{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:45:17Z","timestamp":1790801117099,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T00:00:00Z","timestamp":1429833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet & Gyne"],"published-print":{"date-parts":[[2015,5]]},"abstract":"ABSTRACT<\/jats:title>Objective<\/jats:title>To evaluate the role of prenatal prognostic markers obtained routinely by ultrasound examination and magnetic resonance imaging (MRI<\/jats:styled-content>) in the prediction of development of postnatal pulmonary arterial hypertension (PAH<\/jats:styled-content>) in isolated congenital diaphragmatic hernia (CDH<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>One hundred and ten cases of isolated CDH<\/jats:styled-content> were referred to our fetal medicine unit between January 2004 and April 2013. Mortality and morbidity rates were reviewed for those presenting with postnatal PAH<\/jats:styled-content>. The following prenatal markers were evaluated as potential predictive factors of PAH<\/jats:styled-content>: liver position, side of the CDH<\/jats:styled-content> defect, lung area to head circumference ratio (LHR<\/jats:styled-content>) and observed\/expected LHR<\/jats:styled-content> (o\/e\u2010LHR<\/jats:styled-content>), which were measured by ultrasound, and observed\/expected total fetal lung volume (o\/e\u2010TFLV<\/jats:styled-content>), which was measured by MRI<\/jats:styled-content>. Univariable logistic regression was used to assess associations.<\/jats:p><\/jats:sec>Results<\/jats:title>PAH<\/jats:styled-content> was significantly associated with perinatal mortality and morbidity (P<\/jats:italic> < 0.001). The occurrence of PAH<\/jats:styled-content> decreased significantly with an increasing LHR<\/jats:styled-content>, o\/e\u2010LHR<\/jats:styled-content> and o\/e\u2010TFLV<\/jats:styled-content> and was significantly increased for cases with an intrathoracic liver, but not for those with right\u2010sided defects. Univariable regression revealed that o\/e\u2010TFLV<\/jats:styled-content> (odds ratio (OR<\/jats:styled-content>), 0.9 (95% CI<\/jats:styled-content>, 0.86\u20130.95); P<\/jats:italic> < 0.05 for percentage unit change in o\/e), LHR<\/jats:styled-content> (OR<\/jats:styled-content>, 0.19 (95% CI<\/jats:styled-content>, 0.09\u20130.40); P<\/jats:italic> < 0.05 for unit change), o\/e\u2010LHR<\/jats:styled-content> (OR<\/jats:styled-content>, 0.95 (95% CI<\/jats:styled-content>, 0.93\u20130.98); P<\/jats:italic> < 0.05 for percentage unit change in o\/e) and liver position (OR<\/jats:styled-content>, 2.82 (95% CI<\/jats:styled-content>, 1.13\u20137.00); P<\/jats:italic> < 0.05 for intrathoracic liver) were significant predictors of subsequent PAH<\/jats:styled-content>. No differences were found after adjusting for gestational age at delivery. The areas under the receiver\u2013operating characteristics curve were 0.80 and 0.75 for o\/e\u2010TFLV<\/jats:styled-content> and o\/e\u2010LHR<\/jats:styled-content>, respectively.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>In cases of CDH<\/jats:styled-content>, PAH<\/jats:styled-content> is associated with high rates of mortality and morbidity. Routinely obtained prenatal markers, usually used for the assessment of pulmonary hypoplasia, are also relevant for the postnatal prediction of PAH<\/jats:styled-content>. Copyright \u00a9 2014 ISUOG. Published by John Wiley & Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.13450","type":"journal-article","created":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T11:58:55Z","timestamp":1403870335000},"page":"572-577","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Prenatal prediction of pulmonary arterial hypertension in congenital diaphragmatic hernia"],"prefix":"10.1002","volume":"45","author":[{"given":"E.","family":"Spaggiari","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Maternal\u2010Fetal Medicine Necker\u2010Enfants Malades Hospital, AP\u2010HP Paris France"},{"name":"University Paris Descartes Sorbonne Paris\u2010Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. J.","family":"Stirnemann","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Maternal\u2010Fetal Medicine Necker\u2010Enfants Malades Hospital, AP\u2010HP Paris France"},{"name":"University Paris Descartes Sorbonne Paris\u2010Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Sonigo","sequence":"additional","affiliation":[{"name":"Department of Radiology Necker\u2010Enfants Malades Hospital, AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Khen\u2010Dunlop","sequence":"additional","affiliation":[{"name":"University Paris Descartes Sorbonne Paris\u2010Cit\u00e9 Paris France"},{"name":"Department of Pediatric Surgery Necker\u2010Enfants Malades Hospital, AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"De Saint Blanquat","sequence":"additional","affiliation":[{"name":"Department of Neonatal Intensive Care 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