{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T07:50:45Z","timestamp":1794124245574,"version":"4.8.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,11,8]],"date-time":"2015-11-08T00:00:00Z","timestamp":1446940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2015,12]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>To describe a new sign of cleft lip and palate (CLP<\/jats:styled-content>), the maxillary gap, which is visible in the mid\u2010sagittal plane of the fetal face used routinely for measurement of nuchal translucency thickness.<\/jats:p><\/jats:sec>Methods<\/jats:title>This was a retrospective study of stored images of the mid\u2010sagittal view of the fetal face at 11\u201313 weeks' gestation in 86 cases of CLP<\/jats:styled-content> and 86 normal controls. The images were examined to determine if a maxillary gap was present, in which case its size was measured.<\/jats:p><\/jats:sec>Results<\/jats:title>In 37 (43.0%) cases of CLP<\/jats:styled-content> the defect was isolated and in 49 (57.0%) there were additional fetal defects. In the isolated CLP<\/jats:styled-content> group, the diagnosis of facial cleft was made in the first trimester in nine (24.3%) cases and in the second trimester in 28 (75.7%). In the group with additional defects, the diagnosis of facial cleft was made in the first trimester in 46 (93.9%) cases and in the second trimester in three (6.1%). A maxillary gap was observed in 96% of cases of CLP<\/jats:styled-content> with additional defects, in 65% of those with isolated CLP<\/jats:styled-content> and in 7% of normal fetuses. There was a large gap (>1.5\u2009mm) or complete absence of signals from the maxilla in the midline in 69% of cases of CLP<\/jats:styled-content> with additional defects, in 35% of those with isolated CLP<\/jats:styled-content> and in none of the normal controls.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The maxillary gap is a new simple marker of possible CLP<\/jats:styled-content>, which could increase the detection rate of CLP<\/jats:styled-content>, especially in isolated cases. Copyright \u00a9 2015 ISUOG. Published by John Wiley & Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.15675","type":"journal-article","created":{"date-parts":[[2015,8,17]],"date-time":"2015-08-17T07:04:55Z","timestamp":1439795095000},"page":"665-669","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":91,"title":["Maxillary gap at 11\u201313 weeks' gestation: marker of cleft lip and palate"],"prefix":"10.1002","volume":"46","author":[{"given":"R.","family":"Chaoui","sequence":"first","affiliation":[{"name":"Center for Prenatal Diagnosis and Human Genetics Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Orosz","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. S.","family":"Heling","sequence":"additional","affiliation":[{"name":"Center for Prenatal Diagnosis and Human Genetics Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sarut\u2010Lopez","sequence":"additional","affiliation":[{"name":"Center for Prenatal Diagnosis and Human Genetics Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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