{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:58:08Z","timestamp":1786978688343,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T00:00:00Z","timestamp":1446508800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet & Gyne"],"published-print":{"date-parts":[[2015,11]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n \n To assess the performance of middle cerebral artery peak systolic velocity (\n MCA\u2010PSV<\/jats:styled-content>\n ) and of the expected daily decrease in fetal hemoglobin in determining the timing of serial\n in\u2010utero<\/jats:italic>\n transfusions (\n IUT<\/jats:styled-content>\n ) in red\u2010cell alloimmunization.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This was a retrospective study of a continuous series of suspected anemic fetuses undergoing\n IUT<\/jats:styled-content>\n between June 2003 and December 2012. Doppler measurement of\n MCA\u2010PSV<\/jats:styled-content>\n and pre\u2010 and post\u2010transfusion hemoglobin levels were recorded at the time of the first, second and third\n IUT<\/jats:styled-content>\n . Receiver\u2013operating characteristics (\n ROC<\/jats:styled-content>\n ) curves and negative and positive predictive values of\n MCA\u2010PSV<\/jats:styled-content>\n in the prediction of severe fetal anemia were calculated. The daily decrease of fetal hemoglobin (Hb) between\n IUTs<\/jats:styled-content>\n was calculated. Regression analysis was used to assess the correlation between pretransfusion fetal hemoglobin and\n MCA\u2010PSV<\/jats:styled-content>\n , and between observed and expected (by projection of daily decreases) pretransfusion fetal hemoglobin levels.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n One hundred and eleven fetuses required an IUT, of which 96 and 67 received a second and third IUT, respectively. The area under the\n ROC<\/jats:styled-content>\n curve for\n MCA\u2010PSV<\/jats:styled-content>\n in the prediction of severe fetal anemia was not different for each rank of transfusion. The positive predictive value of\n MCA\u2010PSV<\/jats:styled-content>\n decreased from 75.3% at the first\n IUT<\/jats:styled-content>\n , to 46.7% and 48.8% at the second and third\n IUTs<\/jats:styled-content>\n , respectively, while the negative predictive value for a 1.5\u2010\n MoM<\/jats:styled-content>\n threshold remained high (88.9% at the second and 91.7% at the third\n IUT<\/jats:styled-content>\n ). The mean daily decrease in hemoglobin following each transfusion was 0.45, 0.35 and 0.32\u2009g\/\n dL<\/jats:styled-content>\n , respectively. There was a persistent linear correlation between fetal hemoglobin and\n MCA\u2010PSV<\/jats:styled-content>\n and between observed and expected fetal hemoglobin levels.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Both\n MCA\u2010PSV<\/jats:styled-content>\n and projection of daily decrease in hemoglobin are reliable means of diagnosing fetal anemia following previous\n IUTs<\/jats:styled-content>\n . The high negative predictive value of\n MCA\u2010PSV<\/jats:styled-content>\n could allow subsequent\n IUTs<\/jats:styled-content>\n to be postponed in selected cases. Copyright \u00a9 2014 ISUOG. Published by John Wiley & Sons Ltd.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/uog.14772","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T06:40:18Z","timestamp":1418971218000},"page":"600-605","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Determination of optimal timing of serial\n in\u2010utero<\/i>\n transfusions in red\u2010cell alloimmunization"],"prefix":"10.1002","volume":"46","author":[{"given":"S.","family":"Friszer","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, H\u00f4pital Trousseau, Assistance Publique\u00a0\u2013\u00a0H\u00f4pitaux de Paris Universit\u00e9 Pierre et Marie Curie Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Maisonneuve","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, H\u00f4pital Trousseau, Assistance Publique\u00a0\u2013\u00a0H\u00f4pitaux de Paris Universit\u00e9 Pierre et Marie Curie Paris France"},{"name":"Centre National de R\u00e9f\u00e9rence en H\u00e9mobiologie P\u00e9rinatale, H\u00f4pitaux Saint\u2010Antoine et Trousseau, Assistance Publique\u00a0\u2013\u00a0H\u00f4pitaux de Paris Universit\u00e9 Pierre et Marie Curie Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Mac\u00e9","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, H\u00f4pital Trousseau, Assistance Publique\u00a0\u2013\u00a0H\u00f4pitaux de Paris Universit\u00e9 Pierre et Marie Curie Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Castaigne","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, H\u00f4pital Trousseau, Assistance Publique\u00a0\u2013\u00a0H\u00f4pitaux de Paris Universit\u00e9 Pierre et Marie Curie Paris France"},{"name":"Centre National de R\u00e9f\u00e9rence en H\u00e9mobiologie P\u00e9rinatale, H\u00f4pitaux Saint\u2010Antoine et Trousseau, Assistance Publique\u00a0\u2013\u00a0H\u00f4pitaux de Paris Universit\u00e9 Pierre et Marie Curie Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Cortey","sequence":"additional","affiliation":[{"name":"Centre National de R\u00e9f\u00e9rence en H\u00e9mobiologie P\u00e9rinatale, H\u00f4pitaux Saint\u2010Antoine et Trousseau, Assistance Publique\u00a0\u2013\u00a0H\u00f4pitaux de Paris Universit\u00e9 Pierre et Marie Curie Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Mailloux","sequence":"additional","affiliation":[{"name":"Centre National de R\u00e9f\u00e9rence en H\u00e9mobiologie P\u00e9rinatale, H\u00f4pitaux Saint\u2010Antoine et Trousseau, Assistance Publique\u00a0\u2013\u00a0H\u00f4pitaux de Paris Universit\u00e9 Pierre et Marie Curie Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Pernot","sequence":"additional","affiliation":[{"name":"Centre National de R\u00e9f\u00e9rence en H\u00e9mobiologie P\u00e9rinatale, H\u00f4pitaux Saint\u2010Antoine et Trousseau, Assistance Publique\u00a0\u2013\u00a0H\u00f4pitaux de Paris Universit\u00e9 Pierre et Marie Curie Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Carbonne","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, H\u00f4pital Trousseau, Assistance Publique\u00a0\u2013\u00a0H\u00f4pitaux de Paris Universit\u00e9 Pierre et Marie Curie Paris France"},{"name":"Centre National de R\u00e9f\u00e9rence en H\u00e9mobiologie P\u00e9rinatale, H\u00f4pitaux Saint\u2010Antoine et Trousseau, Assistance Publique\u00a0\u2013\u00a0H\u00f4pitaux de Paris Universit\u00e9 Pierre et Marie Curie Paris 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