{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T05:17:45Z","timestamp":1787462265277,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,3,16]],"date-time":"2016-03-16T00:00:00Z","timestamp":1458086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet & Gyne"],"published-print":{"date-parts":[[2016,4]]},"abstract":"ABSTRACT<\/jats:title>Objectives<\/jats:title>Use of recent antenatal screening guidelines for cardiac abnormalities has increased fetal diagnoses of right aortic arch (RAA<\/jats:styled-content>). We aimed to establish the outcome of fetal RAA<\/jats:styled-content> without intracardiac abnormalities (ICA<\/jats:styled-content>) to guide postnatal management.<\/jats:p><\/jats:sec>Methods<\/jats:title>In the retrospective cohort part of our study, outcome measures were rates of chromosomal abnormalities, 22q11.2 deletion, fetal extracardiac abnormalities (ECA<\/jats:styled-content>), postnatal ICA<\/jats:styled-content> and ECA<\/jats:styled-content>, and symptoms of and surgery for vascular ring. A systematic review and meta\u2010analysis was also performed; results are reported as proportions. Kaplan\u2013Meier analysis of vascular ring cases with surgery as endpoint was performed.<\/jats:p><\/jats:sec>Results<\/jats:title>Our cohort included 86 cases; 41 had a vascular ring. Rates of chromosomal abnormalities, 22q11.2 deletion and fetal ECA<\/jats:styled-content> were 14.1%, 6.4% and 17.4%, respectively. Sixteen studies including our cohort (312 fetuses) were included in the systematic review. Overall rates of chromosomal abnormalities and 22q11.2 deletion were 9.0% (95% CI<\/jats:styled-content>, 6.0\u201312.5%) and 6.1% (95% CI<\/jats:styled-content>, 3.6\u20139.3%), whilst the respective rates for cases with no ECA<\/jats:styled-content> were 4.6% (95% CI<\/jats:styled-content>, 2.3\u20137.8%) and 5.1% (95% CI<\/jats:styled-content>, 2.4\u20138.6%). ECA<\/jats:styled-content> were seen in 14.6% (95% CI<\/jats:styled-content>, 10.6\u201319.0%) prenatally and in 4.0% (95% CI<\/jats:styled-content>, 1.5\u20137.6%) after birth. Postnatal ICA<\/jats:styled-content> were identified in 5.0% (95% CI<\/jats:styled-content>, 2.7\u20137.9%). Rate of symptoms of vascular rings (follow\u2010up \u2265 24 months postpartum) was 25.2% (95% CI<\/jats:styled-content>, 16.6\u201335.0%), and 17.1% (95% CI<\/jats:styled-content>, 9.9\u201325.7%) had surgery. Two\u2010year freedom from surgery was 83.0% (95% CI<\/jats:styled-content>, 74.3\u201390.1%).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Fetal RAA<\/jats:styled-content> without ICA<\/jats:styled-content> is more frequently associated with ECA<\/jats:styled-content> than with chromosomal abnormalities. Most cases, however, are isolated. Vascular\u2010ring symptoms occur in about 25% of cases. Postnatal surveillance is required mainly in the first 2 years after delivery. Copyright \u00a9 2015 ISUOG. Published by John Wiley & Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.15805","type":"journal-article","created":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T08:34:57Z","timestamp":1446453297000},"page":"423-432","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["Fetuses with right aortic arch: a multicenter cohort study and meta\u2010analysis"],"prefix":"10.1002","volume":"47","author":[{"given":"F.","family":"D'Antonio","sequence":"first","affiliation":[{"name":"Fetal Medicine Unit, St George's University Hospital NHS Foundation Trust and Institute of Cardiovascular and Cell Sciences St George's, University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Khalil","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, St George's University Hospital NHS Foundation Trust and Institute of Cardiovascular and Cell Sciences St George's, University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Zidere","sequence":"additional","affiliation":[{"name":"King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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