{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T17:55:49Z","timestamp":1782755749594,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,3,7]],"date-time":"2016-03-07T00:00:00Z","timestamp":1457308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet & Gyne"],"published-print":{"date-parts":[[2016,4]]},"abstract":"ABSTRACT<\/jats:title>Objective<\/jats:title>To examine the distribution of maternal serum placental growth factor (PlGF<\/jats:styled-content>) at 12, 22, 32 and 36 weeks' gestation in singleton pregnancies which develop pre\u2010eclampsia (PE<\/jats:styled-content>) and examine the performance of this biomarker in screening for PE<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Serum PlGF<\/jats:styled-content> was measured in 40 212 cases at 11\u201313 weeks, in 10 282 cases at 19\u201324 weeks, in 10 400 at 30\u201334 weeks and 4043 at 35\u201337 weeks. Bayes' theorem was used to combine the a\u2010priori<\/jats:italic> risk from maternal characteristics and medical history with serum PlGF<\/jats:styled-content>. The performance of screening for PE<\/jats:styled-content> requiring delivery < 32, at 32 + 0 to 36 + 6 and \u2265 37 weeks' gestation was estimated.<\/jats:p><\/jats:sec>Results<\/jats:title>In pregnancies that developed PE<\/jats:styled-content>, serum PlGF<\/jats:styled-content> was decreased and the separation in multiples of the median (MoM<\/jats:styled-content>) values from normal was greater with earlier, compared to later, gestational age at which delivery for PE<\/jats:styled-content> became necessary. Additionally, the slope of the regression lines of PlGF MoM<\/jats:styled-content> with gestational age at delivery in pregnancies that developed PE<\/jats:styled-content> increased with advancing gestational age at screening. The detection rates (DRs<\/jats:styled-content>), at a false\u2010positive rate (FPR<\/jats:styled-content>) of 10%, for PE<\/jats:styled-content> delivering < 32 weeks were 79% and 97% with screening at 12 and 22 weeks, respectively. The DRs<\/jats:styled-content> for PE<\/jats:styled-content> delivering at 32 + 0 to 36 + 6 weeks were 57%, 65% and 90% with screening at 12, 22 and 32 weeks. The DRs<\/jats:styled-content> for PE<\/jats:styled-content> delivering \u2265 37 weeks were 40%, 37%, 54% and 64% with screening at 12, 22, 32 and 36 weeks, respectively.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The performance of combined screening with maternal factors, medical history and PlGF is superior in screening for early, compared to late, PE<\/jats:styled-content> and improves with advancing gestational age at screening. Copyright \u00a9 2015 ISUOG. Published by John Wiley & Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.15816","type":"journal-article","created":{"date-parts":[[2015,11,19]],"date-time":"2015-11-19T05:18:42Z","timestamp":1447910322000},"page":"472-477","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Maternal serum placental growth factor at 12, 22, 32 and 36 weeks' gestation in screening for pre\u2010eclampsia"],"prefix":"10.1002","volume":"47","author":[{"given":"A.","family":"Tsiakkas","sequence":"first","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Cazacu","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Wright","sequence":"additional","affiliation":[{"name":"Institute of Health Research University of Exeter Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Wright","sequence":"additional","affiliation":[{"name":"Institute of Health Research University of Exeter Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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