{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T05:47:51Z","timestamp":1726292871603},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,29]],"date-time":"2015-11-29T00:00:00Z","timestamp":1448755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the efficacy of topical lidocaine gel and intrauterine lidocaine infusion administered prior to saline contrast sonohysterography (<jats:styled-content style=\"fixed-case\">SCSH<\/jats:styled-content>) in reducing pain level during the procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a randomized, double\u2010blind, placebo controlled trial. We recruited 120 women scheduled to undergo <jats:styled-content style=\"fixed-case\">SCSH<\/jats:styled-content> and randomized them into one of three groups according to administration of gel and intrauterine infusion immediately prior to the procedure: (1) the \u2018lidocaine gel\u2019 group received 3\u2009<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> 2% lidocaine gel applied to the cervix and intrauterine infusion, using an infant feeding tube without balloon, of 5\u2009<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> normal saline; (2) the \u2018lidocaine infusion\u2019 group received 3\u2009<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> gel lubricant applied to the cervix and intrauterine infusion of 5\u2009<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> 2% lidocaine; (3) the placebo group received 3\u2009<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> gel lubricant applied to the cervix and intrauterine infusion of 5\u2009<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> normal saline. The tube was left in place for the <jats:styled-content style=\"fixed-case\">SCSH<\/jats:styled-content> procedure. The primary outcome measure was the overall pain level (on a scale of 0\u2013100) reported by the women during the <jats:styled-content style=\"fixed-case\">SCSH<\/jats:styled-content> procedure. Women also rated their pain levels at various other time points and an observer assessed visible signs of the women's discomfort during the procedure, producing a distress score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences among the three groups in baseline characteristics, volume of saline solution infused, tenaculum use and duration and difficulty level of the <jats:styled-content style=\"fixed-case\">SCSH<\/jats:styled-content> procedure. The median (range) pain scores during normal saline infusion for the <jats:styled-content style=\"fixed-case\">SCSH<\/jats:styled-content> procedure were 0 (0\u201365) in the placebo group, 2.5 (0\u201380) in the lidocaine gel group, and 0 (0\u201370) in the lidocaine infusion group. The pain scores at other time points, the overall pain score and the distress score were also comparable for the three groups. No significant adverse events were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">SCSH<\/jats:styled-content> performed with an infant feeding tube without balloon is associated with very low pain levels. Topical lidocaine gel application and intrauterine lidocaine infusion do not further reduce pain levels during <jats:styled-content style=\"fixed-case\">SCSH<\/jats:styled-content>. Copyright \u00a9 2015 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.15775","type":"journal-article","created":{"date-parts":[[2015,10,5]],"date-time":"2015-10-05T11:20:47Z","timestamp":1444044047000},"page":"17-21","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Randomized, controlled, double\u2010blind trial of topical lidocaine gel and intrauterine lidocaine infusion for pain relief during saline contrast sonohysterography"],"prefix":"10.1002","volume":"47","author":[{"given":"S. S. F.","family":"Yung","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Queen Mary Hospital The University of Hong Kong, Hong Kong Special Administrative Region  People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. F.","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Queen Mary Hospital The University of Hong Kong, Hong Kong Special Administrative Region  People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. T.","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Queen Mary Hospital The University of Hong Kong, Hong Kong Special Administrative Region  People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. C. Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Queen Mary Hospital The University of Hong Kong, Hong Kong Special Administrative Region  People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. H. W.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Queen Mary Hospital The University of Hong Kong, Hong Kong Special Administrative Region  People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. C.","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Queen Mary Hospital The University of Hong Kong, Hong Kong Special Administrative Region  People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. H. Y.","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Queen Mary Hospital The University of Hong Kong, Hong Kong Special Administrative Region  People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.OGX.0000094386.63363.D7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2002.01478.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)01541-7"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2007.02.007"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del023"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000295865.93719.3f"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(01)01941-0"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c1130"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-012-2515-z"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000247645.52211.41"},{"key":"e_1_2_6_12_1","first-page":"CD006712","article-title":"Pain control in first trimester surgical abortion","author":"Renner RM","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(95)00463-7"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1999.tb08274.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016349.2010.499444"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2005.00812.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/104053"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)03362-9"},{"key":"e_1_2_6_19_1","first-page":"CD006106","article-title":"Pain relief in hysterosalpingography","author":"Ahmad G","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2014.09.035"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del517"},{"key":"e_1_2_6_22_1","doi-asserted-by":"crossref","first-page":"42390","DOI":"10.5539\/gjhs.v7n4p399","article-title":"Lidocaine\u2010prilocaine cream as analgesia for IUD insertion: a prospective, randomized, controlled, triple blinded study","volume":"7","author":"Tavakolian S","year":"2015","journal-title":"Glob J Health Sci"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000127981.53911.0e"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200003000-00006"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000319240"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.15775","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.15775","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.15775","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T17:28:24Z","timestamp":1696354104000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.15775"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,29]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1002\/uog.15775"],"URL":"https:\/\/doi.org\/10.1002\/uog.15775","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,29]]},"assertion":[{"value":"2015-07-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-09-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-11-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}