{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T07:35:22Z","timestamp":1770536122911,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ultrasound Obstet Gynecol"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1002\/uog.15673","type":"journal-article","created":{"date-parts":[[2015,8,17]],"date-time":"2015-08-17T07:05:23Z","timestamp":1439795123000},"page":"61-65","source":"Crossref","is-referenced-by-count":37,"title":["Comparison between transdermal nitroglycerin and sildenafil citrate in intrauterine growth restriction: effects on uterine, umbilical and fetal middle cerebral artery pulsatility indices"],"prefix":"10.1002","volume":"48","author":[{"suffix":"Jr","given":"A.","family":"Trapani","sequence":"first","affiliation":[{"name":"Hospital of Federal University of Santa Catarina; Florian\u00f3polis SC Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. F.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology; Oakland University William Beaumont School of Medicine; Rochester MI USA"},{"name":"Department of Radiology; Oakland University William Beaumont School of Medicine; Rochester MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. F.","family":"Trapani","sequence":"additional","affiliation":[{"name":"University of Southern Santa Catarina, Medical School; Palho\u00e7a SC Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Franco","sequence":"additional","affiliation":[{"name":"Hospital of Federal University of Santa Catarina; Florian\u00f3polis SC Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. N.","family":"Galluzzo","sequence":"additional","affiliation":[{"name":"Hospital of Federal University of Santa Catarina; Florian\u00f3polis SC Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. M. S.","family":"Pires","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Medical Sciences, Federal University of Santa Catarina; Florianopolis SC Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,5]]},"reference":[{"key":"10.1002\/uog.15673-BIB0001|uog15673-cit-0001","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1097\/01.AOG.0000429658.85846.f9","article-title":"bulletin no. 134: fetal growth restriction. American College of Obstetricians and Gynecologists","volume":"121","author":"Practice","year":"2013","journal-title":"Obstet Gynecol"},{"key":"10.1002\/uog.15673-BIB0002|uog15673-cit-0002","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.ajog.2005.07.032","article-title":"Antenatal predictors of neonatal outcome in fetal growth restriction with absent end-diastolic flow in the umbilical artery","volume":"193","author":"Vergani","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"10.1002\/uog.15673-BIB0003|uog15673-cit-0003","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1097\/00003081-200606000-00008","article-title":"Perinatal outcome and later implications of intrauterine growth restriction","volume":"49","author":"Pallotto","year":"2006","journal-title":"Clin Obstet Gynecol"},{"key":"10.1002\/uog.15673-BIB0004|uog15673-cit-0004","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1056\/NEJM199312303292706","article-title":"The L-arginine-nitric oxide pathway","volume":"329","author":"Moncada","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1002\/uog.15673-BIB0005|uog15673-cit-0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2008.08.029","article-title":"The effects of sildenafil citrate (Viagra) on uterine blood flow and well being in the intrauterine growth-restricted fetus","volume":"200","author":"Miller","year":"2009","journal-title":"Am J Obstet Gynecol"},{"key":"10.1002\/uog.15673-BIB0006|uog15673-cit-0006","doi-asserted-by":"crossref","first-page":"205","DOI":"10.2165\/00003088-200342030-00001","article-title":"Clinical pharmacokinetics and pharmacodynamics of glyceryl trinitrate and its metabolites","volume":"42","author":"Hashimoto","year":"2003","journal-title":"Clin Pharmacokinet"},{"key":"10.1002\/uog.15673-BIB0007|uog15673-cit-0007","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/uog.8983","article-title":"Transdermal nitroglycerin in patients with severe pre-eclampsia with placental insufficiency: effect on uterine, umbilical and fetal middle cerebral artery resistance indices","volume":"38","author":"Trapani","year":"2011","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1002\/uog.15673-BIB0008|uog15673-cit-0008","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1210\/jc.2004-1831","article-title":"Sildenafil citrate (Viagra) enhances vasodilatation in fetal growth restriction","volume":"90","author":"Wareing","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/uog.15673-BIB0009|uog15673-cit-0009","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.neuroscience.2010.08.065","article-title":"Treatment with sildenafil prevents impairment of learning in rats born to pre-eclamptic mothers","volume":"171","author":"Cauli","year":"2010","journal-title":"Neuroscience"},{"key":"10.1002\/uog.15673-BIB0010|uog15673-cit-0010","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.ajog.2005.05.054","article-title":"Expression of phosphodiesterase 5 in maternal and fetal sheep","volume":"193","author":"Coppage","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"10.1002\/uog.15673-BIB0011|uog15673-cit-0011","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1148\/radiology.181.1.1887021","article-title":"In utero analysis of fetal growth: a sonographic weight standard","volume":"181","author":"Hadlock","year":"1991","journal-title":"Radiology"},{"key":"10.1002\/uog.15673-BIB0012|uog15673-cit-0012","first-page":"469","volume-title":"Ultrasonography in Obstetrics and Gynecology","volume":"1","author":"Bahlmann","year":"2005"},{"key":"10.1002\/uog.15673-BIB0013|uog15673-cit-0013","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.ajog.2004.09.019","article-title":"Reference ranges for serial measurements of umbilical artery Doppler indices in the second half of pregnancy","volume":"192","author":"Acharya","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"10.1002\/uog.15673-BIB0014|uog15673-cit-0014","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.ajog.2004.06.051","article-title":"Obstetric outcomes associated with increase in BMI category during pregnancy","volume":"191","author":"Kabiru","year":"2004","journal-title":"Am J Obstet Gynecol"},{"key":"10.1002\/uog.15673-BIB0015|uog15673-cit-0015","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3109\/10641950802601278","article-title":"A randomised, double-blinded, placebo-controlled study of the phosphodiesterase type 5 inhibitor sildenafil for the treatment of preeclampsia","volume":"28","author":"Samangaya","year":"2009","journal-title":"Hypertens Pregnancy"},{"key":"10.1002\/uog.15673-BIB0016|uog15673-cit-0016","first-page":"474","article-title":"Re: glyceryl trinitrate (GTN) patches are unsuitable in hypertensive pregnancy","volume":"41","author":"Davis","year":"2001","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"10.1002\/uog.15673-BIB0017|uog15673-cit-0017","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1046\/j.1469-0705.1999.14020101.x","article-title":"Nitric oxide donors in pregnancy: fetomaternal hemodynamic effects induced in mild pre-eclampsia and threatened preterm labor","volume":"14","author":"Luzi","year":"1999","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1002\/uog.15673-BIB0018|uog15673-cit-0018","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0002-9378(98)70264-9","article-title":"Effects of transdermal nitroglycerin on impedance to flow in the uterine, umbilical, and fetal middle cerebral arteries in pregnancies complicated by preeclampsia and intrauterine growth retardation","volume":"179","author":"Cacciatore","year":"1998","journal-title":"Am J Obstet Gynecol"},{"key":"10.1002\/uog.15673-BIB0019|uog15673-cit-0019","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S0301-2115(02)00429-3","article-title":"Nitric oxide donors: effects on fetoplacental blood flow","volume":"115","author":"K\u00e4hler","year":"2004","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1002\/uog.15673-BIB0020|uog15673-cit-0020","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/bcp.12301","article-title":"The nitric oxide pathway and possible therapeutic options in pre-eclampsia","volume":"78","author":"Johal","year":"2014","journal-title":"Br J Clin Pharmacol"},{"key":"10.1002\/uog.15673-BIB0021|uog15673-cit-0021","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/S0029-7844(95)80024-7","article-title":"Effects of nitroglycerin on the uterine and umbilical circulation in severe preeclampsia","volume":"86","author":"Grunewald","year":"1995","journal-title":"Obstet Gynecol"},{"key":"10.1002\/uog.15673-BIB0022|uog15673-cit-0022","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1081\/PRG-120028280","article-title":"The effect of glyceryl trinitrate on hypertension in women with severe preeclampsia, HELLP syndrome, and eclampsia","volume":"23","author":"Cetin","year":"2004","journal-title":"Hypertens Pregnancy"},{"key":"10.1002\/uog.15673-BIB0023|uog15673-cit-0023","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1046\/j.1469-0705.1998.12050334.x","article-title":"The efficacy and fetal-maternal cardiovascular effects of transdermal glyceryl trinitrate in the prophylaxis of pre-eclampsia and its complications: a randomized double-blind placebo-controlled trial","volume":"12","author":"Lees","year":"1998","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1002\/uog.15673-BIB0024|uog15673-cit-0024","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1055\/s-0032-1304823","article-title":"Effects of sildenafil in N\u03c9-nitro-L-arginine methyl ester-induced intrauterine growth restriction in a rat model","volume":"29","author":"Nassar","year":"2012","journal-title":"Am J Perinatol"},{"key":"10.1002\/uog.15673-BIB0025|uog15673-cit-0025","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1071\/RDv27n1Ab91","article-title":"Sildenafil citrate modifies fetoplacental development in a rabbit model of intrauterine growth restriction","volume":"27","author":"L\u00f3pez-Tello","year":"2014","journal-title":"Reprod Fertil Dev"},{"key":"10.1002\/uog.15673-BIB0026|uog15673-cit-0026","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1161\/HYPERTENSIONAHA.111.186270","article-title":"Sildenafil citrate rescues fetal growth in the catechol-O-methyl transferase knockout mouse model","volume":"59","author":"Stanley","year":"2012","journal-title":"Hypertension"},{"key":"10.1002\/uog.15673-BIB0027|uog15673-cit-0027","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1080\/01443610701194978","article-title":"A systematic review of experimental and clinical studies of sildenafil citrate for intrauterine growth restriction and pre-term labour","volume":"27","author":"Villanueva-Garc\u00eda","year":"2007","journal-title":"J Obstet Gynaecol"},{"key":"10.1002\/uog.15673-BIB0028|uog15673-cit-0028","doi-asserted-by":"crossref","first-page":"R397","DOI":"10.1152\/ajpregu.00216.2013","article-title":"Sildenafil attenuates placental ischemia-induced hypertension","volume":"305","author":"George","year":"2013","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1002\/uog.15673-BIB0029|uog15673-cit-0029","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3109\/10641963.2011.628730","article-title":"Endothelial dysfunction in the human umbilical artery due to preeclampsia can be prevented by sildenafil","volume":"34","author":"Karasu","year":"2012","journal-title":"Clin Exp Hypertens"},{"key":"10.1002\/uog.15673-BIB0030|uog15673-cit-0030","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.ajog.2003.12.024","article-title":"Effects of a phosphodiesterase-5 (PDE5) inhibitor on endothelium-dependent relaxation of myometrial small arteries","volume":"190","author":"Wareing","year":"2004","journal-title":"Am J Obstet Gynecol"},{"key":"10.1002\/uog.15673-BIB0031|uog15673-cit-0031","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1111\/j.1471-0528.2010.02879.x","article-title":"Sildenafil citrate therapy for severe early-onset intrauterine growth restriction","volume":"118","author":"Dadelszen","year":"2011","journal-title":"BJOG"},{"key":"10.1002\/uog.15673-BIB0032|uog15673-cit-0032","first-page":"168","article-title":"Sildenafil citrate in fetal growth restriction","volume":"15","author":"Panda","year":"2014","journal-title":"J Reprod Infertil"},{"key":"10.1002\/uog.15673-BIB0033|uog15673-cit-0033","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/uog.11142","article-title":"Resolution of high uterine artery pulsatility index and notching following sildenafil citrate treatment in a growth-restricted pregnancy","volume":"40","author":"Lin","year":"2012","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1002\/uog.15673-BIB0034|uog15673-cit-0034","first-page":"632","article-title":"Sildenafil citrate and uteroplacental perfusion in fetal growth restriction","volume":"17","author":"Dastjerdi","year":"2012","journal-title":"J Res Med Sci"},{"key":"10.1002\/uog.15673-BIB0035|uog15673-cit-0035","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/2046-4053-3-23","article-title":"STRIDER: Sildenafil Therapy In Dismal prognosis Early-onset intrauterine growth Restriction\u00a0-\u00a0a protocol for a systematic review with individual participant data and aggregate data meta-analysis and trial sequential analysis","volume":"3","author":"Ganzevoort","year":"2014","journal-title":"Syst Rev"}],"container-title":["Ultrasound in Obstetrics & Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.15673","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.15673","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/uog.15673","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,8,6]],"date-time":"2018-08-06T08:44:12Z","timestamp":1533545052000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/uog.15673"}},"subtitle":["GTN\/sildenafil in IUGR"],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,7]]}},"URL":"https:\/\/doi.org\/10.1002\/uog.15673","archive":["Portico"],"relation":{},"ISSN":["0960-7692"],"issn-type":[{"value":"0960-7692","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]}}}