{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T10:47:54Z","timestamp":1756810074065},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,3,4]],"date-time":"2016-03-04T00:00:00Z","timestamp":1457049600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the role of transvaginal\/transrectal ultrasound for preoperative identification of high\u2010risk cases among women with well\u2010differentiated (G1) or moderately differentiated (G2) endometrioid carcinoma of the endometrium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a single\u2010center prospective observational cohort study comprising a consecutive series of women with a preoperative diagnosis of G1\/G2 endometrioid carcinoma of the endometrium. All women underwent transvaginal or transrectal ultrasound examination by a single examiner. According to the examiner's subjective impression, patients were considered high risk if myometrial infiltration was \u2265\u200950% and\/or involvement of the cervix and\/or adnexa was suspected. FIGO surgical staging was performed in all cases. According to definitive histological data regarding myometrial infiltration, cervical involvement and adnexal involvement, women were classified as low risk (no myometrial infiltration, no cervical involvement and no adnexal involvement) or high risk (myometrial infiltration \u2265\u200950% and\/or cervical involvement and\/or adnexal involvement). Sensitivity, specificity and positive (LR+) and negative (LR\u2212) likelihood ratios, with 95%\u2009CIs, of transvaginal\/transrectal ultrasound for detecting stage \u2265\u2009IB were calculated. Agreement between risk determined by transvaginal\/transrectal ultrasound and postoperative definitive histology was calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 209 eligible women, 169 were included in the study. Mean\u2009(\u00b1\u2009SD) age of the study cohort was 60.7\u2009\u00b1\u200910.3\u2009years, with a range of 32\u201391\u2009years. Sensitivity, specificity, LR+ and LR\u2212 of transvaginal\/transrectal ultrasound identifying high\u2010risk cases according to myometrial infiltration, cervical involvement and adnexal involvement were 78.0% (95% CI, 63.7\u201388.0%), 89.1% (95%\u2009CI, 81.7\u201393.8%), 7.14 (95%\u2009CI, 4.19\u201312.18) and 0.25 (95%\u2009CI, 0.15\u20130.42), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Preoperative transvaginal\/transrectal ultrasound may play a significant role in identifying high\u2010risk cases among those with G1\/G2 endometrioid carcinoma of the endometrium according to preoperative biopsy, and could be a useful test in this clinical setting. Copyright \u00a9 2015 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.14912","type":"journal-article","created":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T17:21:54Z","timestamp":1432920114000},"page":"374-379","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Transvaginal\/transrectal ultrasound for preoperative identification of high\u2010risk cases in well\u2010 or moderately differentiated endometrioid carcinoma"],"prefix":"10.1002","volume":"47","author":[{"given":"J. L.","family":"Alc\u00e1zar","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Clinica Universidad de Navarra, School of Medicine University of Navarra  Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Pineda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Clinica Universidad de Navarra, School of Medicine University of Navarra  Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Caparr\u00f3s","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Clinica Universidad de Navarra, School of Medicine University of Navarra  Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Utrilla\u2010Layna","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Clinica Universidad de Navarra, School of Medicine University of Navarra  Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Juez","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Clinica Universidad de Navarra, School of Medicine University of Navarra  Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A.","family":"M\u00ednguez","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Clinica Universidad de Navarra, School of Medicine University of Navarra  Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Jurado","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Clinica Universidad de Navarra, School of Medicine University of Navarra  Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,4]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"47","article-title":"Carcinoma of the corpus uteri","volume":"6","author":"Creasman WT","year":"2001","journal-title":"J Epidemiol Biostat"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182605bf1"},{"key":"e_1_2_5_4_1","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD007585.pub2","article-title":"Lymphadenectomy for the management of endometrial cancer","volume":"1","author":"May K","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2013.10.002"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2014.06.022"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-013-0528-7"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12344"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2014.2653"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-014-3139-4"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2011.01.003"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.05.018"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5295"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/IGC.0b013e3181ad3eb6"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.11.025"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0b013e3182185baa"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2282011860"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14909"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001703-199402000-00015"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1995.06050362.x"},{"key":"e_1_2_5_21_1","first-page":"293","article-title":"The value of ultrasonography in preoperative assessment of selected prognostic factors in endometrial cancer","volume":"24","author":"Sawicki W","year":"2003","journal-title":"Eur J Gynaecol Oncol"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12103"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13216"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14645"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.14912","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.14912","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.14912","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T19:22:23Z","timestamp":1696360943000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.14912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1002\/uog.14912"],"URL":"https:\/\/doi.org\/10.1002\/uog.14912","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"2015-01-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-05-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-03-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}