{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T18:01:16Z","timestamp":1773424876505,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,9]],"date-time":"2015-03-09T00:00:00Z","timestamp":1425859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Limburg Clinical Research Project, Hasselt University Belgium"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2015,4]]},"abstract":"ABSTRACT<\/jats:title>Objective<\/jats:title>To compare functional characteristics of maternal thoraco\u2010abdominal arteries and veins in proteinuric and non\u2010proteinuric hypertension in pregnancy.<\/jats:p><\/jats:sec>Methods<\/jats:title>This retrospective study included women with singleton pregnancies during the third trimester, which were either uncomplicated or complicated with different clinical types of hypertension: non\u2010proteinuric gestational hypertension (GH<\/jats:styled-content>), early\u2010onset pre\u2010eclampsia (PE<\/jats:styled-content>) diagnosed\u2009<\u200934 weeks or late\u2010onset PE<\/jats:styled-content> diagnosed \u2265\u200934\u2009weeks. Demographic maternal and neonatal data were recorded, together with maternal serum and urine analytes. All women underwent standardized automated blood\u2010pressure measurement, together with non\u2010invasive impedance cardiography (ICG<\/jats:styled-content>), for measurement of cardiac output (CO<\/jats:styled-content>), aortic flow velocity index (VI<\/jats:styled-content>) and aortic flow acceleration index (ACI<\/jats:styled-content>). A standardized combined Doppler\u2013electrocardiography assessment of maternal venous hemodynamics was performed to measure renal interlobar vein impedance index (RIVI<\/jats:styled-content>), hepatic vein impedance index (HVI<\/jats:styled-content>) and venous pulse transit time (VPTT<\/jats:styled-content>) in liver and kidneys. Finally, resistance index (RI<\/jats:styled-content>), pulsatility index (PI<\/jats:styled-content>) and arterial pulse transit time (APTT<\/jats:styled-content>) were measured in the uterine arcuate arteries. Mann\u2013Whitney U<\/jats:italic>\u2010tests and Fisher's exact tests were used for intergroup comparisons, and linear dependence between variables was assessed using Pearson's correlation coefficient (r<\/jats:italic>).<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 150 pregnancies were evaluated: 22 with uncomplicated pregnancy, 41 GH<\/jats:styled-content>, 31 early PE<\/jats:styled-content> and 56 late PE<\/jats:styled-content>. Aortic VI<\/jats:styled-content> and ACI<\/jats:styled-content> were lower in GH<\/jats:styled-content>, early PE<\/jats:styled-content> and late PE<\/jats:styled-content> than in uncomplicated pregnancy. Both early PE<\/jats:styled-content> and late PE<\/jats:styled-content> differed from GH<\/jats:styled-content> by having shorter APTT<\/jats:styled-content> in the uterine arcuate arteries and higher RIVI<\/jats:styled-content>. Hemodynamic abnormalities were most pronounced in early PE<\/jats:styled-content>, during which uterine arcuate artery RI<\/jats:styled-content> was higher and VPTT<\/jats:styled-content> in kidneys was shorter than in late PE<\/jats:styled-content>. There was a significant correlation between degree of proteinuria and RIVI<\/jats:styled-content> for the left\n(r<\/jats:italic>\u2009=\u20090.381) and right (r<\/jats:italic>\u2009=\u20090.347) kidney in late PE<\/jats:styled-content>, but this was not true for early PE<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>There is a gradient of worsening arterial and venous hemodynamic abnormalities from GH<\/jats:styled-content> to late PE<\/jats:styled-content> and then to early PE<\/jats:styled-content>. Venous hemodynamic abnormalities are present only in PE<\/jats:styled-content>, with a linear correlation between proteinuria and RIVI<\/jats:styled-content> in late PE<\/jats:styled-content>. The role of the maternal venous compartment in the pathophysiology and etiology of PE<\/jats:styled-content>\u2010related symptoms may be much more important than considered at present. Copyright \u00a9 2014 ISUOG. Published by John Wiley & Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.13427","type":"journal-article","created":{"date-parts":[[2014,6,2]],"date-time":"2014-06-02T17:43:19Z","timestamp":1401730999000},"page":"421-426","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Maternal venous Doppler characteristics are abnormal in pre\u2010eclampsia but not in gestational hypertension"],"prefix":"10.1002","volume":"45","author":[{"given":"W.","family":"Gyselaers","sequence":"first","affiliation":[{"name":"Department of Obstetrics & Gynaecology Ziekenhuis Oost\u2010Limburg Genk Belgium"},{"name":"Department of Physiology Hasselt University Hasselt Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Staelens","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynaecology Ziekenhuis Oost\u2010Limburg Genk Belgium"},{"name":"Department of Medicine and Life 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