{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T06:09:06Z","timestamp":1760249346749},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T00:00:00Z","timestamp":1464912000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"German Society of Ultrasound in Medicine"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Postnatal outcome of fetuses with hypoplastic left heart syndrome (<jats:styled-content style=\"fixed-case\">HLHS<\/jats:styled-content>) is determined mainly by right ventricular function. Our study examines whether there are differences in right ventricular function during gestation of fetuses with <jats:styled-content style=\"fixed-case\">HLHS<\/jats:styled-content> compared with healthy fetuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective study was conducted including 20 fetuses with <jats:styled-content style=\"fixed-case\">HLHS<\/jats:styled-content> and 20 gestational age\u2010matched controls. Peak systolic and diastolic right ventricular free wall velocities were assessed using color tissue Doppler imaging (c\u2010<jats:styled-content style=\"fixed-case\">TDI<\/jats:styled-content>). Subsequently, isovolumic time intervals, ejection time (<jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>\u2032), E\u2032\/A\u2032 ratio and tissue Doppler\u2010derived myocardial performance index (<jats:styled-content style=\"fixed-case\">MPI<\/jats:styled-content>\u2032) were calculated. Possible changes to c\u2010<jats:styled-content style=\"fixed-case\">TDI<\/jats:styled-content> indices during the course of pregnancy in both the <jats:styled-content style=\"fixed-case\">HLHS<\/jats:styled-content> group and the control group were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Examination of right ventricular function revealed significantly lower E\u2032 velocities (13.6 <jats:italic>vs<\/jats:italic> 21.0 cm\/s; <jats:italic>P <\/jats:italic>= 0.017) and E\u2032\/A\u2032 ratios (0.55 <jats:italic>vs<\/jats:italic> 0.76; <jats:italic>P <\/jats:italic>= 0.012) and prolonged isovolumic contraction time (<jats:styled-content style=\"fixed-case\">ICT<\/jats:styled-content>\u2032) (57.0 <jats:italic>vs<\/jats:italic> 45.7 ms; <jats:italic>P <\/jats:italic>= 0.008) in the <jats:styled-content style=\"fixed-case\">HLHS<\/jats:styled-content> group compared with healthy fetuses. Furthermore, isovolumic relaxation time and <jats:styled-content style=\"fixed-case\">MPI<\/jats:styled-content>\u2032 increased significantly with gestational age in <jats:styled-content style=\"fixed-case\">HLHS<\/jats:styled-content> fetuses but not in controls. Values for systolic and diastolic peak velocities (E\u2032, A\u2032, S\u2032), <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>\u2032 and <jats:styled-content style=\"fixed-case\">ICT<\/jats:styled-content>\u2032 did not change significantly during gestation in either group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Right ventricular function in <jats:styled-content style=\"fixed-case\">HLHS<\/jats:styled-content> is altered as early as in fetal life, well before palliative surgery is performed. Future research should provide further insight into ventricular remodeling during gestation in cases of <jats:styled-content style=\"fixed-case\">HLHS<\/jats:styled-content>. Copyright \u00a9 2015 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.14940","type":"journal-article","created":{"date-parts":[[2015,7,3]],"date-time":"2015-07-03T15:58:13Z","timestamp":1435939093000},"page":"732-738","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Evaluation of right ventricular function in fetal hypoplastic left heart syndrome by color tissue Doppler imaging"],"prefix":"10.1002","volume":"47","author":[{"given":"O.","family":"Graupner","sequence":"first","affiliation":[{"name":"Division of Perinatal Medicine, Department of Obstetrics &amp; Gynecology University Hospital Gie\u00dfen and Marburg, Justus\u2010Liebig University  Gie\u00dfen Germany"},{"name":"Department of Obstetrics and Gynecology Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Enzensberger","sequence":"additional","affiliation":[{"name":"Division of Perinatal Medicine, Department of Obstetrics &amp; Gynecology University Hospital Gie\u00dfen and Marburg, Justus\u2010Liebig University  Gie\u00dfen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Wieg","sequence":"additional","affiliation":[{"name":"Division of Perinatal Medicine, Department of Obstetrics &amp; Gynecology University Hospital Gie\u00dfen and Marburg, Justus\u2010Liebig University  Gie\u00dfen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Willruth","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Prenatal Medicine University of Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Steinhard","sequence":"additional","affiliation":[{"name":"Fetal Cardiology, Heart &amp; Diabetes Center Ruhr University Bochum  North\u2010Rhine Westphalia Bad Oeynhausen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Gembruch","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Doelle","sequence":"additional","affiliation":[{"name":"Toshiba Medical Systems  Neuss Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Bahlmann","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology  B\u00fcrgerhospital Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Kawecki","sequence":"additional","affiliation":[{"name":"Division of Perinatal Medicine, Department of Obstetrics &amp; 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