{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T00:56:38Z","timestamp":1768092998682,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,1,27]],"date-time":"2015-01-27T00:00:00Z","timestamp":1422316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess fetal cardiac function in first\u2010trimester trisomy\u201021 fetuses as compared with fetuses with other aneuploidies, euploid fetuses with cardiac defects or isolated increased nuchal translucency (NT) and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>During a 2.5\u2010year period, NT, ductus venosus (<jats:styled-content style=\"fixed-case\">DV<\/jats:styled-content>) blood flow, diastolic filling time, early filling time, tricuspid flow, tricuspid and mitral valve E\/A velocity ratios, left ventricle shortening fraction, left myocardial performance index and fetal heart rate were assessed in fetuses with a crown\u2013rump length between 45 and 84\u2009mm undergoing chorionic villus sampling at our center. Cardiac parameters among study groups were compared with the use of 95% <jats:styled-content style=\"fixed-case\">CIs<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study population comprised 28 fetuses with trisomy 21, 25 with other aneuploidies, 94 euploid fetuses with abnormal findings (27 with cardiac defects, 31 with other structural anomalies and 36 with isolated increased <jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>) and 271 controls. Trisomy\u201021 fetuses showed signs of diastolic dysfunction such as increased <jats:styled-content style=\"fixed-case\">DV<\/jats:styled-content> pulsatility index and E\/A ratios together with a higher prevalence of tricuspid regurgitation. However, no differences were found in euploid fetuses with cardiac defects or isolated increased <jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>No signs of cardiac dysfunction were observed in euploid fetuses with increased <jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content> or cardiac defects, while in trisomy\u201021 fetuses signs of diastolic dysfunction could be potentially attributed to volume overload. Copyright \u00a9 2014 ISUOG. 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