{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T11:08:02Z","timestamp":1784200082314,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T00:00:00Z","timestamp":1475625600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2016,10]]},"abstract":"ABSTRACT<\/jats:styled-content><\/jats:title>Objective<\/jats:title>To examine the performance of first\u2010trimester ultrasound screening for trisomies 18 and 13, triploidy and Turner syndrome based on fetal nuchal translucency thickness (NT<\/jats:styled-content>), additional fetal ultrasound markers including anatomy of the nasal bone (NB<\/jats:styled-content>), blood flow across the tricuspid valve (TV<\/jats:styled-content>) and through the ductus venosus (DV<\/jats:styled-content>) and a detailed fetal anomaly scan at 11\u201313 weeks' gestation.<\/jats:p><\/jats:sec>Methods<\/jats:title>This was a retrospective case\u2010matched study involving pregnant women at 11\u201313 weeks' gestation. The study population consisted of fetuses with trisomy 18, trisomy 13, triploidy or Turner syndrome. For each fetus with an abnormal karyotype, 50 randomly selected euploid fetuses were added to the study population. In all cases, the crown\u2013rump length and NT<\/jats:styled-content> were measured. In addition NB<\/jats:styled-content>, TV<\/jats:styled-content> flow and DV<\/jats:styled-content> flow were examined. The summed risk for trisomies 21, 18 and 13 was computed based on: first, maternal age (MA<\/jats:styled-content>); second, MA<\/jats:styled-content> and fetal NT<\/jats:styled-content>; third, MA<\/jats:styled-content>, NT<\/jats:styled-content> and one of the markers NB<\/jats:styled-content>, TV<\/jats:styled-content> flow or DV<\/jats:styled-content> flow; fourth, MA<\/jats:styled-content>, NT<\/jats:styled-content> and all these markers combined; fifth, MA<\/jats:styled-content>, NT<\/jats:styled-content> and fetal anomalies; and, finally, MA<\/jats:styled-content>, NT<\/jats:styled-content>, all markers and fetal anomalies.<\/jats:p><\/jats:sec>Results<\/jats:title>The study population consisted of 4550 euploid and 91 aneuploid fetuses. Median NT<\/jats:styled-content> was 1.8\u2009mm in euploid fetuses and 4.8, 6.8, 1.8 and 10.0\u2009mm in fetuses with trisomy 18, trisomy 13, triploidy and Turner syndrome, respectively. The NB<\/jats:styled-content>, TV<\/jats:styled-content> flow and DV<\/jats:styled-content> flow were abnormal in 48 (1.1%), 34 (0.7%) and 99 (2.2%) euploid fetuses, respectively, and in 42 (46.2%), 31 (34.1%) and 62 (68.1%) aneuploid fetuses, respectively. At least one defect was found in 60 (1.3%) euploid and in 76 (83.5%) aneuploid fetuses. For a false\u2010positive rate of 3%, the detection rate for screening based on MA<\/jats:styled-content> and fetal NT<\/jats:styled-content> was 75.8%. It increased to 84.6\u201386.8% when including one of the additional ultrasound markers and it was 90.1% when all three markers were included. When screening was based on MA<\/jats:styled-content>, fetal NT<\/jats:styled-content> and a detailed anomaly scan, the detection rate was 94.5% and increased to 95.6% with the addition of NB<\/jats:styled-content>, TV<\/jats:styled-content> flow and DV<\/jats:styled-content> flow.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>A detailed anomaly scan at 11\u201313 weeks' gestation can identify about 95% of fetuses with trisomy 18, trisomy 13, triploidy and Turner syndrome. Copyright \u00a9 2015 ISUOG. Published by John Wiley & Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.15829","type":"journal-article","created":{"date-parts":[[2015,11,27]],"date-time":"2015-11-27T06:37:22Z","timestamp":1448606242000},"page":"446-451","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["First\u2010trimester screening for trisomies 18 and 13, triploidy and Turner syndrome by detailed early anomaly scan"],"prefix":"10.1002","volume":"48","author":[{"given":"P.","family":"Wagner","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Sonek","sequence":"additional","affiliation":[{"name":"Fetal Medicine Foundation USA Dayton OH USA"},{"name":"Division of Maternal Fetal Medicine Wright State University Dayton OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Hoopmann","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Abele","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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