{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:20:00Z","timestamp":1773922800853,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,11]],"date-time":"2015-02-11T00:00:00Z","timestamp":1423612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title><jats:styled-content style=\"fixed-case\">ABSTRACT<\/jats:styled-content><\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate perception of pain during Fallopian\u2010tube patency testing by hysterosalpingo\u2010foam sonography (<jats:styled-content style=\"fixed-case\">HyFoSy<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this cross\u2010sectional study, 216 consecutive women presenting at a university fertility clinic for <jats:styled-content style=\"fixed-case\">HyFoSy<\/jats:styled-content> examination were included. Patients were instructed to take ibuprofen 1\u2009hour before the procedure. Immediately after the procedure, patients filled in a questionnaire concerning discomfort or pain experienced during the process, including a visual analog scale (<jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>) score for perception of pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> score for perception of pain during transvaginal ultrasound examination and during <jats:styled-content style=\"fixed-case\">HyFoSy<\/jats:styled-content> examination was 1.5 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.2\u20131.7) and 3.6 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 3.0\u20134.0), respectively. One\u2010third of women reported that the level of discomfort or pain during <jats:styled-content style=\"fixed-case\">HyFoSy<\/jats:styled-content> examination was similar to that during the preceding transvaginal ultrasound examination and 48% of women considered <jats:styled-content style=\"fixed-case\">HyFoSy<\/jats:styled-content> examination to be neutral\/unpleasant, but not painful. There was an inverse association between both patients' age and parity and the pain experienced.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HyFoSy<\/jats:styled-content> examination is tolerated well and allows for reliable tubal patency testing without exposing the patient to ionizing radiation in an outpatient setting with a low technical failure rate. Copyright \u00a9 2014 ISUOG. 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