{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:05:01Z","timestamp":1787162701858,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008061","name":"Fundacion Mutua Madrile\u00f1a","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008061","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fundaci\u00f3 Agrupaci\u00f3 Mutua"},{"name":"Instituto de Salud Carlos III and Ministerio de Economia y Competitividad","award":["PI11\/00051"],"award-info":[{"award-number":["PI11\/00051"]}]},{"name":"Instituto de Salud Carlos III and Ministerio de Economia y Competitividad","award":["PI11\/01709"],"award-info":[{"award-number":["PI11\/01709"]}]},{"name":"Instituto de Salud Carlos III and Ministerio de Economia y Competitividad","award":["PI12\/00851"],"award-info":[{"award-number":["PI12\/00851"]}]},{"name":"Obra Social \u201cla Caixa\u201d"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2015,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n \n To assess maternal vascular structure and function in pregnancies complicated by fetal growth restriction (\n FGR<\/jats:styled-content>\n ), in women with and without pre\u2010eclampsia (\n PE<\/jats:styled-content>\n ) at the time of\n FGR<\/jats:styled-content>\n diagnosis.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We evaluated 124 women with a pregnancy complicated by\n FGR<\/jats:styled-content>\n , of whom 60 had\n PE<\/jats:styled-content>\n and 64 did not, and compared these findings to those of 110 normal women (controls). The group of\n FGR<\/jats:styled-content>\n pregnancies without\n PE<\/jats:styled-content>\n was further subdivided according to gestational age at\n FGR<\/jats:styled-content>\n diagnosis into early onset (<\u200932\u2009weeks) or late onset (\u2265\u200932\u2009weeks). Maternal carotid intima\u2013media thickness (\n IMT<\/jats:styled-content>\n ), blood pressure (\n BP<\/jats:styled-content>\n ), carotid artery distensibility (\n CD<\/jats:styled-content>\n ), circumferential wall stress (\n CWS<\/jats:styled-content>\n ) and inferior vena cava (\n IVC<\/jats:styled-content>\n ) collapsibility were assessed by ultrasound at the time of\n FGR<\/jats:styled-content>\n diagnosis.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Compared to controls, cases of\n FGR<\/jats:styled-content>\n with\n PE<\/jats:styled-content>\n showed increased maternal carotid\n IMT<\/jats:styled-content>\n (0.425 (interquartile range (\n IQR<\/jats:styled-content>\n ), 0.381\u20130.486)\n vs<\/jats:italic>\n 0.409\u2009(\n IQR<\/jats:styled-content>\n , 0.386\u20130.439) mm;\n P\u2009<\/jats:italic>\n =\u20090.021),\n BP<\/jats:styled-content>\n (mean, 109\u2009(\n IQR<\/jats:styled-content>\n , 101\u2013117)\n vs<\/jats:italic>\n 82\u2009 (\n IQR<\/jats:styled-content>\n , 77\u201389)\n mmHg<\/jats:styled-content>\n ;\n P<\/jats:italic>\n \u2009\u2009<\u20090.001) and\n CWS<\/jats:styled-content>\n (19.7 (IQR, 17.0\u201322.7)\n vs<\/jats:italic>\n 12.2 (IQR, 11.1\u201313.7) kPa;\n P<\/jats:italic>\n \u2009<\u20090.001), and reduced\n CD<\/jats:styled-content>\n (25.3 (IQR, 15.7\u201335.6)\n vs<\/jats:italic>\n 31.9 (IQR, 25.4\u201341.1) kPa\n \u22121<\/jats:sup>\n \u2009\u00d7\u200910\n \u22123<\/jats:sup>\n ;\n P<\/jats:italic>\n \u2009=\u20090.037) and\n IVC<\/jats:styled-content>\n collapsibility indices (0.07 (\n IQR<\/jats:styled-content>\n , 0.06\u20131.11)\n vs<\/jats:italic>\n 0.10 (\n IQR<\/jats:styled-content>\n , 0.06\u20130.13);\n P<\/jats:italic>\n \u2009\u2009=\u2009\u20090.136). Similarly, compared to controls, in cases of\n FGR<\/jats:styled-content>\n without\n PE<\/jats:styled-content>\n maternal carotid\n IMT<\/jats:styled-content>\n (0.436\u2009 (\n IQR<\/jats:styled-content>\n , 0.392\u20130.476) mm;\n P<\/jats:italic>\n \u2009\u2009=\u20090.001) and\n BP<\/jats:styled-content>\n (88 (\n IQR<\/jats:styled-content>\n , 81\u201395)\n mmHg<\/jats:styled-content>\n ;\n P\u2009<\/jats:italic>\n <\u20090.001) were increased but\n CD<\/jats:styled-content>\n and\n IVC<\/jats:styled-content>\n collapsibility were similar. When analysis was subclassified according to gestational age at diagnosis,\n IMT<\/jats:styled-content>\n and\n CWS<\/jats:styled-content>\n were significantly increased only in early\u2010onset\n FGR<\/jats:styled-content>\n while\n BP<\/jats:styled-content>\n was increased in both groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Normotensive women with pregnancy complicated by\n FGR<\/jats:styled-content>\n share some subclinical vascular features with those of women with\n PE<\/jats:styled-content>\n , which further reinforces the notion that, at least in a proportion of cases, there is a common placental disease that influences maternal cardiovascular features. Copyright \u00a9 2015 ISUOG. Published by John Wiley & Sons Ltd.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/uog.14815","type":"journal-article","created":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T22:31:55Z","timestamp":1423780315000},"page":"706-712","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Maternal subclinical vascular changes in fetal growth restriction with and without pre\u2010eclampsia"],"prefix":"10.1002","volume":"46","author":[{"given":"I.","family":"Stergiotou","sequence":"first","affiliation":[{"name":"BCNatal\u2010Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de Deu) Barcelona Spain"},{"name":"IDIBAPS, University of Barcelona and Centre for Biomedical Research on Rare Diseases (CIBER\u2010ER) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Bijnens","sequence":"additional","affiliation":[{"name":"ICREA 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