{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T22:22:26Z","timestamp":1778883746065,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T00:00:00Z","timestamp":1451952000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Nicardipine permits rapid control of blood pressure in women with severe pre\u2010eclampsia (<jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content>) and hypertensive crisis. Our objective was to investigate its maternal and fetal hemodynamic effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten severely pre\u2010eclamptic pregnant women who required intravenous nicardipine for severe hypertension were included in this prospective observational trial. Maternal macrocirculation was assessed by transthoracic echocardiography. Maternal microcirculatory perfusion was examined sublingually with the sidestream dark field imaging technique. Fetal hemodynamics were assessed by Doppler examinations of the uteroplacental and fetal circulations. Maternal cardiac output, total vascular resistance, mitral E\/A ratio and capillary heterogeneity index,  uterine artery pulsatility index and fetal cerebroplacental ratio were considered primary outcomes. Paired measurements, obtained before administration of nicardipine infusion and after stabilization of blood pressure, were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Administration of nicardipine significantly reduced the mean arterial blood pressure (median difference, 26\u2009<jats:styled-content style=\"fixed-case\">mmHg<\/jats:styled-content>; <jats:italic>P<\/jats:italic>\u2009=\u20090.002) and total vascular resistance (median difference, 791 dynes\u2009\u00d7\u2009s\/cm<jats:sup>5<\/jats:sup>; <jats:italic>P<\/jats:italic>\u2009=\u20090.002) in all included women. This induced a reflex tachycardia with consequent increase in cardiac output of 1.55\u2009L\/min (<jats:italic>P<\/jats:italic>\u2009\u2009=\u2009\u20090.004). There were no significant changes in the other determinants of maternal or fetal hemodynamic parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Nicardipine effectively reduces blood pressure through selective afterload reduction that triggers an increase in cardiac output, without affecting maternal diastolic function, or microcirculatory, uteroplacental or fetal perfusion. This hemodynamic response is uniform and predictable. Fetomaternal cardiovascular profiling can be achieved by combining transthoracic echocardiography with obstetric Doppler. Copyright \u00a9 2015 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.14836","type":"journal-article","created":{"date-parts":[[2015,2,26]],"date-time":"2015-02-26T11:18:24Z","timestamp":1424949504000},"page":"89-95","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Hemodynamic effects of intravenous nicardipine in severely pre\u2010eclamptic women with a hypertensive crisis"],"prefix":"10.1002","volume":"47","author":[{"given":"J.","family":"Cornette","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC University Medical Centre  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. A. 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