{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:01:24Z","timestamp":1791262884169,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Vetenskapsr\u00c3\u00a5det","award":["2014-3561"],"award-info":[{"award-number":["2014-3561"]}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To evaluate\n                      <jats:italic>in\u2010vivo<\/jats:italic>\n                      placental perfusion fraction, estimated by magnetic resonance imaging (\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      ), as a marker of placental function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A study population of 35 pregnant women, of whom 13 had pre\u2010eclampsia (\n                      <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content>\n                      ), were examined at 22\u201340\u2009weeks' gestation. Within a 24\u2010h period, each woman underwent an\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      diffusion\u2010weighted sequence (from which we calculated the placental perfusion fraction), venous blood sampling and an ultrasound examination including estimation of fetal weight, amniotic fluid index and Doppler velocity measurements. The perfusion fractions in pregnancies with and without fetal growth restriction were compared and correlations between the perfusion fraction and ultrasound estimates and plasma markers were estimated using linear regression. The associations between the placental perfusion fraction and ultrasound estimates were modified by the presence of\n                      <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009\u2009&lt;\u2009\u20090.05) and therefore we included an interaction term between\n                      <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content>\n                      and covariates in the models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median placental perfusion fractions in pregnancies with and without fetal growth restriction were 21% and 32%, respectively (\n                      <jats:italic>P\u2009<\/jats:italic>\n                      =\u20090.005). The correlations between placental perfusion fraction and ultrasound estimates and plasma markers were highly significant (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002 and\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0001, respectively). The highest coefficient of determination (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.56) for placental perfusion fraction was found for a model that included pulsatility index in the ductus venosus, plasma level of soluble fms\u2010like tyrosine kinase\u20101, estimated fetal weight and presence of PE.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The placental perfusion fraction has the potential to contribute to the clinical assessment of cases with placental insufficiency. \u00a9 2015 Authors. Ultrasound in Obstetrics &amp; Gynecology published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.14786","type":"journal-article","created":{"date-parts":[[2015,1,14]],"date-time":"2015-01-14T05:33:41Z","timestamp":1421213621000},"page":"700-705","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Magnetic resonance imaging\u2010estimated placental perfusion in fetal growth assessment"],"prefix":"10.1002","volume":"46","author":[{"given":"S.","family":"Sohlberg","sequence":"first","affiliation":[{"name":"Department of Women's and Children's Health Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Mulic\u2010Lutvica","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Uppsala University  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