{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:58:43Z","timestamp":1791424723177,"version":"4.3.3"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T00:00:00Z","timestamp":1437955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess using fetal magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) the relationship between the position of the stomach as well as the volume of herniation of organs into the thorax, and the observed\u2010to\u2010expected total fetal lung volume (o\/e\u2010<jats:styled-content style=\"fixed-case\">TFLV<\/jats:styled-content>), as a measure of pulmonary hypoplasia, in fetuses with isolated left\u2010sided congenital diaphragmatic hernia (<jats:styled-content style=\"fixed-case\">LCDH<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a single\u2010center retrospective study using archived <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> images from fetuses &gt;\u200920\u2009weeks' gestation evaluated for isolated <jats:styled-content style=\"fixed-case\">LCDH<\/jats:styled-content> over an 11\u2010year period between July 2002 and September 2013. We retrieved data on the gestational age at <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>, o\/e\u2010<jats:styled-content style=\"fixed-case\">TFLV<\/jats:styled-content> and liver position. Images were also reviewed by a single operator to determine retrospectively the position of the stomach as well as the proportion of the total thorax volume occupied by the herniated fetal liver, stomach and other viscera. Following confirmation of reproducibility, we assessed the correlation of intrathoracic organ volumes and stomach position with o\/e\u2010<jats:styled-content style=\"fixed-case\">TFLV<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 205 fetuses which underwent a total of 259 <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> examinations. The reproducibility of organ volume measurements was excellent (intraclass correlation coefficient range, 0.928\u20130.997). The average time spent to obtain intrathoracic organ volumes ranged from 2.28 to 5.13\u2009min. Of all herniated organ\u2010to\u2010thoracic volume ratios, the liver\u2010to\u2010thoracic volume ratio had the strongest correlation with o\/e\u2010<jats:styled-content style=\"fixed-case\">TFLV<\/jats:styled-content> (<jats:italic>\u03c1<\/jats:italic> = \u22120.429, <jats:italic>P<\/jats:italic>&lt;0.0001). Stomach volume did not correlate, although, when categorized by the position and extent of stomach herniation, there was an inverse relationship to o\/e\u2010<jats:styled-content style=\"fixed-case\">TFLV<\/jats:styled-content>. No intrathoracic organ\u2010to\u2010thoracic volume ratio was related to gestational age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We observed in fetuses with isolated <jats:styled-content style=\"fixed-case\">LCDH<\/jats:styled-content> an inverse relationship between lung volume and the amount of liver herniated as well as the position of the stomach in the chest. Copyright \u00a9 2014 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.14701","type":"journal-article","created":{"date-parts":[[2014,10,21]],"date-time":"2014-10-21T08:37:58Z","timestamp":1413880678000},"page":"162-167","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Correlation of observed\u2010to\u2010expected total fetal lung volume with intrathoracic organ herniation on magnetic resonance imaging in fetuses with isolated left\u2010sided congenital diaphragmatic hernia"],"prefix":"10.1002","volume":"46","author":[{"given":"K.","family":"Nawapun","sequence":"first","affiliation":[{"name":"Cluster Organ Systems, Department of Development and Regeneration, Faculty of Medicine Katholieke Universiteit Leuven  Leuven Belgium"},{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynaecology Siriraj Hospital, Faculty of Medicine Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Eastwood","sequence":"additional","affiliation":[{"name":"Cluster Organ Systems, Department of Development and Regeneration, Faculty of Medicine Katholieke Universiteit Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Sandaite","sequence":"additional","affiliation":[{"name":"Cluster Organ Systems, Department of Development and Regeneration, Faculty of Medicine Katholieke Universiteit Leuven  Leuven Belgium"},{"name":"Division of Medical Imaging, Department of Radiology University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"DeKoninck","sequence":"additional","affiliation":[{"name":"Cluster Organ Systems, Department of Development and Regeneration, Faculty of Medicine Katholieke Universiteit Leuven  Leuven Belgium"},{"name":"Fetal Medicine Unit, Department of Obstetrics and Gynaecology University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Claus","sequence":"additional","affiliation":[{"name":"Division of Medical Imaging, Department of Radiology University Hospitals Leuven  Leuven Belgium"},{"name":"Department of Radiology Onze Lieve Vrouw Hospital Aalst  Aalst Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Richter","sequence":"additional","affiliation":[{"name":"Cluster Organ Systems, Department of Development and Regeneration, Faculty of Medicine Katholieke Universiteit Leuven  Leuven Belgium"},{"name":"Fetal Medicine Unit, Department of Obstetrics and Gynaecology University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Rayyan","sequence":"additional","affiliation":[{"name":"Department of Neonatology University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Deprest","sequence":"additional","affiliation":[{"name":"Cluster Organ Systems, Department of Development and Regeneration, Faculty of Medicine Katholieke Universiteit Leuven  Leuven Belgium"},{"name":"Fetal Medicine Unit, Department of Obstetrics and Gynaecology University Hospitals Leuven  Leuven 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