{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T11:37:16Z","timestamp":1775734636636,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,1,27]],"date-time":"2015-01-27T00:00:00Z","timestamp":1422316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2015,3]]},"abstract":"ABSTRACT<\/jats:styled-content><\/jats:title>Objective<\/jats:title>To assess the clinical value of third\u2010trimester uterine artery (UtA<\/jats:styled-content>) Doppler ultrasound in the prediction of hemodynamic deterioration and adverse perinatal outcome in term small\u2010for\u2010gestational\u2010age (SGA<\/jats:styled-content>) fetuses.<\/jats:p><\/jats:sec>Methods<\/jats:title>UtA<\/jats:styled-content> Doppler parameters, cerebroplacental ratio (CPR<\/jats:styled-content>) and fetal middle cerebral artery (MCA<\/jats:styled-content>) pulsatility index (PI<\/jats:styled-content>) were evaluated weekly, starting from the time of SGA<\/jats:styled-content> diagnosis until 24\u2009h before induction of labor, in a cohort of 327 SGA<\/jats:styled-content> fetuses with normal umbilical artery PI<\/jats:styled-content> (<\u200995th<\/jats:sup> centile), delivered at >\u200937\u2009weeks' gestation. Differences in the sequence of CPR<\/jats:styled-content> and MCA\u2010PI<\/jats:styled-content> changes <\u20095th<\/jats:sup> centile, between the group with normal UtA<\/jats:styled-content> Doppler indices at diagnosis and those with abnormal UtA<\/jats:styled-content> indices, were analyzed by survival analysis. In addition, the use of UtA<\/jats:styled-content> Doppler value, alone or in combination with a brain Doppler scan before delivery, to predict the risk of Cesarean section, Cesarean section for non\u2010reassuring fetal status (NRFS<\/jats:styled-content>), neonatal acidosis and neonatal hospitalization was evaluated by logistic regression analysis, adjusted for gestational age at birth and birth\u2010weight percentile.<\/jats:p><\/jats:sec>Results<\/jats:title>Abnormal UtA<\/jats:styled-content> Doppler at diagnosis of SGA<\/jats:styled-content> was associated with a higher risk of developing abnormal brain Doppler indices before induction of labor than in those with a normal UtA<\/jats:styled-content> at diagnosis (62.7% vs<\/jats:italic> 34.6%, respectively; P<\/jats:italic>\u2009<\u20090.01). Compared to those with normal UtA<\/jats:styled-content> Doppler indices, those with abnormal UtA<\/jats:styled-content> Doppler findings were associated with a higher risk of intrapartum Cesarean section (52.2% vs<\/jats:italic> 37.3%, respectively; P<\/jats:italic>\u2009=\u20090.03), Cesarean section for NRFS<\/jats:styled-content> (35.8% vs<\/jats:italic> 23.1%, respectively; P<\/jats:italic>\u2009=\u20090.03), neonatal acidosis (10.4% vs<\/jats:italic> 7.7%, respectively; P<\/jats:italic>\u2009=\u20090.47) and neonatal hospitalization (23.9% vs<\/jats:italic> 16.5%, respectively; P<\/jats:italic>\u2009=\u20090.16). Logistic regression analysis indicated that UtA<\/jats:styled-content> Doppler findings were not significantly associated with adverse perinatal outcome independent of brain Doppler findings.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>UtA<\/jats:styled-content> Doppler indices predict adverse perinatal outcome, but do not help to improve the predictive value of brain Doppler indices. However, at the time of SGA<\/jats:styled-content> diagnosis they identify the subgroup of fetuses at highest risk of progression to abnormal brain Doppler findings. Copyright \u00a9 2014 ISUOG. Published by John Wiley & Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.14706","type":"journal-article","created":{"date-parts":[[2014,10,27]],"date-time":"2014-10-27T07:05:40Z","timestamp":1414393540000},"page":"273-278","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Clinical utility of third\u2010trimester uterine artery Doppler in the prediction of brain hemodynamic deterioration and adverse perinatal outcome in small\u2010for\u2010gestational\u2010age fetuses"],"prefix":"10.1002","volume":"45","author":[{"given":"R.","family":"Cruz\u2010Martinez","sequence":"first","affiliation":[{"name":"Department of Maternal\u2013Fetal Medicine, Institute Cl\u00ednic of Gynecology, Obstetrics and Neonatology (ICGON), Hospital Clinic\u2010IDIBAPS University of Barcelona and Centre for Biomedical Research on Rare Diseases (CIBER\u2010ER) Barcelona Spain"},{"name":"Department of Fetal Medicine and Surgery Children's and Women's Specialty Hospital of Queretaro Quer\u00e9taro Mexico"},{"name":"Unidad de Investigaci\u00f3n en Neurodesarrollo \u2018Dr Augusto Fern\u00e1ndez Guardiola\u2019, Instituto de Neurobiolog\u00eda Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM) Campus Juriquilla Quer\u00e9taro M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Savchev","sequence":"additional","affiliation":[{"name":"Department of Maternal\u2013Fetal Medicine, Institute Cl\u00ednic of Gynecology, Obstetrics and Neonatology (ICGON), Hospital Clinic\u2010IDIBAPS University of Barcelona and Centre for Biomedical Research on Rare Diseases (CIBER\u2010ER) Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Cruz\u2010Lemini","sequence":"additional","affiliation":[{"name":"Department of Maternal\u2013Fetal Medicine, Institute Cl\u00ednic of Gynecology, Obstetrics and Neonatology (ICGON), Hospital Clinic\u2010IDIBAPS University of Barcelona and Centre for Biomedical Research on Rare Diseases (CIBER\u2010ER) Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Mendez","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine and Surgery Children's and Women's Specialty Hospital of Queretaro Quer\u00e9taro Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Gratacos","sequence":"additional","affiliation":[{"name":"Department of Maternal\u2013Fetal Medicine, Institute Cl\u00ednic of Gynecology, Obstetrics and Neonatology (ICGON), Hospital Clinic\u2010IDIBAPS University of Barcelona and Centre for Biomedical Research on Rare Diseases (CIBER\u2010ER) Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Figueras","sequence":"additional","affiliation":[{"name":"Department of Maternal\u2013Fetal Medicine, Institute Cl\u00ednic of Gynecology, Obstetrics and Neonatology (ICGON), Hospital Clinic\u2010IDIBAPS University of Barcelona and Centre for Biomedical Research on Rare Diseases (CIBER\u2010ER) Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.116686"},{"key":"e_1_2_6_3_1","volume-title":"Small\u2010for\u2010Gestational\u2010Age Fetus, Investigation and Management (Green\u2010top Guideline No. 31)","author":"Royal College of Obstetricians and Gynaecologists (RCOG)","year":"2002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)31020-9"},{"key":"e_1_2_6_5_1","first-page":"269","article-title":"Utility of antepartum umbilical artery Doppler velocimetry in intrauterine growth restriction. 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