{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T07:42:13Z","timestamp":1782459733992,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T00:00:00Z","timestamp":1435104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["K12HD001258-13"],"award-info":[{"award-number":["K12HD001258-13"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title><jats:styled-content style=\"fixed-case\">ABSTRACT<\/jats:styled-content><\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the most cost\u2010effective timing of delivery in pregnancies complicated by gastroschisis, using a decision\u2010analytic model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We created a decision\u2010analytic model to compare planned delivery at 35, 36, 37, 38 and 39 weeks' gestation. Outcomes considered were stillbirth, death within 1\u2009year of birth and respiratory distress syndrome (<jats:styled-content style=\"fixed-case\">RDS<\/jats:styled-content>). Probability estimates of events (stillbirth, complex gastroschisis and <jats:styled-content style=\"fixed-case\">RDS<\/jats:styled-content> for each gestational age at delivery and risk of death with simple and complex gastroschisis), utilities and costs assigned to the outcomes were obtained from the published literature. Cost analysis was assessed from a societal perspective, using a willingness\u2010to\u2010pay threshold of $100\u2009000 per surviving infant. Outcomes and costs were considered throughout 1\u2009year of postnatal life. Multiway sensitivity analysis was performed to address uncertainties in baseline assumptions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the base\u2013case analysis, delivery at 38 weeks' gestation was the most cost\u2010effective strategy. Planned delivery at 35 weeks was associated with the fewest stillbirths and deaths within 1 year of delivery, owing largely to a lower ongoing risk of stillbirth. In Monte Carlo simulation when every variable was varied over its entire range, delivery at 38 weeks was cost\u2010effective compared to delivery at 39 weeks in 76% of trials and delivery at 37 weeks was cost\u2010effective in 69% of trials. Delivery at 38 weeks resulted in three additional cases of <jats:styled-content style=\"fixed-case\">RDS<\/jats:styled-content> for every 100 stillbirths or deaths within 1 year that were prevented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>For pregnancies complicated by gastroschisis, the most cost\u2010effective timing of delivery is at 38 weeks. Few additional cases of <jats:styled-content style=\"fixed-case\">RDS<\/jats:styled-content> are caused for every one stillbirth or death within 1 year that was prevented with delivery at 37\u201338 weeks compared with at 39\u2009weeks. Copyright \u00a9 2014 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.14721","type":"journal-article","created":{"date-parts":[[2014,11,6]],"date-time":"2014-11-06T08:16:28Z","timestamp":1415261788000},"page":"227-232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Timing of elective delivery in gastroschisis: a decision and cost\u2010effectiveness analysis"],"prefix":"10.1002","volume":"46","author":[{"given":"L. M.","family":"Harper","sequence":"first","affiliation":[{"name":"The Maternal\u2010Fetal Medicine Division, Department of Obstetrics and Gynecology, Center for Women's Reproductive Health The University of Alabama at Birmingham  Birmingham AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. R.","family":"Goetzinger","sequence":"additional","affiliation":[{"name":"The Maternal\u2010Fetal Medicine Division, Department of Obstetrics and Gynecology Washington University School of Medicine  St Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. R.","family":"Biggio","sequence":"additional","affiliation":[{"name":"The Maternal\u2010Fetal Medicine Division, Department of Obstetrics and Gynecology, Center for Women's Reproductive Health The University of Alabama at Birmingham  Birmingham AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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