{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T02:55:19Z","timestamp":1778122519825,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,11,28]],"date-time":"2014-11-28T00:00:00Z","timestamp":1417132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ariosa Diagnostics"},{"DOI":"10.13039\/501100003123","name":"Fetal Medicine Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003123","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate whether, in pregnancies complicated by spontaneous preterm delivery, fetal fraction of cell\u2010free <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> (cf<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>) in maternal plasma at 11\u201313 weeks' gestation is altered and if this measurement could be useful in the prediction of preterm delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fetal fraction of cf<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> was measured at 10\u2009+\u20090 to 13\u2009+\u20096\u2009weeks' gestation in 3169 pregnancies, 3066 (96.7%) that delivered at \u2265\u200937\u2009weeks and 103 (3.3%) with spontaneous delivery at\u2009&lt;\u200937\u2009weeks, including 21 that delivered at &lt;\u200934\u2009weeks and 82 that delivered at 34\u201337 weeks. The measured fetal fraction was converted to multiples of the median (<jats:styled-content style=\"fixed-case\">MoM<\/jats:styled-content>), corrected for maternal characteristics and gestational age, and the Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010test was used to determine the significance of differences in the median values in the spontaneous preterm delivery groups from that in the term delivery group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the spontaneous preterm delivery groups (&lt;\u200934\u2009weeks' gestation, 34\u201337 weeks, &lt;\u200937\u2009weeks), compared to the term delivery group, there was no significant difference in the median fetal fraction <jats:styled-content style=\"fixed-case\">MoM<\/jats:styled-content> (1.004, 0.922 and 0.946, respectively, <jats:italic>vs<\/jats:italic> 1.015).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Measurement of fetal fraction in maternal plasma at 11\u201313 weeks' gestation is not predictive of spontaneous preterm delivery. Copyright \u00a9 2014 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.14666","type":"journal-article","created":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T06:30:02Z","timestamp":1411453802000},"page":"101-105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Fetal fraction of cell\u2010free <scp>DNA<\/scp> in maternal plasma in the prediction of spontaneous preterm delivery"],"prefix":"10.1002","volume":"45","author":[{"given":"M. S.","family":"Quezada","sequence":"first","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Francisco","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Dumitrascu\u2010Biris","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. H.","family":"Nicolaides","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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