{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:44:16Z","timestamp":1791229456423,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,6,3]],"date-time":"2015-06-03T00:00:00Z","timestamp":1433289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"European Commission FP7","award":["601852"],"award-info":[{"award-number":["601852"]}]},{"DOI":"10.13039\/501100003123","name":"The Fetal Medicine Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003123","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To define the contribution of maternal variables which influence the measured level of maternal serum pregnancy\u2010associated plasma protein\u2010A (<jats:styled-content style=\"fixed-case\">PAPP<\/jats:styled-content>\u2010A) in screening for pregnancy complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Maternal characteristics and medical history were recorded and serum <jats:styled-content style=\"fixed-case\">PAPP<\/jats:styled-content>\u2010A was measured in women with a singleton pregnancy attending for three routine hospital visits at 11\u2009+\u20090 to 13\u2009+\u20096, 19\u2009+\u20090 to 24\u2009+\u20096 and 30\u2009+\u20090 to 34\u2009+\u20096\u2009weeks' gestation. For pregnancies delivering phenotypically normal live births or stillbirths\u2009\u2265\u200924\u2009weeks' gestation, variables from maternal demographic characteristics and medical history that are important in the prediction of <jats:styled-content style=\"fixed-case\">PAPP<\/jats:styled-content>\u2010A were determined from a linear mixed\u2010effects multiple regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum <jats:styled-content style=\"fixed-case\">PAPP<\/jats:styled-content>\u2010A was measured in 94\u2009966 cases in the first trimester, 7785 in the second trimester and 8286 in the third trimester. Significant independent contributions to serum <jats:styled-content style=\"fixed-case\">PAPP<\/jats:styled-content>\u2010A were provided by gestational age, maternal weight, height, racial origin, cigarette smoking, diabetes mellitus, method of conception, previous pregnancy with or without pre\u2010eclampsia (<jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content>) and birth\u2010weight <jats:italic>Z<\/jats:italic>\u2010score of the neonate in the previous pregnancy. The effects of some variables were similar and those for others differed in the three different trimesters. Random\u2010effects multiple regression analysis was used to define the contribution of maternal variables that influence the measured level of serum <jats:styled-content style=\"fixed-case\">PAPP<\/jats:styled-content>\u2010A and express the values as multiples of the median (<jats:styled-content style=\"fixed-case\">MoMs<\/jats:styled-content>). The model was shown to provide an adequate fit of <jats:styled-content style=\"fixed-case\">MoM<\/jats:styled-content> values for all covariates, both in pregnancies that developed <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> and in those without this pregnancy complication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A model was fitted to express the measured serum <jats:styled-content style=\"fixed-case\">PAPP<\/jats:styled-content>\u2010A across the three trimesters of pregnancy as <jats:styled-content style=\"fixed-case\">MoMs<\/jats:styled-content>, after adjusting for variables from maternal characteristics and medical history that affect this measurement. Copyright \u00a9 2015 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.14870","type":"journal-article","created":{"date-parts":[[2015,4,2]],"date-time":"2015-04-02T22:17:56Z","timestamp":1428013076000},"page":"42-50","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Serum pregnancy\u2010associated plasma protein\u2010A in the three trimesters of pregnancy: effects of maternal characteristics and medical history"],"prefix":"10.1002","volume":"46","author":[{"given":"D.","family":"Wright","sequence":"first","affiliation":[{"name":"Institute of Health Research University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Silva","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Wright","sequence":"additional","affiliation":[{"name":"Institute of Health Research University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. H.","family":"Nicolaides","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5332"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7755"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den224"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2149"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(200005)20:5<390::AID-PD824>3.0.CO;2-B"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2637"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6280"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000321694"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000341712"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000341264"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0412.2004.00277.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1081\/PRG-120016794"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2008.00835.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-011-1912-z"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000338470"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000324320"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2011.03253.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1975.tb00710.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1994.04010034.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1081\/PRG-100104165","article-title":"The classification and diagnosis of the hypertensive disorders of pregnancy: Statement from the international society for the study of hypertension in pregnancy (ISSHP)","volume":"20","author":"Brown MA","year":"2001","journal-title":"Hypertens Pregnancy"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000338655"},{"key":"e_1_2_6_23_1","unstructured":"R Development Core Team R. A language and environment for statistical computing. R Foundation for Statistical Computing Vienna Austria. 2011; ISBN 3\u2010900051\u201007\u20100.http:\/\/www.R\u2010project.org\/."},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.02.018"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.14870","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.14870","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T15:40:18Z","timestamp":1696520418000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.14870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,3]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1002\/uog.14870"],"URL":"https:\/\/doi.org\/10.1002\/uog.14870","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,3]]},"assertion":[{"value":"2015-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-03-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-06-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}