{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T17:55:47Z","timestamp":1782755747864,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,3,9]],"date-time":"2016-03-09T00:00:00Z","timestamp":1457481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet & Gyne"],"published-print":{"date-parts":[[2016,4]]},"abstract":"ABSTRACT<\/jats:title>Objective<\/jats:title>To examine the distribution of maternal serum soluble fms\u2010like tyrosine kinase\u20101 (sFlt<\/jats:styled-content>\u20101) at 12, 22, 32 and 36 weeks' gestation in singleton pregnancies that develop pre\u2010eclampsia (PE<\/jats:styled-content>) and examine the performance of this biomarker in screening for PE<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Serum sFlt<\/jats:styled-content>\u20101 was measured in 7066 cases at 11\u201313 weeks, 8079 cases at 19\u201324 weeks, 8472 at 30\u201334 weeks and 4043 at 35\u201337 weeks. Bayes' theorem was used to combine the a\u2010priori<\/jats:italic> risk from maternal characteristics and medical history with serum levels of sFlt<\/jats:styled-content>\u20101. The performance of screening for PE<\/jats:styled-content> in women requiring delivery < 32, between 32 + 0 and 36 + 6 and \u2265 37 weeks' gestation was estimated.<\/jats:p><\/jats:sec>Results<\/jats:title>In pregnancies that developed PE<\/jats:styled-content>, serum sFlt<\/jats:styled-content>\u20101 was increased and the separation in multiples of the median (MoM<\/jats:styled-content>) values from normal was greater with earlier, compared to later, gestational age at which delivery for PE<\/jats:styled-content> became necessary. In pregnancies that developed PE<\/jats:styled-content>, the slope of the regression lines of sFlt<\/jats:styled-content>\u20101 MoM<\/jats:styled-content> with gestational age at delivery increased with advancing gestational age at screening. Measurement of sFlt<\/jats:styled-content>\u20101 at 11\u201313 weeks did not improve the prediction of PE<\/jats:styled-content> achieved by maternal factors alone, sFlt<\/jats:styled-content>\u20101 at 19\u201324 weeks improved the prediction of PE<\/jats:styled-content> delivering < 37 weeks but not for PE<\/jats:styled-content> delivering \u2265 37 weeks, sFlt<\/jats:styled-content>\u20101 at 30\u201334 weeks improved the prediction of PE<\/jats:styled-content> delivering < 37 and PE<\/jats:styled-content> delivering \u2265 37 weeks and sFlt<\/jats:styled-content>\u20101 at 35\u201337 weeks improved the prediction of PE<\/jats:styled-content> delivering \u2265 37 weeks. The detection rates (DRs<\/jats:styled-content>), at a false\u2010positive rate (FPR<\/jats:styled-content>) of 10%, of PE<\/jats:styled-content> delivering < 32 weeks were 52% and 65% with screening at 12 and 22 weeks, respectively. The DRs<\/jats:styled-content> for PE<\/jats:styled-content> delivering between 32 + 0 and 36 + 6 weeks were 44%, 44% and 93% with screening at 12, 22 and 32 weeks. The DR<\/jats:styled-content> for PE<\/jats:styled-content> delivering \u2265 37 weeks were 37%, 37%, 52% and 69% with screening at 12, 22, 32 and 36 weeks, respectively.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The performance of combined screening with maternal factors, medical history and serum sFlt<\/jats:styled-content>\u20101 is superior for detection of early, compared to late, PE<\/jats:styled-content> and improves with advancing gestational age at screening. Copyright \u00a9 2015 ISUOG. Published by John Wiley & Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.15817","type":"journal-article","created":{"date-parts":[[2015,11,19]],"date-time":"2015-11-19T05:21:21Z","timestamp":1447910481000},"page":"478-483","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Maternal serum soluble fms\u2010like tyrosine kinase\u20101 at 12, 22, 32 and 36 weeks' gestation in screening for pre\u2010eclampsia"],"prefix":"10.1002","volume":"47","author":[{"given":"A.","family":"Tsiakkas","sequence":"first","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Mendez","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Wright","sequence":"additional","affiliation":[{"name":"Institute of Health Research University of Exeter Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Wright","sequence":"additional","affiliation":[{"name":"Institute of Health Research University of Exeter Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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