{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T22:27:50Z","timestamp":1787351270421,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Congenital cardiac malformations are commonly identified at perinatal autopsy, which can be challenging in fetuses of early gestation and in macerated fetuses. Our objective was to examine fetal complex congenital heart disease by microcomputed tomography (micro\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>), using standard autopsy as the gold standard.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this ethically approved study, <jats:italic>ex\u2010vivo<\/jats:italic> isolated fetal heart and fetal heart\u2010lung blocks underwent iodine preparation prior to micro\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>, and were fixed in formalin after the micro\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> examination. Images were acquired using a microfocus\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> scanner with individual specimen image optimization. Twenty\u2010one indices assessed normally at autopsy were evaluated for each dataset. Cardiac dissection was performed using a dissecting microscope within 24\u2009h of the micro\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We examined six fetal hearts, comprising five with complex congenital cardiac malformations at a gestational age of 17\u201323 weeks and an anatomically normal heart of 23\u2009weeks' gestation for reference. All specimens demonstrated excellent internal contrast at micro\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> examination, and the correct overall diagnosis was made in all cases. There was agreement for 114\/126 indices assessed on micro\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> and at autopsy dissection (overall concordance of 95.8% (95%\u2009<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 90.5\u201398.2%)). Micro\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> was particularly useful in the assessment of ventricular morphology in macerated fetuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Micro\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> of small <jats:italic>ex\u2010vivo<\/jats:italic> fetal specimens can provide highly accurate three\u2010dimensional rendering of complex congenital fetal heart disease. This approach represents a significant advance in postmortem imaging and confirms the potential of this technology for non\u2010invasive examination of small fetuses and organs. Copyright \u00a9 2015 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.15764","type":"journal-article","created":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T12:32:44Z","timestamp":1443443564000},"page":"58-64","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Clinical utility\u2009of postmortem microcomputed tomography\u2009of the fetal heart: diagnostic imaging <i>vs<\/i> macroscopic dissection"],"prefix":"10.1002","volume":"47","author":[{"given":"J. C.","family":"Hutchinson","sequence":"first","affiliation":[{"name":"Institute of Child Health, UCL  London UK"},{"name":"Department of Histopathology UCL Institute of Child Health &amp; Great Ormond Street Hospital for Children  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. J.","family":"Arthurs","sequence":"additional","affiliation":[{"name":"Institute of Child Health, UCL  London UK"},{"name":"Paediatric Radiology Great Ormond Street Hospital for Children NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. T.","family":"Ashworth","sequence":"additional","affiliation":[{"name":"Department of Histopathology UCL Institute of Child Health &amp; Great Ormond Street Hospital for Children  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. T.","family":"Ramsey","sequence":"additional","affiliation":[{"name":"Nikon Metrology  Tring UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Mifsud","sequence":"additional","affiliation":[{"name":"Institute of Child Health, UCL  London UK"},{"name":"Department of Histopathology UCL Institute of Child Health &amp; Great Ormond Street Hospital for Children  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. M.","family":"Lombardi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Studio Diagnostico Eco  Vimercate Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. J.","family":"Sebire","sequence":"additional","affiliation":[{"name":"Institute of Child Health, UCL  London UK"},{"name":"Department of Histopathology UCL Institute of Child Health &amp; Great Ormond Street Hospital for Children  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2010.166"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2803"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30120"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2007.00777.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10024-002-0008-y"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60134-8"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60913-2"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14948"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp511"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10079"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2012.03357.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2008.03.006"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.113.000279"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.109.918482"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21857"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4435"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13330"},{"key":"e_1_2_6_19_1","unstructured":"Human Tissue Act2004.https:\/\/www.hta.gov.uk\/codes-practice."},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2013.08.004"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.15764","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.15764","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.15764","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T17:28:31Z","timestamp":1696354111000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.15764"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,2]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1002\/uog.15764"],"URL":"https:\/\/doi.org\/10.1002\/uog.15764","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,2]]},"assertion":[{"value":"2015-09-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-09-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-12-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}