{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T18:44:32Z","timestamp":1770662672659,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T00:00:00Z","timestamp":1436140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title><jats:styled-content style=\"fixed-case\">ABSTRACT<\/jats:styled-content><\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the performance of screening for small\u2010for\u2010gestational\u2010age (<jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content>) fetuses by ultrasound biometry at 30\u201335 weeks' gestation, and to determine the impact of screening on obstetric and neonatal outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>For this prospective cohort study, pregnant women were recruited from two French university maternity centers between 2003 and 2006. Performance measures of third\u2010trimester biometry for the prediction of <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content>, defined as estimated fetal weight\u2009&lt;\u200910<jats:sup>th<\/jats:sup> centile, were analyzed. Obstetric outcomes and neonatal health status were compared, first, between <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> neonates diagnosed correctly at ultrasound examination (true positive (<jats:styled-content style=\"fixed-case\">TP<\/jats:styled-content>); <jats:italic>n<\/jats:italic>\u2009=\u200945) and <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> neonates that went undiagnosed (false negative (<jats:styled-content style=\"fixed-case\">FN<\/jats:styled-content>); <jats:italic>n<\/jats:italic>\u2009=\u2009110) and, second, between non\u2010<jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> neonates identified as normal at ultrasound examination (true negative (<jats:styled-content style=\"fixed-case\">TN<\/jats:styled-content>); <jats:italic>n<\/jats:italic>\u2009=\u20091641) and non\u2010<jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> neonates diagnosed incorrectly as <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> (false positive (<jats:styled-content style=\"fixed-case\">FP<\/jats:styled-content>); <jats:italic>n<\/jats:italic>\u2009=\u2009101).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the prediction of <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content>, third\u2010trimester ultrasound had a sensitivity of 29.0% (95%\u2009<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 22.5\u201336.6%) and specificity of 94.2% (95%\u2009<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 93.0\u201395.2%). Positive and negative predictive values were 30.8% (95%\u2009<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 23.9\u201338.7%) and 93.7% (95%\u2009<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 92.5\u201394.8%), respectively. One hundred and ten <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> neonates went undiagnosed at ultrasound. Compared to the <jats:styled-content style=\"fixed-case\">TN<\/jats:styled-content> neonates considered as of normal weight at ultrasound, planned preterm delivery (before 37 weeks) and elective Cesarean section for a fetal growth indication were 2.4 (<jats:italic>P<\/jats:italic>\u2009=\u20090.01) and 2.85 (<jats:italic>P<\/jats:italic>\u2009=\u20090.003) times more likely to occur, respectively, in the <jats:styled-content style=\"fixed-case\">FP<\/jats:styled-content> group of non\u2010<jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> neonates, diagnosed incorrectly as <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> during the antenatal period. There was no statistically significant difference in 5\u2010min Apgar score\u2009&lt;\u20097, cord blood <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> at birth\u2009&lt;\u20097.15 and need for neonatal resuscitation between the two subgroups (<jats:styled-content style=\"fixed-case\">TN<\/jats:styled-content> <jats:italic>vs<\/jats:italic> <jats:styled-content style=\"fixed-case\">FP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TP<\/jats:styled-content> <jats:italic>vs<\/jats:italic> <jats:styled-content style=\"fixed-case\">FN<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The performance of third\u2010trimester ultrasound screening for <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> seems poor, as it misses the diagnosis of a large number of <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> neonates. The consequences of routine screening for <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> in a low\u2010risk population may lead to unnecessary planned preterm deliveries and elective Cesarean sections in <jats:styled-content style=\"fixed-case\">FP<\/jats:styled-content> pregnancies, without improved neonatal outcome in the <jats:styled-content style=\"fixed-case\">FN<\/jats:styled-content> pregnancies. Copyright \u00a9 2014 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.14755","type":"journal-article","created":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T17:27:01Z","timestamp":1418146021000},"page":"216-220","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Impact on obstetric outcome of third\u2010trimester screening for small\u2010for\u2010gestational\u2010age fetuses"],"prefix":"10.1002","volume":"46","author":[{"given":"R.","family":"Callec","sequence":"first","affiliation":[{"name":"Obstetrics and Fetal Medicine Unit Centre Hospitalier Universitaire  Nancy France"},{"name":"Universit\u00e9 de Lorraine  Nancy France"},{"name":"INSERM  U947, Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Lamy","sequence":"additional","affiliation":[{"name":"Obstetrics and Fetal Medicine Unit Centre Hospitalier Universitaire  Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Perdriolle\u2010Galet","sequence":"additional","affiliation":[{"name":"Obstetrics and Fetal Medicine Unit Centre Hospitalier Universitaire  Nancy France"},{"name":"Universit\u00e9 de Lorraine  Nancy France"},{"name":"INSERM  U947, Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Patte","sequence":"additional","affiliation":[{"name":"Obstetrics and Fetal Medicine Unit Centre Hospitalier Universitaire  Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Heude","sequence":"additional","affiliation":[{"name":"Centre for Research in Epidemiology and Population Health (CESP) INSERM  Villejuif France"},{"name":"Universit\u00e9 Paris Sud  Villejuif France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Morel","sequence":"additional","affiliation":[{"name":"Obstetrics and Fetal Medicine Unit Centre Hospitalier Universitaire  Nancy France"},{"name":"Universit\u00e9 de Lorraine  Nancy France"},{"name":"INSERM  U947, Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the EDEN Mother\u2013Child Cohort Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,6]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1018","article-title":"Intra\u2010uterine growth retardation: guidelines for clinical practice\u00a0\u2013\u00a0Short text","volume":"42","author":"French College of Gynecologists and Obstetricians","year":"2013","journal-title":"J Gynecol Obstet Biol Reprod (Paris)"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2004.02.009"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904223401603"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2008.01827.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.OGX.0000133943.54530.76"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62233-7"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2008.04.010"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1806"},{"key":"e_1_2_6_10_1","unstructured":"SureauC HenrionR; Comit\u00e9 national technique de l'\u00e9chographie de d\u00e9pistage pr\u00e9natal.Rapport du Comit\u00e9 national technique de l'\u00e9chographie de d\u00e9pistage pr\u00e9natal. 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