{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T04:57:13Z","timestamp":1782536233607,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,12,10]],"date-time":"2016-12-10T00:00:00Z","timestamp":1481328000000},"content-version":"am","delay-in-days":92,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T00:00:00Z","timestamp":1473379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006190","name":"Research and Development","doi-asserted-by":"publisher","award":["ZonMw"],"award-info":[{"award-number":["ZonMw"]}],"id":[{"id":"10.13039\/100006190","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006190","name":"Research and Development","doi-asserted-by":"publisher","award":["project number 200320012"],"award-info":[{"award-number":["project number 200320012"]}],"id":[{"id":"10.13039\/100006190","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the accuracy and timing of diagnosis of fetal cleft lip with or without cleft palate (<jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\u2009\u00b1\u2009P) in the years following the introduction of a national screening program, and to assess the completeness and accuracy of information in The Netherlands Perinatal Registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A list was obtained of cases with a prenatal or postnatal diagnosis of <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\u2009\u00b1\u2009P from two fetal medicine units between 2008 and 2012. All cases of <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\u2009\u00b1\u2009P were included irrespective of the presence or absence of additional anomalies. Cases were included if the estimated date of delivery was between 1 January 2008 and 31 December 2012.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the study period, 330 cases of <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\u2009\u00b1\u2009P were identified, with a prevalence of 15 per 10\u2009000 pregnancies. The number of cases that were detected before 24\u2009weeks' gestation increased during the study period, while the rate of termination of pregnancy did not change significantly (<jats:italic>P<\/jats:italic>\u2009=\u20090.511). <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\u2009\u00b1\u2009P was isolated in 217 (66%) cases and karyotype was abnormal in 69 (21%) cases. In 5% of the cases in which <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\u2009\u00b1\u2009P seemed to be isolated during the 18\u201323\u2010week anomaly scan, postnatal array comparative genomic hybridization (array\u2010<jats:styled-content style=\"fixed-case\">CGH<\/jats:styled-content>) revealed an abnormal karyotype and 50% of these cases had major additional anomalies. Examination of data from The Netherlands Perinatal Registry demonstrated that in 37% of cases <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\u00b1P was not recorded in the pregnancy records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\u2009\u00b1\u2009P is increasingly being diagnosed prenatally, without a significant effect on the rate of pregnancy termination. Further improvement in the diagnostic accuracy may be achieved by advocating prenatal array\u2010<jats:styled-content style=\"fixed-case\">CGH<\/jats:styled-content> to reduce the frequency of unexpected  anomalies being diagnosed after birth. It is important that healthcare providers register accurately the presence or absence of anomalies in the birth records to ensure that, in the future, data from The Netherlands Perinatal Registry can be relied upon to monitor prevalence. Copyright \u00a9 2015 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.15834","type":"journal-article","created":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T11:00:02Z","timestamp":1449745202000},"page":"458-463","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Prevalence, diagnosis and outcome of cleft lip with or without cleft palate in The Netherlands"],"prefix":"10.1002","volume":"48","author":[{"given":"J. H.","family":"Fleurke\u2010Rozema","sequence":"first","affiliation":[{"name":"Department of Obstetrics, University Medical Centre Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"van de Kamp","sequence":"additional","affiliation":[{"name":"Department of Obstetrics University Medical Centre Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. K.","family":"Bakker","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, University Medical Centre Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Pajkrt","sequence":"additional","affiliation":[{"name":"Department of Obstetrics University Medical Centre Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. M.","family":"Bilardo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, University Medical Centre Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. J. M.","family":"Snijders","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, University Medical Centre Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2012-101013"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.100.2.180"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-008-9152-5"},{"key":"e_1_2_6_5_1","volume-title":"Structureel echoscopisch onderzoek (SEO)","author":"Nederlandse Vereniging voor Obstetrie en Gynaecologie"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7472"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13291"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8895"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5280"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1597\/09-021"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000334065"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.34343"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4001"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4563"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12546"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.5935\/1808-8694.20120018"},{"key":"e_1_2_6_17_1","first-page":"336","article-title":"The genetics of cleft lip and cleft palate","volume":"22","author":"Fraser FC","year":"1970","journal-title":"Am J Hum Genet"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2010.193599"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1597\/06-202.1"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4582"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000351135"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1763"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12575"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.15834","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.15834","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.15834","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/uog.15834","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/am-pdf\/10.1002\/uog.15834","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.15834","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T14:19:29Z","timestamp":1694873969000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.15834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,9]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1002\/uog.15834"],"URL":"https:\/\/doi.org\/10.1002\/uog.15834","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,9]]},"assertion":[{"value":"2015-08-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-11-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-09-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}