{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:10:38Z","timestamp":1790482238287,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Hunan Province Science & Technology program","award":["2012FJ4142,2013SK3035"],"award-info":[{"award-number":["2012FJ4142,2013SK3035"]}]},{"name":"National Clinical Key Subject (Medical Imageology) Construction Project of China","award":["2013(544)"],"award-info":[{"award-number":["2013(544)"]}]},{"name":"the State Natural Sciences Foundation of China","award":["81271593"],"award-info":[{"award-number":["81271593"]}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title><jats:styled-content style=\"fixed-case\">ABSTRACT<\/jats:styled-content><\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the volume of intracranial structures in fetuses with congenital heart disease (<jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Total intracranial volume, frontal lobes volume, thalamus volume and cerebellar volume were prospectively evaluated and compared in 73 fetuses with <jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content> and 168 normal fetuses using three\u2010dimensional ultrasound combined with post\u2010processing software at 20\u2009+\u20090 to 36\u2009+\u20096 weeks of gestation. Multiple regression analyses were performed to identify risk factors for reduced volume of intracranial structures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From the 28<jats:sup>th<\/jats:sup> week of gestation onwards, total brain volumes and those of specific structures became progressively smaller in fetuses with <jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content> relative to those in controls (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The decrease was largest in frontal lobes volume, followed by total intracranial volume and cerebellar volume, and the smallest decrease was in thalamus volume (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Multivariable analysis showed that the diagnostic category (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) was independently associated with smaller brain volumes in fetuses with <jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content>. The largest differences from controls occurred in hypoplastic left heart syndrome (<jats:styled-content style=\"fixed-case\">HLHS<\/jats:styled-content>), followed by aortic hypoplasia, transposition of the great arteries (<jats:styled-content style=\"fixed-case\">TGA<\/jats:styled-content>) and tetralogy of Fallot (<jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The volume of intracranial structures is smaller in fetuses with  <jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content>, particularly in those with <jats:styled-content style=\"fixed-case\">HLHS<\/jats:styled-content>, aortic hypoplasia or <jats:styled-content style=\"fixed-case\">TGA<\/jats:styled-content>. This study highlights the need for routine brain screening and early intervention to improve neurodevelopmental outcomes in fetuses with <jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content>. Copyright \u00a9 2014 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.14677","type":"journal-article","created":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T09:24:10Z","timestamp":1412155450000},"page":"174-181","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Volume of intracranial structures on three\u2010dimensional ultrasound in fetuses with congenital heart disease"],"prefix":"10.1002","volume":"46","author":[{"given":"S.","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Ultrasonography, Second Xiangya Hospital Central South University  Changsha Hunan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q. 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