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Additionally, we describe the related pathophysiology and staging criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven studies examining methods of predicting <jats:styled-content style=\"fixed-case\">OHSS<\/jats:styled-content> and eight more examining methods of predicting high ovarian response to controlled ovarian stimulation were included. Current evidence shows that the best methods of predicting high response are antral follicle count and anti\u2010M\u00fcllerian hormone levels, and that a high ovarian response (examined by the number of large follicles, estradiol concentration or the number of retrieved oocytes) is the best method of predicting the occurrence of <jats:styled-content style=\"fixed-case\">OHSS<\/jats:styled-content>. Ninety\u2010seven randomized controlled trials examining the effect of several interventions for reducing the occurrence of <jats:styled-content style=\"fixed-case\">OHSS<\/jats:styled-content> were included. There was high\u2010quality evidence that replacing human chorionic gonadotropin by gonadotropin\u2010releasing hormone agonists or recombinant luteinizing hormone, and moderate\u2010quality evidence that antagonist protocols, dopamine agonists and mild stimulation, reduce the occurrence of <jats:styled-content style=\"fixed-case\">OHSS<\/jats:styled-content>. The evidence for the effect of the other interventions was of low\/very low quality. Additionally, we identified and described 12 different staging criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There are useful predictive tools and several preventive interventions aimed at reducing the occurrence of <jats:styled-content style=\"fixed-case\">OHSS<\/jats:styled-content>. Acknowledging and understanding them are of crucial importance for planning the treatment of, and, ultimately, eliminating, <jats:styled-content style=\"fixed-case\">OHSS<\/jats:styled-content> while maintaining high pregnancy rates. Copyright \u00a9 2014 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.14684","type":"journal-article","created":{"date-parts":[[2014,10,9]],"date-time":"2014-10-09T12:54:01Z","timestamp":1412859241000},"page":"377-393","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":162,"title":["Ovarian hyperstimulation syndrome: pathophysiology, staging, prediction and prevention"],"prefix":"10.1002","volume":"45","author":[{"given":"C. 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