{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T23:16:33Z","timestamp":1782774993731,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,7]],"date-time":"2016-01-07T00:00:00Z","timestamp":1452124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet & Gyne"],"published-print":{"date-parts":[[2016,2]]},"abstract":"ABSTRACT<\/jats:title>Objective<\/jats:title>To investigate the potential value of biophysical and biochemical markers at 30\u201334 weeks' gestation in the prediction of adverse perinatal outcome.<\/jats:p><\/jats:sec>Methods<\/jats:title>This was a screening study in 8268 singleton pregnancies at 30\u201334 weeks' gestation. Estimated fetal weight (EFW<\/jats:styled-content>), uterine artery (UtA<\/jats:styled-content>) pulsatility index (PI<\/jats:styled-content>), umbilical artery (UA<\/jats:styled-content>) PI<\/jats:styled-content>, fetal middle cerebral artery (MCA<\/jats:styled-content>) PI<\/jats:styled-content>, mean arterial pressure (MAP<\/jats:styled-content>), serum placental growth factor (PlGF<\/jats:styled-content>) and soluble fms\u2010like tyrosine kinase\u20101 (sFlt<\/jats:styled-content>\u20101) were measured. The detection rate (DR<\/jats:styled-content>) and false\u2010positive rate (FPR<\/jats:styled-content>) of screening by each biomarker were estimated for stillbirth, pre\u2010eclampsia, delivery of small\u2010for\u2010gestational\u2010age (SGA<\/jats:styled-content>) neonate, Cesarean section for fetal distress before or during labor, umbilical arterial cord blood pH<\/jats:styled-content> \u22647.0 or umbilical venous cord blood pH<\/jats:styled-content> \u22647.1, 5\u2010min Apgar score < 7 and admission to the neonatal unit (NNU<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>Multivariable regression analysis demonstrated that significant prediction of PE<\/jats:styled-content> was provided by PlGF<\/jats:styled-content>, sFlt<\/jats:styled-content>\u20101, MAP<\/jats:styled-content> and MCA\u2010PI<\/jats:styled-content>, with a DR<\/jats:styled-content> of 98% for PE<\/jats:styled-content> delivering < 37 weeks' gestation and 56% for those delivering \u2265 37 weeks, at a 10% FPR<\/jats:styled-content>. Prediction of SGA<\/jats:styled-content> was provided by EFW<\/jats:styled-content>, PlGF<\/jats:styled-content>, sFlt<\/jats:styled-content>\u20101, UtA\u2010PI<\/jats:styled-content>, UA\u2010PI<\/jats:styled-content> and MCA\u2010PI<\/jats:styled-content>, with a DR<\/jats:styled-content> of 88% for SGA<\/jats:styled-content> delivering < 37 and 51% for those delivering \u2265 37 weeks' gestation, at a 10% FPR<\/jats:styled-content>. Prediction of stillbirth was provided by EFW<\/jats:styled-content>, UtA\u2010PI<\/jats:styled-content> and MCA\u2010PI<\/jats:styled-content>, with DR<\/jats:styled-content> of 30% at 10% FPR<\/jats:styled-content>. Prediction of Cesarean section for fetal distress before labor was provided by EFW<\/jats:styled-content>, sFlt<\/jats:styled-content>\u20101, UtA\u2010PI<\/jats:styled-content> and UA\u2010PI<\/jats:styled-content>, with a DR<\/jats:styled-content> of 90% at a 10% FPR<\/jats:styled-content>. Prediction of fetal distress in labor was provided by EFW<\/jats:styled-content> and sFlt<\/jats:styled-content>\u20101, with a DR<\/jats:styled-content> of 16% at a 10% FPR<\/jats:styled-content>. There were no significant differences from the normal outcome group in any of the biomarkers for low cord blood pH<\/jats:styled-content>, low Apgar score or NNU<\/jats:styled-content> admission for cases other than those with PE<\/jats:styled-content> and\/or SGA<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>At 30\u201334 weeks' gestation, biomarkers of impaired placentation and fetal hypoxemia provide good prediction of PE<\/jats:styled-content>, SGA<\/jats:styled-content> and fetal distress before labor, but poor or no prediction of stillbirth and adverse events in labor or after birth. Copyright \u00a9 2015 ISUOG. Published by John Wiley & Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.14928","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T23:18:30Z","timestamp":1434755910000},"page":"194-202","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Biophysical and biochemical markers at 30\u201334 weeks' gestation in the prediction of adverse perinatal outcome"],"prefix":"10.1002","volume":"47","author":[{"given":"N.","family":"Vali\u00f1o","sequence":"first","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Giunta","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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