{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:33:17Z","timestamp":1791307997705,"version":"4.3.1"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T00:00:00Z","timestamp":1464912000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Fondo de Investigaci\u00f3n Sanitaria","award":["06\/1213"],"award-info":[{"award-number":["06\/1213"]}]},{"name":"Fondo de Investigaci\u00f3n Sanitaria","award":["07\/1095"],"award-info":[{"award-number":["07\/1095"]}]},{"name":"Maternal and Child Network SAMID","award":["RD 08\/0072"],"award-info":[{"award-number":["RD 08\/0072"]}]},{"name":"Maternal and Child Network SAMID","award":["RD12\/0026"],"award-info":[{"award-number":["RD12\/0026"]}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To ascertain whether screening for pre\u2010eclampsia (PE) and intrauterine growth restriction (IUGR) by uterine artery (UtA) Doppler in the second trimester of pregnancy and targeted surveillance improve maternal and perinatal outcomes in an unselected population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a multicenter randomized open\u2010label controlled trial. At the routine second\u2010trimester anomaly scan, women were assigned randomly to UtA Doppler or non\u2010Doppler groups. Women with abnormal UtA Doppler were offered intensive surveillance at high\u2010risk clinics of the participating centers with visits every 4 weeks that included measurement of maternal blood pressure, dipstick proteinuria, fetal growth and Doppler examination. The primary outcome was a composite score for perinatal complications, defined as the presence of any of the following: PE, IUGR, spontaneous labor &lt; 37 weeks' gestation, placental abruption, stillbirth, gestational hypertension, admission to neonatal intensive care unit and neonatal complications. Secondary outcomes were a composite score for maternal complications (disseminated intravascular coagulation, maternal mortality, postpartum hemorrhage, pulmonary edema, pulmonary embolism, sepsis), and medical interventions (for example, corticosteroid administration and induction of labor) in patients developing placenta\u2010related complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 11 667 women were included in the study. Overall, PE occurred in 348 (3.0%) cases, early\u2010onset PE in 48 (0.4%), IUGR in 722 (6.2%), early\u2010onset IUGR in 93 (0.8%) and early\u2010onset PE with IUGR in 32 (0.3%). UtA mean pulsatility index &gt; 90<jats:sup>th<\/jats:sup> percentile was able to detect 59% of early\u2010onset PE and 60% of early\u2010onset IUGR with a false\u2010positive rate of 11.1%. When perinatal and maternal data according to assigned group (UtA Doppler <jats:italic>vs<\/jats:italic> non\u2010Doppler) were compared, no differences were found in perinatal or maternal complications. However, screened patients had more medical interventions, such as corticosteroid administration (relative risk (RR), 1.79 (95% CI, 1.4\u20132.3)) and induction of labor for IUGR (RR, 1.36 (95% CI, 1.07\u20131.72)). In women developing PE or IUGR, there was a trend towards fewer maternal complications (RR, 0.46 (95% CI, 0.19\u20131.11)).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Routine second\u2010trimester UtA Doppler ultrasound in an unselected population identifies approximately 60% of women at risk for placental complications; however, application of this screening test failed to improve short\u2010term maternal and neonatal morbidity and mortality. Copyright \u00a9 2016 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.15873","type":"journal-article","created":{"date-parts":[[2016,1,29]],"date-time":"2016-01-29T08:10:52Z","timestamp":1454055052000},"page":"680-689","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Do knowledge of uterine artery resistance in the second trimester and targeted surveillance improve maternal and perinatal outcome? UTOPIA study: a randomized controlled trial"],"prefix":"10.1002","volume":"47","author":[{"given":"B.","family":"Garc\u00eda","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Maternal\u2010Foetal Medicine Unit Vall d'Hebron University Hospital, Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Llurba","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Maternal\u2010Foetal Medicine Unit Vall d'Hebron University Hospital, Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Spanish Maternal and Child Health Network Retic (SAMID) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Valle","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Hospital Universitario Materno\u2013Infantil de Las Palmas de Gran Canaria  Las Palmas de Gran Canaria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. D.","family":"G\u00f3mez\u2010Roig","sequence":"additional","affiliation":[{"name":"Spanish Maternal and Child Health Network Retic (SAMID) Instituto de Salud Carlos III  Madrid Spain"},{"name":"Department of Obstetrics BCNnatal, Hospital Sant Joan de D\u00e8u  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Juan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Hospital Son Llatzer, Palma de Mallorca  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"P\u00e9rez\u2010Matos","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Hospital Universitario Materno\u2013Infantil de Las Palmas de Gran Canaria  Las Palmas de Gran Canaria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Spanish Maternal and Child Health Network Retic (SAMID) Instituto de Salud Carlos III  Madrid Spain"},{"name":"Department of Obstetrics BCNnatal, Hospital Sant Joan de D\u00e8u  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Garc\u00eda\u2010Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Hospital Universitario Materno\u2013Infantil de Las Palmas de Gran Canaria  Las Palmas de Gran Canaria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Alijotas\u2010Reig","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Maternal\u2010Foetal Medicine Unit Vall d'Hebron University Hospital, Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. T.","family":"Higueras","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Maternal\u2010Foetal Medicine Unit Vall d'Hebron University Hospital, Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Calero","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Maternal\u2010Foetal Medicine Unit Vall d'Hebron University Hospital, Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Goya","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Maternal\u2010Foetal Medicine Unit Vall d'Hebron University Hospital, Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"P\u00e9rez\u2010Hoyos","sequence":"additional","affiliation":[{"name":"Department of Statistics and Preventive Medicine Vall d'Hebron University Hospital, Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Carreras","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Maternal\u2010Foetal Medicine Unit Vall d'Hebron University Hospital, Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Spanish Maternal and Child Health Network Retic (SAMID) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Cabero","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Maternal\u2010Foetal Medicine Unit Vall d'Hebron University Hospital, Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Spanish Maternal and Child Health Network Retic (SAMID) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(99)00462-7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(80)90387-7"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1994.tb13182.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)91970-0"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2004.02.003"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh037"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1964.tb04270.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0960-7692.2001.00572.x"},{"key":"e_1_2_6_10_1","volume-title":"Antenatal care (NICE clinical guidelines 62)","author":"National Institute for Health and Care Excellence (NICE)","year":"2008"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641950109152635"},{"key":"e_1_2_6_12_1","unstructured":"FP Zuspan 1978 WHO Geneva Switzerland"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008363"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/275613"},{"key":"e_1_2_6_15_1","volume-title":"Control prenatal del embarazo normal","author":"SEGO protocolos","year":"2010"},{"key":"e_1_2_6_16_1","volume-title":"Protocolos de Medicina Materno\u2010Fetal (Perinatolog\u00eda)","author":"Cabero i Roura LI","year":"2013"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1999.13040225.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181e9322a"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2660"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.127977"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000338470"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4519"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5184"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60736-4"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13310"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1329181"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00131-2"}],"container-title":["Ultrasound in Obstetrics &amp; 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