{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T07:43:59Z","timestamp":1788853439757,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T00:00:00Z","timestamp":1429833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Tuberous sclerosis complex (<jats:styled-content style=\"fixed-case\">TSC<\/jats:styled-content>) is a genetic disorder characterized by abnormal cell proliferation and tumor growth in a number of organ systems, primarily the brain, kidneys, eyes and heart. Clinical symptoms vary according to the location of the tumor. The most common disorders are seizures, neurodevelopmental disorders, renal failure and arrhythmias. <jats:styled-content style=\"fixed-case\">TSC<\/jats:styled-content> was found to be influenced by inhibitors of the protein kinase mammalian target of rapamycin (<jats:styled-content style=\"fixed-case\">mTOR<\/jats:styled-content>), which regulates abnormal cellular proliferation. <jats:styled-content style=\"fixed-case\">mTOR<\/jats:styled-content> inhibitors have been studied effectively in patients with subependymal giant\u2010cell astrocytomas and renal angiolipomas in the context of <jats:styled-content style=\"fixed-case\">TSC<\/jats:styled-content>. We describe a prenatally diagnosed case of giant rhabdomyoma, due to right ventricular outflow tract obstruction, which presented as a duct\u2010dependent lesion. Postnatal treatment with the <jats:styled-content style=\"fixed-case\">mTOR<\/jats:styled-content> inhibitor everolimus initiated significant regression of the cardiac tumor. This finding suggests that <jats:styled-content style=\"fixed-case\">mTOR<\/jats:styled-content> inhibitor therapy is an option for giant rhabdomyomas that develop in the neonatal period. Copyright \u00a9 2014 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p>","DOI":"10.1002\/uog.13434","type":"journal-article","created":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T10:26:33Z","timestamp":1402395993000},"page":"618-621","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Prenatal diagnosis of giant cardiac rhabdomyoma in tuberous sclerosis complex: a new therapeutic option with everolimus"],"prefix":"10.1002","volume":"45","author":[{"given":"E.","family":"Mlczoch","sequence":"first","affiliation":[{"name":"Pediatric Heart Center, Department of Pediatrics and Adolescent Medicine, Division for Pediatric Cardiology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Hanslik","sequence":"additional","affiliation":[{"name":"Pediatric Heart Center, Department of Pediatrics and Adolescent Medicine, Division for Pediatric Cardiology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Luckner","sequence":"additional","affiliation":[{"name":"Pediatric Heart Center, Department of Pediatrics and Adolescent Medicine, Division for Pediatric Cardiology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Kitzm\u00fcller","sequence":"additional","affiliation":[{"name":"Pediatric Heart Center, Department of Pediatrics and Adolescent Medicine, Division for Pediatric Cardiology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Prayer","sequence":"additional","affiliation":[{"name":"Department of Radiology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Michel\u2010Behnke","sequence":"additional","affiliation":[{"name":"Pediatric Heart Center, Department of Pediatrics and Adolescent Medicine, Division for Pediatric Cardiology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,24]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1001671"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra055323"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05117.x"},{"key":"e_1_2_3_5_1","first-page":"39","article-title":"Prenatal diagnosis of giant cardiac rhabdomyoma with fetal hydrops in tuberous sclerosis","volume":"7","author":"Schlaegel F","year":"2013","journal-title":"J Prenat Med"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.68.3.367"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5264"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201402"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2008.09.013"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073807307093"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(03)00677-5"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-003-0590-4"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951109992046"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-0504"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.825"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.037226"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2013.03.002"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-2910"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/08880018.2012.734896"}],"container-title":["Ultrasound in Obstetrics &amp; 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