{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T07:23:06Z","timestamp":1771917786551,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T00:00:00Z","timestamp":1457395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet & Gyne"],"published-print":{"date-parts":[[2016,4]]},"abstract":"ABSTRACT<\/jats:title>Objective<\/jats:title>To examine the distribution of maternal serum alpha\u2010fetoprotein (AFP<\/jats:styled-content>) at 12, 22 and 32 weeks' gestation in singleton pregnancies which develop pre\u2010eclampsia (PE<\/jats:styled-content>) and examine the performance of this biomarker in screening for PE<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Serum AFP<\/jats:styled-content> was measured in 17 071 cases at 11\u201313 weeks, in 8583 cases at 19\u201324 weeks and 8609 cases at 30\u201334 weeks' gestation. Bayes' theorem was used to combine the a\u2010priori<\/jats:italic> risk from maternal characteristics and medical history with AFP<\/jats:styled-content>. The performance of screening for PE<\/jats:styled-content> requiring delivery < 32, at 32 + 0 to 36 + 6, < 37 and \u2265 37 weeks' gestation was estimated.<\/jats:p><\/jats:sec>Results<\/jats:title>In pregnancies that developed PE<\/jats:styled-content>, serum AFP<\/jats:styled-content> multiples of the median (MoM<\/jats:styled-content>) was increased at 11\u201313 and 19\u201324 weeks' gestation, but not at 30\u201334 weeks, and the values were inversely related to gestational age at delivery. Combined screening with maternal factors and serum AFP<\/jats:styled-content> improved the prediction provided by maternal factors alone for PE<\/jats:styled-content> delivering < 37 weeks, but not for PE<\/jats:styled-content> delivering \u2265 37 weeks. The performance of screening for preterm PE<\/jats:styled-content> was better at 19\u201324 weeks than at 11\u201313 weeks and the detection rate (DR<\/jats:styled-content>) for a given false\u2010positive rate (FPR<\/jats:styled-content>) was higher for PE<\/jats:styled-content> delivering < 32 weeks than for PE<\/jats:styled-content> delivering at 32 + 0 to 36 + 6 weeks. The DRs<\/jats:styled-content>, at 10% FPR<\/jats:styled-content>, of combined screening at 11\u201313 weeks for PE<\/jats:styled-content> delivering < 32 and at 32 + 0 to 36 + 6 weeks were 54% and 45%, respectively, and these improved to 72% and 53% with screening at 19\u201324 weeks.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Measurement of serum AFP<\/jats:styled-content> at 11\u201313 and 19\u201324 weeks' gestation improves the prediction of preterm PE<\/jats:styled-content> provided by maternal factors alone. Copyright \u00a9 2015 ISUOG. Published by John Wiley & Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.15818","type":"journal-article","created":{"date-parts":[[2015,11,19]],"date-time":"2015-11-19T05:21:22Z","timestamp":1447910482000},"page":"466-471","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Maternal serum alpha\u2010fetoprotein at 12, 22 and 32 weeks' gestation in screening for pre\u2010eclampsia"],"prefix":"10.1002","volume":"47","author":[{"given":"F. 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