{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T07:58:57Z","timestamp":1787990337023,"version":"build-2784847793"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T00:00:00Z","timestamp":1422403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32-HL757229"],"award-info":[{"award-number":["T32-HL757229"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2015,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n \n To better understand the natural history and spectrum of fetal aortic stenosis (\n AS<\/jats:styled-content>\n ), we aimed to (1) determine the prenatal diagnosis rate of neonates with critical\n AS<\/jats:styled-content>\n and a biventricular (\n BV<\/jats:styled-content>\n ) outcome, and (2) describe the findings at fetal echocardiography in patients diagnosed prenatally.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A multicenter, retrospective study was performed on neonates who presented with critical\n AS<\/jats:styled-content>\n and who were discharged with a\n BV<\/jats:styled-content>\n outcome from 2000 to 2013. The prenatal diagnosis rate was compared with that reported for hypoplastic left heart syndrome (\n HLHS<\/jats:styled-content>\n ). We reviewed fetal echocardiographic findings in patients who were diagnosed prenatally.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In only 10 (8.5%) of 117 neonates with critical\n AS<\/jats:styled-content>\n and a\n BV<\/jats:styled-content>\n outcome was the diagnosis made prenatally, a rate significantly lower than that for\n HLHS<\/jats:styled-content>\n in the contemporary era (82%;\n P<\/jats:italic>\n \u2009<\u20090.0001). Of the 10 patients diagnosed prenatally, all had developed left ventricular dysfunction by a median gestational age of 33\u2009(range, 28\u201335) weeks. When present, Doppler abnormalities such as retrograde flow in the aortic arch (\n n<\/jats:italic>\n \u2009=\u20092), monophasic mitral inflow (\n n<\/jats:italic>\n \u2009=\u20093) and left\u2010to\u2010right flow across the foramen ovale (\n n<\/jats:italic>\n \u2009=\u20098) developed late in gestation (median 33 weeks).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The prenatal diagnosis rate of critical\n AS<\/jats:styled-content>\n and a\n BV<\/jats:styled-content>\n outcome among neonates is very low, probably owing to a relatively normal four\u2010chamber view in mid\u2010gestation with development of significant obstruction in the third trimester. The natural history contrasts with that of severe mid\u2010gestation\n AS<\/jats:styled-content>\n with evolving\n HLHS<\/jats:styled-content>\n and suggests that the gestational timing of development of significant\n AS<\/jats:styled-content>\n has an important impact on subsequent left\u2010heart growth\n in utero<\/jats:italic>\n . Copyright \u00a9 2014 ISUOG. Published by John Wiley & Sons Ltd.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/uog.14667","type":"journal-article","created":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T02:31:59Z","timestamp":1411439519000},"page":"326-332","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Low rate of prenatal diagnosis among neonates with critical aortic stenosis: insight into the natural history\n in utero<\/i>"],"prefix":"10.1002","volume":"45","author":[{"given":"L. R.","family":"Freud","sequence":"first","affiliation":[{"name":"Department of Cardiology Boston Children's Hospital, Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Moon\u2010Grady","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology Benioff Children's Hospital, University of California\u2010San Francisco School of Medicine San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. C.","family":"Escobar\u2010Diaz","sequence":"additional","affiliation":[{"name":"Department of Cardiology Boston Children's Hospital, Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. L.","family":"Gotteiner","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. T.","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. B.","family":"McElhinney","sequence":"additional","affiliation":[{"name":"Department of Cardiology Boston Children's Hospital, Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Tworetzky","sequence":"additional","affiliation":[{"name":"Department of Cardiology Boston Children's Hospital, Harvard Medical School Boston MA 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