{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:09:29Z","timestamp":1785499769988,"version":"3.56.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T00:00:00Z","timestamp":1428883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Vasa previa is an obstetric complication in which the fetal blood vessels lie outside the chorionic plate in close proximity to the internal cervical os. In women with vasa previa, the risk of rupture of these vessels is increased, thus potentially causing fetal death or serious morbidity. Our objective was to assess the accuracy of ultrasound in the prenatal diagnosis of vasa previa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content>, the Cochrane Library and <jats:styled-content style=\"fixed-case\">PubMed<\/jats:styled-content> for studies on vasa previa. Two reviewers independently selected studies on the accuracy of ultrasound in the diagnosis of vasa previa. The studies were scored on methodological quality using the Quality Assessment of Diagnostic Accuracy Studies tool (<jats:styled-content style=\"fixed-case\">QUADAS<\/jats:styled-content>\u20102). Data on sensitivity and specificity were subsequently extracted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The literature search revealed 583 articles, of which two prospective and six retrospective cohort studies were eligible for inclusion in the qualitative analysis. All studies documented methods suitable for the prenatal diagnosis of vasa previa. Four out of the eight studies used transvaginal ultrasound (<jats:styled-content style=\"fixed-case\">TVS<\/jats:styled-content>) for primary evaluation, while the remaining four studies used transabdominal ultrasound and performed a subsequent <jats:styled-content style=\"fixed-case\">TVS<\/jats:styled-content> when vasa previa was suspected. The <jats:styled-content style=\"fixed-case\">QUADAS<\/jats:styled-content>\u20102 tool reflected poor methodology in six of the eight included studies, and prenatal detection rates varied from 53% (10\/19) to 100% (total of 442\u2009633 patients, including 138 cases of vasa previa). In the two prospective studies (<jats:italic>n<\/jats:italic>\u2009=\u200933\u2009795, including 11 cases of vasa previa), transvaginal color Doppler performed during the second trimester detected all cases of vasa previa (sensitivity, 100%) with a specificity of 99.0\u201399.8%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The accuracy of ultrasound in the diagnosis of vasa previa is high when performed transvaginally in combination with color Doppler. Copyright \u00a9 2014 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.14752","type":"journal-article","created":{"date-parts":[[2014,12,10]],"date-time":"2014-12-10T08:23:08Z","timestamp":1418199788000},"page":"516-522","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":109,"title":["Systematic review of accuracy of ultrasound in the diagnosis of vasa previa"],"prefix":"10.1002","volume":"45","author":[{"given":"L.","family":"Ruiter","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology Academic Medical Centre  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Kok","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology Vrije Universiteit Medical Centre  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Limpens","sequence":"additional","affiliation":[{"name":"Medical Library Academic Medical Centre  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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J.","family":"Mol","sequence":"additional","affiliation":[{"name":"The Robinson Research Institute, School of Paediatrics and Reproductive Health University of Adelaide  Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Pajkrt","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology Academic Medical Centre  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1998.12060430.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000123245.48645.98"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2012.712570"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2001.00448.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-007-0142-7"},{"key":"e_1_2_6_7_1","first-page":"561","article-title":"Vasa previa. 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