{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:01:17Z","timestamp":1777417277721,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,6,18]],"date-time":"2015-06-18T00:00:00Z","timestamp":1434585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011102","name":"European Union 7th Framework Programme","doi-asserted-by":"crossref","award":["601852"],"award-info":[{"award-number":["601852"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003123","name":"The Fetal Medicine Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003123","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2015,8]]},"abstract":"ABSTRACT<\/jats:styled-content><\/jats:title>Objective<\/jats:title>To investigate the value of fetal biometry at 19\u201324 weeks' gestation in the prediction of delivery of small\u2010for\u2010gestational\u2010age (SGA<\/jats:styled-content>) neonates, in the absence of pre\u2010eclampsia (PE<\/jats:styled-content>), and examine the potential value of such assessment in deciding whether the third\u2010trimester scan should be at 32 and\/or 36 weeks' gestation.<\/jats:p><\/jats:sec>Methods<\/jats:title>This was a screening study in 88\u2009187 singleton pregnancies, including 5003 (5.7%) that delivered SGA<\/jats:styled-content> neonates with birth weight <\u20095th<\/jats:sup> percentile (SGA<\/jats:styled-content> <\u20095th<\/jats:sup>). Multivariable logistic regression analysis was used to determine if screening by a combination of maternal characteristics and medical history and Z<\/jats:italic>\u2010scores of fetal head circumference (HC<\/jats:styled-content>), abdominal circumference (AC<\/jats:styled-content>) and femur length (FL<\/jats:styled-content>) had significant contribution in predicting SGA<\/jats:styled-content> neonates. A model was developed for selecting the gestational age for third\u2010trimester assessment, at 32 and\/or 36 weeks, based on the results of screening at 19\u201324 weeks.<\/jats:p><\/jats:sec>Results<\/jats:title>Combined screening by maternal factors and fetal biometry at 19\u201324 weeks, predicted 76%, 58% and 44% of SGA<\/jats:styled-content> <\u20095th<\/jats:sup> delivering <\u200932, 32\u201336 and \u2265\u200937\u2009weeks' gestation, respectively, at a false\u2010positive rate (FPR<\/jats:styled-content>) of 10%. The detection rate (DR<\/jats:styled-content>) of SGA<\/jats:styled-content> <\u20095th<\/jats:sup> delivering at 32\u201336 weeks improved from 58% to 82% with screening at 32 weeks rather than at 19\u201324 weeks. Similarly, the DR<\/jats:styled-content> of SGA<\/jats:styled-content> <\u20095th<\/jats:sup> delivering \u2265\u200937\u2009weeks improved from 44% with screening at 19\u201324 weeks to 61% and 76% with screening at 32 and 36 weeks, respectively. In a hypothetical model, it was estimated that if the desired objective of prenatal screening is to predict about 80% of the cases of SGA<\/jats:styled-content> <\u20095th<\/jats:sup>, it would be necessary to select 28% of the population at the 19\u201324\u2010week assessment to be reassessed at 32 weeks and 41% to be reassessed at 36 weeks; in 59% of pregnancies there would be no need for a third\u2010trimester scan.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Prenatal prediction of a high proportion of SGA<\/jats:styled-content> neonates necessitates the undertaking of screening in the third trimester of pregnancy, in addition to assessment in the second trimester, and the timing of such screening, either at 32 and\/or 36 weeks, should be contingent on the results of the assessment at 19\u201324 weeks. Copyright \u00a9 2015 ISUOG. Published by John Wiley & Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.14826","type":"journal-article","created":{"date-parts":[[2015,2,19]],"date-time":"2015-02-19T07:33:10Z","timestamp":1424331190000},"page":"198-207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Prediction of small\u2010for\u2010gestational\u2010age neonates: screening by fetal biometry at 19\u201324 weeks"],"prefix":"10.1002","volume":"46","author":[{"given":"C.","family":"Lesmes","sequence":"first","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. M.","family":"Gallo","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Panaiotova","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. C.","family":"Poon","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. H.","family":"Nicolaides","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1806"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2004.01.037"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1990.tb16237.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1991.10.3.153"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(96)70347-2"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2008.057"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2012.10.010"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10078"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4161"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14771"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14816"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1975.tb00710.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1994.04010034.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000338655"},{"key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1081\/PRG-100104165","article-title":"The classification and diagnosis of the hypertensive disorders of pregnancy: Statement from the international society for the study of hypertension in pregnancy (ISSHP)","volume":"20","author":"Brown MA","year":"2001","journal-title":"Hypertens Pregnancy"},{"key":"e_1_2_6_17_1","unstructured":"Royal College of Obstetricians and Gynaecologists. 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