{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:01:21Z","timestamp":1791262881501,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T00:00:00Z","timestamp":1464912000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Speciallaege Heinrich Kopps Legat"},{"name":"Region Nordjyllands Sundhedsvidenskabelige Forskningsfond"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) variable transverse relaxation time (<jats:styled-content style=\"fixed-case\">T2<\/jats:styled-content>*) depends on multiple factors, one important one being the presence of deoxyhemoglobin. We aimed to describe placental <jats:styled-content style=\"fixed-case\">T2<\/jats:styled-content>* measurements in normal pregnancies and in those with fetal growth restriction (<jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 24 normal pregnancies at 24\u201340 weeks' gestation and four <jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content> cases with an estimated fetal weight below the 1<jats:sup>st<\/jats:sup> centile. Prior to <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>, an ultrasound examination, including Doppler flow measurements, was performed. The <jats:styled-content style=\"fixed-case\">T2<\/jats:styled-content>* value was calculated using a gradient echo MRI sequence with readout at 16 different echo times. In normal pregnancies, repeat <jats:styled-content style=\"fixed-case\">T2<\/jats:styled-content>* measurements were performed and interobserver reproducibility was assessed in order to estimate the reproducibility of the method. Placental histological examination was performed in the <jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content> cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The method was robust regarding the technical and interobserver reproducibility. However, some slice\u2010to\u2010slice variation existed owing to the heterogeneous nature of the normal placenta. We therefore based <jats:styled-content style=\"fixed-case\">T2<\/jats:styled-content>* estimations on the average of two slices from each placenta. In normal pregnancies, the placental <jats:styled-content style=\"fixed-case\">T2<\/jats:styled-content>* value decreased significantly with increasing gestational age, with mean \u00b1 <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> values of 120 \u00b1 17 ms at 24 weeks' gestation, 84 \u00b1 16 ms at 32 weeks and 47 \u00b1 17 ms at 40 weeks. Three <jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content> cases had abnormal Doppler flow, histological signs of maternal hypoperfusion and a reduced <jats:styled-content style=\"fixed-case\">T2<\/jats:styled-content>* value (<jats:italic>Z<\/jats:italic>\u2010score &lt; \u20133.5). In the fourth <jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content> case, Doppler flow, placental histology and <jats:styled-content style=\"fixed-case\">T2<\/jats:styled-content>* value (<jats:italic>Z<\/jats:italic>\u2010score, \u22120.34) were normal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The established reference values for placental <jats:styled-content style=\"fixed-case\">T2<\/jats:styled-content>* may be clinically useful, as <jats:styled-content style=\"fixed-case\">T2<\/jats:styled-content>* values were significantly lower in <jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content> cases with histological signs of maternal hypoperfusion. Copyright \u00a9 2015 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.14917","type":"journal-article","created":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T08:25:41Z","timestamp":1433406341000},"page":"748-754","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["Placental magnetic resonance imaging T2* measurements in normal pregnancies and in those complicated by fetal growth restriction"],"prefix":"10.1002","volume":"47","author":[{"given":"M.","family":"Sinding","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. A.","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Clinical Engineering Central Denmark Region  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. B.","family":"Fr\u00f8kj\u00e6r","sequence":"additional","affiliation":[{"name":"Department of Radiology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. B.","family":"Christiansen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Pathology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Uldbjerg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000263922"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm.2010.041"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.295095034"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0730-725X(84)90063-8"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2014.10.003"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4004(97)90000-X"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1996.tb14164.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1137\/0111030"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/096228029900800204"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/15513819609168713"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10024-003-8083-2"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2011.07.008"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1940070104"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24581"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0730-725X(97)00308-1"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000262264"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2014.01.008"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13121742"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1087"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910400318"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4004(98)91048-7"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2013.03.005"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2005.05.001"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.14917","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.14917","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T02:18:33Z","timestamp":1696472313000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.14917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1002\/uog.14917"],"URL":"https:\/\/doi.org\/10.1002\/uog.14917","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"2015-03-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-05-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-06-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}