{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T17:43:46Z","timestamp":1785347026434,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T00:00:00Z","timestamp":1464912000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet & Gyne"],"published-print":{"date-parts":[[2016,6]]},"abstract":"ABSTRACT<\/jats:title>Objective<\/jats:title>To describe the sonographic appearance of fetal posterior fossa anatomy at 11\u201314 weeks of pregnancy and to assess the outcome of fetuses with increased intracranial translucency (IT<\/jats:styled-content>) and\/or brainstem\u2010to\u2010occipital bone (BSOB<\/jats:styled-content>) diameter.<\/jats:p><\/jats:sec>Methods<\/jats:title>Reference ranges for brainstem (BS<\/jats:styled-content>), IT<\/jats:styled-content> and cisterna magna (CM<\/jats:styled-content>) measurements, BSOB<\/jats:styled-content> diameter and the BS<\/jats:styled-content> : BSOB<\/jats:styled-content> ratio were obtained from the first\u2010trimester ultrasound examination of 233 fetuses with normal postnatal outcome (control group). The intraobserver and interobserver variability of measurements were investigated using 73 stored ultrasound images. In addition, a study group of 17 fetuses with increased IT<\/jats:styled-content> and\/or BSOB<\/jats:styled-content> diameter was selected to assess outcome.<\/jats:p><\/jats:sec>Results<\/jats:title>No significant intraobserver or interobserver variability was found for any measurement in the control group. In the study group, IT<\/jats:styled-content> was increased in all cases and BSOB<\/jats:styled-content> diameter was above the 95th<\/jats:sup> centile of the calculated normal range in all but two (88%) cases. In 13\/17 study cases, only two of the three posterior brain spaces were recognized on ultrasound. These 13 fetuses had a larger BSOB<\/jats:styled-content> diameter than did the four cases that showed all three posterior brain spaces, and had severe associated anomalies including Dandy\u2013Walker malformation (DWM<\/jats:styled-content>) and\/or chromosomal anomalies.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Visualization of the fetal posterior fossa anatomy at 11\u201314 weeks' gestation is feasible. Increased fluid in the posterior brain at 11\u201314 weeks, particularly in the case of non\u2010visibility of the septation that divides the future fourth ventricle from the CM<\/jats:styled-content>, is an important risk factor for cystic posterior fossa malformations, in particular DWM<\/jats:styled-content>, and\/or chromosomal aberrations. Copyright \u00a9 2015 ISUOG. Published by John Wiley & Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.14883","type":"journal-article","created":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T10:17:26Z","timestamp":1429784246000},"page":"720-725","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Appearance of fetal posterior fossa at 11\u201314 weeks in fetuses with Dandy\u2013Walker malformation or chromosomal anomalies"],"prefix":"10.1002","volume":"47","author":[{"given":"P.","family":"Volpe","sequence":"first","affiliation":[{"name":"Fetal Medicine Unit, Di Venere and Sarcone Hospitals, ASL BA Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Contro","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Fanelli","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Di Venere and Sarcone Hospitals, ASL BA Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Muto","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Di Venere and Sarcone Hospitals, ASL BA Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Pilu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gentile","sequence":"additional","affiliation":[{"name":"Medical Genetics Unit Di Venere Hospital, ASL BA Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10070"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2637"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2642"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2831"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.3920"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7552"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7329"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10111"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2632"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.9067"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8957"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-003-0792-3"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.3899"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.3868"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.11099"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12302"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.11071"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.11101"}],"container-title":["Ultrasound in Obstetrics & Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.14883","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.14883","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T02:18:25Z","timestamp":1696472305000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.14883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1002\/uog.14883"],"URL":"https:\/\/doi.org\/10.1002\/uog.14883","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"2015-02-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-04-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-06-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}