{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T23:23:49Z","timestamp":1785194629745,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T00:00:00Z","timestamp":1451433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify, evaluate and summarize the available evidence regarding the effectiveness and safety of administering a gonadotropin releasing hormone (<jats:styled-content style=\"fixed-case\">GnRH<\/jats:styled-content>) agonist during the luteal phase in women undergoing assisted reproductive techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this systematic review and meta\u2010analysis, we searched for randomized controlled trials (<jats:styled-content style=\"fixed-case\">RCTs<\/jats:styled-content>) comparing the addition of a <jats:styled-content style=\"fixed-case\">GnRH<\/jats:styled-content> agonist during the luteal phase, compared with standard luteal\u2010phase support. We searched seven electronic databases and hand\u2010searched the reference lists of included studies and related reviews. Our primary outcome was live birth or ongoing pregnancy per randomized woman. Our secondary outcomes were clinical pregnancy per randomized woman, miscarriage per clinical pregnancy, adverse perinatal outcome and congenital malformations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The evidence from eight studies examining 2776 women showed a relative risk (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>) for live birth or ongoing pregnancy of 1.26 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.04\u20131.53; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 58%). Sensitivity analysis when excluding the studies that did not report live birth and those at high risk of bias resulted in one study examining 181 women with an RR of 1.07 (95% CI, 0.73\u20131.58). Subgroup analysis separating the studies by single\/multiple doses of GnRH agonists or by ovarian stimulation with GnRH agonist\/antagonist was unable to explain the observed heterogeneity. The quality of the evidence was deemed to be very low: it was downgraded because of the limitation of the included studies, imprecision, inconsistency across the studies' results, and suspicion of publication bias. None of the included studies reported adverse perinatal outcomes or congenital malformations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is evidence that adding GnRH agonist during the luteal phase improves the likelihood of ongoing pregnancy. However, this evidence is of very low quality and there is no evidence for adverse perinatal outcome and congenital malformations. We therefore believe that including this intervention in clinical practice would be premature. Copyright \u00a9 2015 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.14874","type":"journal-article","created":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T06:59:43Z","timestamp":1428562783000},"page":"144-151","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["GnRH agonist during luteal phase in women undergoing assisted reproductive techniques: systematic review and meta\u2010analysis of randomized controlled trials"],"prefix":"10.1002","volume":"47","author":[{"given":"W. P.","family":"Martins","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ribeirao Preto Medical School University of Sao Paulo (DGO\u2010FMRP\u2010USP)  Ribeirao Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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