{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T15:50:54Z","timestamp":1773071454677,"version":"3.50.1"},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T00:00:00Z","timestamp":1446595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the efficacy of omega\u20103 supplementation during pregnancy in preventing intrauterine growth restriction (<jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>) in women with apparently uncomplicated singleton pregnancy and previous <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content> pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>For this systematic review, the research protocol was designed <jats:italic>a priori<\/jats:italic>. Searches were performed in electronic databases for studies published from inception of each database to December 2014. A combination of search terms was used including \u2018fish oil\u2019, \u2018long chain polyunsaturated fatty acids\u2019, \u2018intrauterine growth restriction\u2019, \u2018small for gestational age\u2019 and \u2018omega\u20103\u2019. We included all randomized controlled trials (<jats:styled-content style=\"fixed-case\">RCTs<\/jats:styled-content>) of women with an uncomplicated singleton pregnancy and a prior <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content> pregnancy who were randomized to receive prophylactic treatment with omega\u20103 supplementation or either placebo or no treatment (control). Trials that included women with multiple gestations and those with only biochemical outcomes available were excluded. Pooled estimates were based on relative risk (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>) with 95%\u2009<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>. Primary outcome was incidence of <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content> as defined in the <jats:styled-content style=\"fixed-case\">RCTs<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three <jats:styled-content style=\"fixed-case\">RCTs<\/jats:styled-content> including 575 women with uncomplicated singleton pregnancy with prior <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content> were analyzed. Women who received omega\u20103 supplementation during pregnancy had the same incidence of <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>, defined as estimated fetal weight\u2009&lt;\u20095<jats:sup>th<\/jats:sup> or\u2009&lt;\u20093<jats:sup>rd<\/jats:sup> centiles, as had controls (22.8% <jats:italic>vs<\/jats:italic> 20.2%, respectively; <jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>, 1.13 (95%\u2009<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.83\u20131.54)). Compared to controls, women who received omega\u20103 supplementation delivered later (mean difference, 1.4 (95%\u2009<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.28\u20131.63) weeks), had a longer latency (mean difference, 2 (95%\u2009<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.73\u20132.08) weeks), had a similar incidence of  perinatal death (2.1% <jats:italic>vs<\/jats:italic> 3.3%, respectively; <jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>, 0.60 (95%\u2009<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.15\u20132.42)) and similar birth weight (mean difference, 50\u2009g (95%\u2009<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, \u221226 to 246\u2009g)).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Omega\u20103 supplementation during pregnancy does not prevent recurrence of <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content> in women with uncomplicated singleton pregnancy and a previous <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content> pregnancy. Copyright \u00a9 2015 ISUOG. 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