{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T07:21:31Z","timestamp":1790493691213,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T00:00:00Z","timestamp":1428537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"EC FP7","award":["601852"],"award-info":[{"award-number":["601852"]}]},{"DOI":"10.13039\/501100003123","name":"Fetal Medicine Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003123","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the value of fetal biometry at 35\u201337 weeks' gestation in the prediction of delivery of small\u2010for\u2010gestational\u2010age (<jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content>) neonates, in the absence of pre\u2010eclampsia (<jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a screening study in singleton pregnancies at 35\u201337 weeks' gestation, comprising 278 that delivered <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> neonates with a birth weight &lt; 5<jats:sup>th<\/jats:sup> percentile and 5237 cases unaffected by <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> or gestational hypertension. Multivariable logistic regression analysis was used to determine if screening by a combination of maternal factors and <jats:italic>Z<\/jats:italic>\u2010scores of fetal head circumference (<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>), abdominal circumference (<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>) and femur length (<jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>) or estimated fetal weight (<jats:styled-content style=\"fixed-case\">EFW<\/jats:styled-content>) had a significant contribution to the prediction of <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> neonates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multivariable logistic regression analysis demonstrated that the likelihood of delivering a <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> neonate with a birth weight &lt; 5<jats:sup>th<\/jats:sup> percentile decreased with maternal weight and height, and in parous women the risk increased with a longer interpregnancy interval. The risk was higher in women of Afro\u2010Caribbean and South Asian racial origins, in cigarette smokers, nulliparous women and in those with history of <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content>, with or without prior <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content>. Combined screening by maternal characteristics and history with EFW <jats:italic>Z<\/jats:italic>\u2010scores at 35\u201337 weeks predicted 89% of <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> neonates with birth weight &lt; 5<jats:sup>th<\/jats:sup> percentile delivering &lt; 2 weeks following assessment, at a 10% false\u2010positive rate (<jats:styled-content style=\"fixed-case\">FPR<\/jats:styled-content>). The respective detection rate for the prediction of <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> neonates delivering \u2265 37 weeks' gestation was 70%. The performance of screening by a combination of Z\u2010scores of fetal <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> was similar to that achieved by the EFW <jats:italic>Z<\/jats:italic>\u2010score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Combined testing by maternal characteristics and fetal biometry at 35\u201337 weeks could identify, at a 10% <jats:styled-content style=\"fixed-case\">FPR<\/jats:styled-content>, about 90% of pregnancies that subsequently deliver <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> neonates within 2 weeks of assessment and 70% of those that deliver \u2265 37 weeks. Copyright \u00a9 2015 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.14816","type":"journal-article","created":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T09:02:49Z","timestamp":1425286969000},"page":"559-565","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Prediction of small\u2010for\u2010gestational\u2010age neonates: screening by fetal biometry at 35\u201337 weeks"],"prefix":"10.1002","volume":"45","author":[{"given":"C.","family":"Fadigas","sequence":"first","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Saiid","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. C.","family":"Poon","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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