{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T02:53:20Z","timestamp":1774493600599,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,7,2]],"date-time":"2015-07-02T00:00:00Z","timestamp":1435795200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2015,7]]},"abstract":"ABSTRACT<\/jats:title>Objective<\/jats:title>To assess the accuracy and determine the optimal threshold of sonographic cervical length (CL<\/jats:styled-content>) for the prediction of preterm delivery (PTD<\/jats:styled-content>) in women with twin pregnancies presenting with threatened preterm labor (PTL<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>This was a retrospective study of women with twin pregnancies who presented with threatened PTL<\/jats:styled-content> and underwent sonographic measurement of CL<\/jats:styled-content> in a tertiary center. The accuracy of CL<\/jats:styled-content> in predicting PTD<\/jats:styled-content> in women with twin pregnancies was compared with that in a control group of women with singleton pregnancies.<\/jats:p><\/jats:sec>Results<\/jats:title>Overall, 218 women with a twin pregnancy and 1077 women with a singleton pregnancy, who presented with PTL<\/jats:styled-content>, were included in the study. The performance of CL<\/jats:styled-content> as a predictive test for PTD<\/jats:styled-content> was similar in twins and singletons, as reflected by the similar correlation between CL<\/jats:styled-content> and the examination\u2010to\u2010delivery interval (r,<\/jats:italic> 0.30 vs<\/jats:italic> 0.29; P<\/jats:italic>\u2009=\u20090.9), the similar association of CL<\/jats:styled-content> with risk of PTD<\/jats:styled-content>, and the similar areas under the receiver\u2013operating characteristics curves for differing delivery outcomes (range, 0.653\u20130.724 vs<\/jats:italic> 0.620\u20130.682, respectively; P<\/jats:italic>\u2009=\u20090.3). The optimal threshold of CL<\/jats:styled-content> for any given target sensitivity or specificity was lower in twin than in singleton pregnancies. However, in order to achieve a negative predictive value of 95%, a higher threshold (28\u201330\u2009mm) should be used in twin pregnancies. Using this twin\u2010specific CL<\/jats:styled-content> threshold, women with twins who present with PTL<\/jats:styled-content> are more likely to have a positive CL<\/jats:styled-content> test, and therefore to require subsequent interventions, than are women with singleton pregnancies with PTL<\/jats:styled-content> (55% vs<\/jats:italic> 4.2%, respectively).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>In women with PTL<\/jats:styled-content>, the performance of CL<\/jats:styled-content> as a test for the prediction of PTD<\/jats:styled-content> is similar in twin and singleton pregnancies. However, the optimal threshold of CL<\/jats:styled-content> for the prediction of PTD<\/jats:styled-content> appears to be higher in twin pregnancies, mainly owing to the higher baseline risk for PTD<\/jats:styled-content> in these pregnancies. Copyright \u00a9 2014 ISUOG. Published by John Wiley & Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.14665","type":"journal-article","created":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T06:45:12Z","timestamp":1411454712000},"page":"73-81","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Predictive value of cervical length in women with twin pregnancy presenting with threatened preterm labor"],"prefix":"10.1002","volume":"46","author":[{"given":"N.","family":"Melamed","sequence":"first","affiliation":[{"name":"Helen Schneider Hospital for Women, Rabin Medical Center Petach Tikva Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Hiersch","sequence":"additional","affiliation":[{"name":"Helen Schneider Hospital for Women, Rabin Medical Center Petach Tikva Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University 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