{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T17:52:37Z","timestamp":1791741157496,"version":"4.3.4"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T00:00:00Z","timestamp":1451952000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet & Gyne"],"published-print":{"date-parts":[[2016,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n \n Placental insufficiency contributes to the risk of stillbirth. Cerebroplacental ratio (\n CPR<\/jats:styled-content>\n ) is an emerging marker of placental insufficiency. The aim of this study was to evaluate the association of third\u2010trimester fetal\n CPR<\/jats:styled-content>\n , uterine artery (UtA) Doppler and estimated fetal weight (\n EFW<\/jats:styled-content>\n ) with stillbirth and perinatal death.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This was a retrospective cohort study including 2812 women with a singleton pregnancy who underwent an ultrasound scan in the third trimester.\n EFWs<\/jats:styled-content>\n were converted into centiles, and Doppler indices (UtA and\n CPR<\/jats:styled-content>\n ) were converted into multiples of the median (\n MoM<\/jats:styled-content>\n ), adjusting for gestational age. Regression analysis was performed to identify, and adjust for, potential confounders, and receiver\u2013operating characteristics (\n ROC<\/jats:styled-content>\n ) curve analysis was used to assess the predictive value.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n When adjusting for\n EFW<\/jats:styled-content>\n centile and UtA mean pulsatility index (\n UtA\u2010PI<\/jats:styled-content>\n )\n MoM<\/jats:styled-content>\n ,\n CPR\u2010MoM<\/jats:styled-content>\n remained an independent predictor of stillbirth (odds ratio (\n OR<\/jats:styled-content>\n ) = 0.003 (95%\n CI<\/jats:styled-content>\n , 0.00\u20130.11),\n P<\/jats:italic>\n = 0.003) and perinatal mortality (\n OR<\/jats:styled-content>\n = 0.001 (95%\n CI<\/jats:styled-content>\n , 0.00\u20130.03),\n P<\/jats:italic>\n < 0.001).\n UtA\u2010PI<\/jats:styled-content>\n \u2265 1.5\n MoM<\/jats:styled-content>\n was significantly associated with low\n CPR\u2010MoM<\/jats:styled-content>\n , even after adjusting for\n EFW<\/jats:styled-content>\n centile (\n OR<\/jats:styled-content>\n = 5.22 (95%\n CI<\/jats:styled-content>\n , 3.88\u20137.04),\n P<\/jats:italic>\n < 0.001) or small\u2010for\u2010gestational age (\n SGA<\/jats:styled-content>\n ;\n OR<\/jats:styled-content>\n = 4.73 (95%\n CI<\/jats:styled-content>\n , 3.49\u20136.41),\n P<\/jats:italic>\n < 0.001). These associations remained significant, even when excluding pregnancies with\n SGA<\/jats:styled-content>\n or including only cases in which Doppler indices were recorded at term (\n P<\/jats:italic>\n < 0.01). For prediction of stillbirth, the area under the\n ROC<\/jats:styled-content>\n curve, using a combination of these three parameters, was 0.88 (95%\n CI<\/jats:styled-content>\n , 0.77\u20130.99) with a sensitivity of 66.7%, specificity of 92.1%, positive likelihood ratio (\n LR<\/jats:styled-content>\n ) of 8.46 and negative\n LR<\/jats:styled-content>\n of 0.36.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Third\u2010trimester\n CPR<\/jats:styled-content>\n is an independent predictor of stillbirth and perinatal mortality. The role of UtA Doppler,\n CPR<\/jats:styled-content>\n and\n EFW<\/jats:styled-content>\n in assessing risk of adverse pregnancy outcome should be evaluated prospectively. Copyright \u00a9 2015 ISUOG. Published by John Wiley & Sons Ltd.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/uog.15729","type":"journal-article","created":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T10:26:20Z","timestamp":1441189580000},"page":"74-80","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":155,"title":["Value of third\u2010trimester cerebroplacental ratio and uterine artery Doppler indices as predictors of stillbirth and perinatal loss"],"prefix":"10.1002","volume":"47","author":[{"given":"A.","family":"Khalil","sequence":"first","affiliation":[{"name":"Fetal Medicine Unit, St George's Hospital St George's University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Morales\u2010Rosell\u00f3","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, St George's Hospital St George's University of London London 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