{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:00:47Z","timestamp":1777417247043,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,9,10]],"date-time":"2014-09-10T00:00:00Z","timestamp":1410307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet & Gyne"],"published-print":{"date-parts":[[2014,10]]},"abstract":"ABSTRACT<\/jats:title>Objectives<\/jats:title>To assess myocardial performance index measured by conventional Doppler (MPI<\/jats:styled-content>) and by tissue Doppler imaging (MPI<\/jats:styled-content>\u2032) at 18\u2009weeks' gestation in monochorionic diamniotic twins for the prediction of twin\u2010to\u2010twin transfusion syndrome (TTTS<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>This was a single\u2010center observational study of 100 uncomplicated monochorionic diamniotic twin pregnancies attending the twin pregnancy clinic at the University Hospital Spedali Civili of Brescia from 2009 to 2012. MPI<\/jats:styled-content> and MPI<\/jats:styled-content>\u2032 were obtained from the left (LV<\/jats:styled-content>) and right (RV<\/jats:styled-content>) ventricles of each twin at around 18\u2009weeks of gestation (range, 17\u2009+\u20091 to 19\u2009+\u20094\u2009weeks) and fortnightly thereafter. Cases which later developed TTTS<\/jats:styled-content> formed the study group, and the remaining controls were subdivided into those continuing as uncomplicated pregnancies and those which later developed selective intrauterine growth restriction (sIUGR<\/jats:styled-content>). Data were analyzed by receiver\u2013operating characteristics curve analysis and\u2009univariate and multivariable logistic regression.<\/jats:p><\/jats:sec>Results<\/jats:title>Of the 100 pregnancies, 88 were controls (84 uncomplicated and four developed sIUGR<\/jats:styled-content>) and 12 developed TTTS<\/jats:styled-content>. RV\u2010MPI<\/jats:styled-content> and LV\u2010MPI<\/jats:styled-content>, and LV\u2010MPI<\/jats:styled-content>\u2032 were significantly higher in future TTTS<\/jats:styled-content> recipients than in controls, while RV\u2010MPI<\/jats:styled-content>\u2032 was significantly lower in donors. RV\u2010MPI<\/jats:styled-content> and LV\u2010MPI<\/jats:styled-content> and LV\u2010MPI<\/jats:styled-content>\u2032 were found to be predictive indicators in pregnancies that had not yet developed TTTS<\/jats:styled-content>. Their negative predictive values were\u2009>\u200990%, and their specificities\u2009>\u200980%. The best performing index was LV\u2010MPI<\/jats:styled-content>\u2032, with a sensitivity of 91.7% and specificity of 88.6%.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Before diagnosis of TTTS<\/jats:styled-content>, the cardiac function (as assessed by MPI<\/jats:styled-content> and MPI<\/jats:styled-content>\u2032) of the future donor twin is not grossly abnormal, but that of the recipient is abnormal. We identified cardiac indices predictive of the subsequent development of TTTS<\/jats:styled-content>, and suggest a possible role of these indices in planning the follow\u2010up of monochorionic diamniotic twin pregnancies. Copyright \u00a9 2014 ISUOG. Published by John Wiley & Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.13442","type":"journal-article","created":{"date-parts":[[2014,6,11]],"date-time":"2014-06-11T18:36:43Z","timestamp":1402511803000},"page":"434-440","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Fetal cardiac parameters for prediction of twin\u2010to\u2010twin transfusion syndrome"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7793-714X","authenticated-orcid":false,"given":"C.","family":"Zanardini","sequence":"first","affiliation":[{"name":"Maternal\u2010Fetal Medicine Unit, Department of Obstetrics and Gynaecology University of Brescia Brescia Italy"},{"name":"PhD Programme in Reproduction and Development University of Trieste Trieste Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Prefumo","sequence":"additional","affiliation":[{"name":"Maternal\u2010Fetal Medicine Unit, Department of Obstetrics and Gynaecology University of Brescia Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Fichera","sequence":"additional","affiliation":[{"name":"Maternal\u2010Fetal Medicine Unit, Department of Obstetrics and Gynaecology University of Brescia Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Botteri","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Biostatistics European Institute of Oncology Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Frusca","sequence":"additional","affiliation":[{"name":"Maternal\u2010Fetal Medicine Unit, Department of Obstetrics and Gynaecology University of Brescia Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7200292"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2010.09.375"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31819c9f66"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2011-0208"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000338003"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000146896.20317.59"},{"key":"e_1_2_5_8_1","article-title":"Diastolic cardiac pathology and clinical twin\u2010twin transfusion syndrome in monochorionic\/diamniotic twins","volume":"205","author":"Moon\u2010Grady AJ","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.02.044"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2011.04.010"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5292"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.313.7059.744"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10117"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5211"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2009.02.005"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/379792"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.02.051"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.01.051"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3947"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6238"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6230"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3819"},{"key":"e_1_2_5_24_1","volume-title":"Management of Monochorionic Twin Pregnancy","author":"Royal College of Obstetricians and Gynaecologists","year":"2008"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2010.12.045"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8802"}],"container-title":["Ultrasound in Obstetrics & Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.13442","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.13442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T16:32:12Z","timestamp":1696523532000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.13442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,10]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1002\/uog.13442"],"URL":"https:\/\/doi.org\/10.1002\/uog.13442","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,10]]},"assertion":[{"value":"2014-04-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-06-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-09-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}