{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T02:36:12Z","timestamp":1778553372902,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the potential value of uterine artery (<jats:styled-content style=\"fixed-case\">UtA<\/jats:styled-content>) Doppler at 30\u201334\u2009weeks' gestation in the prediction of adverse perinatal outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a screening study in 30\u2009780 singleton pregnancies at 30\u201334\u2009weeks. <jats:styled-content style=\"fixed-case\">UtA<\/jats:styled-content> pulsatility index (<jats:styled-content style=\"fixed-case\">UtA\u2010PI<\/jats:styled-content>) was measured and the values were converted to multiples of the median (<jats:styled-content style=\"fixed-case\">MoM<\/jats:styled-content>) after adjustment for variables relating to maternal characteristics and medical history that affect the measurements. Multivariable logistic regression analysis was used to determine if measuring <jats:styled-content style=\"fixed-case\">UtA\u2010PI<\/jats:styled-content> improved the prediction of adverse perinatal outcome provided by screening with maternal characteristics, medical history and obstetric factors. The detection rate (<jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>) and false\u2010positive rate (<jats:styled-content style=\"fixed-case\">FPR<\/jats:styled-content>) of screening by <jats:styled-content style=\"fixed-case\">UtA\u2010PI<\/jats:styled-content> were estimated for stillbirth, Cesarean section for fetal distress, umbilical arterial cord blood <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> \u2264\u20097.0 or umbilical venous cord blood <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> \u2264\u20097.1 and 5\u2010min Apgar score\u2009&lt;\u20097.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of adverse perinatal outcome was higher in small\u2010for\u2010gestational\u2010age (<jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content>) fetuses than in non\u2010<jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> fetuses, but the majority of cases with each adverse outcome were in the non\u2010<jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> group, including about 70% of stillbirths and more than 80% with Cesarean section for fetal distress, low cord blood <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> and low Apgar score. The performance of <jats:styled-content style=\"fixed-case\">UtA\u2010PI<\/jats:styled-content> &gt;\u200995<jats:sup>th<\/jats:sup> percentile in screening for each adverse outcome was poor with <jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content> of 6\u201316% and a <jats:styled-content style=\"fixed-case\">FPR<\/jats:styled-content> of 5\u20136%. The <jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content> of adverse outcome when screening by high <jats:styled-content style=\"fixed-case\">UtA\u2010PI<\/jats:styled-content> was greater in pregnancies complicated by <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> than in non\u2010<jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> pregnancies; 24% <jats:italic>vs<\/jats:italic> 13% for stillbirth, 15% <jats:italic>vs<\/jats:italic> 5% for Cesarean section for fetal distress, 30% <jats:italic>vs<\/jats:italic> 9% for low cord blood <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> and 20% <jats:italic>vs<\/jats:italic> 3% for low 5\u2010min Apgar score, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High <jats:styled-content style=\"fixed-case\">UtA\u2010PI<\/jats:styled-content> at 30\u201334\u2009weeks' gestation may be useful in the prediction of adverse perinatal outcome in pregnancies with a <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> fetus, however, in the absence of <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">UtA\u2010PI<\/jats:styled-content> is a poor predictor of adverse outcome. Copyright \u00a9 2015 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.14898","type":"journal-article","created":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T11:56:59Z","timestamp":1431518219000},"page":"308-315","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Uterine artery pulsatility index at 30\u201334 weeks' gestation in the prediction of adverse perinatal outcome"],"prefix":"10.1002","volume":"47","author":[{"given":"N.","family":"Vali\u00f1o","sequence":"first","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Giunta","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. M.","family":"Gallo","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Akolekar","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital  London UK"},{"name":"Department of Fetal Medicine Medway Maritime Hospital  Gillingham Kent UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. 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