{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:24:01Z","timestamp":1787509441654,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,9,15]],"date-time":"2016-09-15T00:00:00Z","timestamp":1473897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To assess perinatal outcomes and intrauterine complications following fetal intervention for congenital heart disease (\n                      <jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A systematic review and meta\u2010analysis were performed following an electronic search of\n                      <jats:styled-content style=\"fixed-case\">PubMed<\/jats:styled-content>\n                      and Scopus databases (last searched August 2015). Perinatal outcomes that were assessed included fetal death, live birth, preterm delivery\u2009&lt;\u200937\u2009weeks' gestation and neonatal death. Intrauterine complications that were assessed included bradycardia requiring treatment and hemopericardium requiring drainage. Estimated proportions were reported as mean (95%\u2009\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      ). Inconsistency was assessed using the\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      statistic.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>An electronic search identified 2279 records, of which 29 studies (11 retrospective cohort and 18 case reports) were considered eligible for analysis. Fetal death after treatment of CHD by aortic valvuloplasty was reported in three studies, with a rate of 31% (95% CI, 9\u201360%), after pulmonary valvuloplasty in one study, with a rate of 25% (95% CI, 10\u201349%), after septoplasty in one study, with a rate of 14% (95% CI, 6\u201328%) and after pericardiocentesis and\/or pericardioamniotic shunt placement in 24 studies, with a rate of 29% (95% CI, 18\u201341%). Bradycardia requiring treatment was reported after aortic valvuloplasty in two studies, with a rate of 52% (95% CI, 16\u201387%), after pulmonary valvuloplasty in one study, with a rate of 44% (95% CI, 23\u201367%), and after septoplasty in one study, with a rate of 27% (95% CI, 15\u201343%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Current evidence on the effectiveness of prenatal intervention for CHD derives mostly from case reports and a few larger series; no study was randomized. Although the results of the meta\u2010analysis are encouraging in terms of perinatal survival, they should be interpreted with caution when comparing with procedures performed after delivery. Copyright \u00a9 2016 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.15867","type":"journal-article","created":{"date-parts":[[2016,1,22]],"date-time":"2016-01-22T09:04:38Z","timestamp":1453453478000},"page":"426-433","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Perinatal outcomes and intrauterine complications following fetal intervention for congenital heart disease: systematic review and meta\u2010analysis of observational studies"],"prefix":"10.1002","volume":"48","author":[{"given":"E.","family":"Araujo J\u00fanior","sequence":"first","affiliation":[{"name":"Department of Obstetrics Paulista School of Medicine\u00a0\u2013\u00a0Federal University of S\u00e3o Paulo (EPM\u2010UNIFESP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Tonni","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Prenatal Diagnostic Center Guastalla Civil Hospital  AUSL Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Baylor College of Medicine and Texas Children's Hospital Pavilion for Women  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Ruano","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Baylor College of Medicine and Texas Children's Hospital Pavilion for Women  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. P.","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ribeir\u00e3o Preto School of Medicine\u00a0\u2013\u00a0S\u00e3o Paulo University (FMRP\u2010USP)  Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,15]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01886-7"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2014.07.030"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2013.04.002"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.05.020"},{"key":"e_1_2_5_6_1","first-page":"148","article-title":"Successful outcome after prenatal treatment of a cardiac diverticulum with massive pericardial effusion","volume":"25","author":"Abi\u2010Nader K","year":"2009","journal-title":"J Ultrasound Med"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000236156"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-015-1193-6"},{"key":"e_1_2_5_9_1","first-page":"856","article-title":"Prenatal pericardiocentesis: its role in the management of intrapericardial teratoma","volume":"79","author":"Benatar A","year":"1992","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.65.5.256"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.48"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000089058"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000135471.17922.17"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)00733-5"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000144357.29279.54"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-013-0792-3"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.05.037"},{"key":"e_1_2_5_18_1","unstructured":"WellsGA SheaB O\u00b4ConnellD PetersonJ WelchV LososM TugwellP.The Newcastle\u2010Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta\u2010analyses. 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