{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:55:57Z","timestamp":1786978557760,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T00:00:00Z","timestamp":1451952000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet & Gyne"],"published-print":{"date-parts":[[2016,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n \n To compare subjective ultrasound assessment and the\n ADNEX<\/jats:styled-content>\n model with ultrasound\u2010guided tru\u2010cut biopsy to differentiate disseminated primary ovarian cancer from metastatic non\u2010ovarian cancer.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This was a prospective study including 143 consecutive women with disseminated malignancy of unknown primary origin, with a pelvic tumor\/carcinosis. Women underwent either transvaginal or transrectal ultrasound as well as transabdominal ultrasound examination followed by tru\u2010cut biopsy. The ultrasound examiner assessed tumor morphology, spread in the pelvis and abdomen, and predicted tumor origin as primary ovarian or metastatic using both subjective assessment and the\n ADNEX<\/jats:styled-content>\n model. Histology from tru\u2010cut biopsy served as the gold standard for assessment of diagnostic accuracy. Biopsy adequacy and the complication rate were assessed.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Tru\u2010cut biopsy was performed transvaginally in 131\/143 (92%) women. Two women needed inpatient care (one had abdominal wall hematoma, and one infection). Biopsy resulted in a conclusive diagnosis in 126\/143 (88%) women, amongst whom cytoreductive surgery was performed in 30\/126 confirming the diagnosis in all cases. Non\u2010ovarian metastatic cancer was found in 37\/126 (29%) women and primary ovarian cancer in 89\/126 (71%) women. Subjective ultrasound evaluation had a sensitivity of 82% (73\/89) and a specificity of 70% (26\/37) in predicting primary ovarian cancer. The\n ADNEX<\/jats:styled-content>\n model had an area under the receiver\u2013operating characteristics curve of 0.891 (95%\n CI<\/jats:styled-content>\n , 0.794\u20130.946) (in women with an ovarian lesion,\n n<\/jats:italic>\n \u2009=\u2009104). Tumor origin was associated with age,\n CA<\/jats:styled-content>\n \u2009125, previous neoplasia, presence of omental cake and tumor mobility.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Subjective ultrasound assessment and the\n ADNEX<\/jats:styled-content>\n model can both be used to predict whether a pelvic tumor is metastatic and of non\u2010ovarian origin, indicating the need for tru\u2010cut biopsy, which is associated with very few complications and will provide a conclusive diagnosis in nine out of 10 women. Copyright \u00a9 2015 ISUOG. Published by John Wiley & Sons Ltd.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/uog.14892","type":"journal-article","created":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T01:10:26Z","timestamp":1430356226000},"page":"110-116","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Subjective ultrasound assessment, the\n ADNEX<\/scp>\n model and ultrasound\u2010guided tru\u2010cut biopsy to differentiate disseminated primary ovarian cancer from metastatic non\u2010ovarian cancer"],"prefix":"10.1002","volume":"47","author":[{"given":"E.","family":"Epstein","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Van Calster","sequence":"additional","affiliation":[{"name":"KU Leuven Department of Development and Regeneration Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Timmerman","sequence":"additional","affiliation":[{"name":"KU Leuven Department of Development and Regeneration Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Nikman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.4020"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-8258(03)00075-1"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1996.4606"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.55.2.93"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.9030"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g5920"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10100"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2673"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2007.01015.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8803"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10068"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10120"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2000.00287.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-012-9733-3"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1438.2003.13054.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19871001)60:7<1561::AID-CNCR2820600725>3.0.CO;2-V"}],"container-title":["Ultrasound in Obstetrics & Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.14892","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.14892","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.14892","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T13:28:14Z","timestamp":1696339694000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.14892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1002\/uog.14892"],"URL":"https:\/\/doi.org\/10.1002\/uog.14892","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"2015-03-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-04-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-01-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}