{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:30:04Z","timestamp":1791286204647,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011102","name":"European Union 7th Framework Programme","doi-asserted-by":"crossref","award":["601852"],"award-info":[{"award-number":["601852"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003123","name":"The Fetal Medicine Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003123","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To define the contribution of maternal variables which influence the measured level of maternal serum placental growth factor (<jats:styled-content style=\"fixed-case\">PlGF<\/jats:styled-content>) in screening for pregnancy complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Maternal characteristics and medical history were recorded and serum levels of <jats:styled-content style=\"fixed-case\">PlGF<\/jats:styled-content> were measured in women with a singleton pregnancy attending for three routine hospital visits at 11 + 0 to 13 + 6, 19 + 0 to 24 + 6 and 30 + 0 to 34 + 6 or 35 + 0 to 37 + 6 weeks' gestation. For women delivering phenotypically normal live births or stillbirths \u2265 24 weeks' gestation, variables from maternal demographic characteristics and medical history important in the prediction of <jats:styled-content style=\"fixed-case\">PlGF<\/jats:styled-content> were determined from a linear mixed\u2010effects multiple regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum levels of <jats:styled-content style=\"fixed-case\">PlGF<\/jats:styled-content> were measured in 38 002 cases in the first trimester, 10 281 in the second trimester and 12 392 in the third trimester. Significant independent contributions to serum <jats:styled-content style=\"fixed-case\">PlGF<\/jats:styled-content> were provided by gestational age, maternal age, weight and racial origin, cigarette smoking, diabetes mellitus, and gestational age at delivery and birth\u2010weight <jats:italic>Z<\/jats:italic>\u2010score of the neonate in the previous pregnancy. The machine used to measure serum <jats:styled-content style=\"fixed-case\">PlGF<\/jats:styled-content> was also found to have a significant effect. Allowing for other factors, the effect of maternal age on <jats:styled-content style=\"fixed-case\">PlGF<\/jats:styled-content> changed over the three trimesters, whereas other variables had constant effects over the three trimesters. Random\u2010effects multiple regression analysis was used to define the contribution of maternal variables that influence the measured serum <jats:styled-content style=\"fixed-case\">PlGF<\/jats:styled-content> and express the values as multiples of the median (<jats:styled-content style=\"fixed-case\">MoMs<\/jats:styled-content>). The model was shown to provide an adequate fit of <jats:styled-content style=\"fixed-case\">MoM<\/jats:styled-content> values for all covariates, both in pregnancies that developed pre\u2010eclampsia and in those without this complication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A model was fitted to express the measured level of maternal serum <jats:styled-content style=\"fixed-case\">PlGF<\/jats:styled-content> across the three trimesters of pregnancy as <jats:styled-content style=\"fixed-case\">MoMs<\/jats:styled-content>, after adjusting for variables of maternal characteristics and medical history that affect this measurement. Copyright \u00a9 2015 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.14811","type":"journal-article","created":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T17:28:56Z","timestamp":1423070936000},"page":"591-598","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":147,"title":["Serum placental growth factor in the three trimesters of pregnancy: effects of maternal characteristics and medical history"],"prefix":"10.1002","volume":"45","author":[{"given":"A.","family":"Tsiakkas","sequence":"first","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Duvdevani","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Wright","sequence":"additional","affiliation":[{"name":"Institute of Health Research University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Wright","sequence":"additional","affiliation":[{"name":"Institute of Health Research University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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