{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:24:25Z","timestamp":1788870265525,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003123","name":"Fetal Medicine Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003123","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2015,4]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n \n To define the contribution of maternal variables which influence the measured fetal middle cerebral artery (\n MCA<\/jats:styled-content>\n ) and umbilical artery (\n UA<\/jats:styled-content>\n ) pulsatility index (\n PI<\/jats:styled-content>\n ) in the assessment of fetal wellbeing.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Maternal characteristics and medical history were recorded and fetal\n MCA\u2010PI<\/jats:styled-content>\n and\n UA\u2010PI<\/jats:styled-content>\n (\n n<\/jats:italic>\n \u2009=\u200936\u2009818) were measured in women with singleton pregnancies attending a routine hospital visit at 30\u2009+\u20090 to 37\u2009+\u20096\u2009weeks' gestation. For pregnancies delivering phenotypically normal live births or stillbirths \u2265\u200930\u2009weeks' gestation, variables among maternal demographic characteristics and medical history that are important in the prediction of\n MCA\u2010PI<\/jats:styled-content>\n and\n UA\u2010PI<\/jats:styled-content>\n were determined by multiple linear regression analysis.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Significant independent contributions to\n MCA\u2010PI<\/jats:styled-content>\n were provided by gestational age at assessment, East Asian racial origin, being parous and birth\u2010weight\n Z<\/jats:italic>\n \u2010score of the neonate of the previous pregnancy. Significant independent contributions to\n UA\u2010PI<\/jats:styled-content>\n were provided by gestational age at assessment, Afro\u2010Caribbean, East Asian and mixed racial origin, cigarette smoking, being parous and birth\u2010weight\n Z<\/jats:italic>\n \u2010score of the neonate of the previous pregnancy. Multiple linear regression analysis was used to define the contribution of maternal variables that influence the measured\n MCA\u2010PI<\/jats:styled-content>\n and\n UA\u2010PI<\/jats:styled-content>\n and express the values as multiples of the median (\n MoMs<\/jats:styled-content>\n ). The cerebroplacental ratio (\n CPR<\/jats:styled-content>\n )\n MoM<\/jats:styled-content>\n was calculated by dividing\n MCA\u2010PI MoM<\/jats:styled-content>\n by\n UA\u2010PI MoM<\/jats:styled-content>\n . The model was shown to provide an adequate fit of\n MoM<\/jats:styled-content>\n values for all covariates, both in pregnancies that delivered small\u2010for\u2010gestational\u2010age neonates and in those without this pregnancy complication.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n A model was fitted to express\n MCA\u2010PI<\/jats:styled-content>\n ,\n UA\u2010PI<\/jats:styled-content>\n and\n CPR<\/jats:styled-content>\n as\n MoMs<\/jats:styled-content>\n after adjusting for variables from maternal characteristics and medical history that affect this measurement. Copyright \u00a9 2015 ISUOG. Published by John Wiley & Sons Ltd.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/uog.14824","type":"journal-article","created":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T04:43:25Z","timestamp":1424234605000},"page":"402-408","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Fetal middle cerebral artery and umbilical artery pulsatility index: effects of maternal characteristics and medical history"],"prefix":"10.1002","volume":"45","author":[{"given":"R.","family":"Akolekar","sequence":"first","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital London UK"},{"name":"Fetal Medicine Unit Medway Maritime Hospital Gillingham Kent UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Sarno","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Wright","sequence":"additional","affiliation":[{"name":"Institute of Health Research University of Exeter Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Wright","sequence":"additional","affiliation":[{"name":"Institute of Health Research University of Exeter Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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