\/jats:styled-content> or GH<\/jats:styled-content>. Copyright \u00a9 2014 ISUOG. Published by John Wiley & Sons Ltd<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.13367","type":"journal-article","created":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T18:55:04Z","timestamp":1395341704000},"page":"197-204","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Longitudinal changes in maternal hemodynamics in a population at risk for pre\u2010eclampsia"],"prefix":"10.1002","volume":"44","author":[{"given":"A.","family":"Khalil","sequence":"first","affiliation":[{"name":"Department of Fetal Medicine, Institute for Women's Health University College London Hospitals London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Garcia\u2010Mandujano","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine, Institute for Women's Health University College London Hospitals London UK"},{"name":"Department of Fetal Medicine King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Maiz","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Obstetrics and Gynecology Service, BioCruces Health Research Institute, Hospital Universitario Cruces University of the Basque Country (UPV\/EHU) Barakaldo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Elkhouli","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine, Institute for Women's Health University College London Hospitals London UK"},{"name":"Department of Fetal Medicine King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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