{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T11:29:32Z","timestamp":1782646172907,"version":"3.54.5"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T00:00:00Z","timestamp":1473379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the maternal hemodynamic profile in women with a diagnosis of threatened preterm delivery (<jats:styled-content style=\"fixed-case\">TPD<\/jats:styled-content>) in order to understand the possible pathophysiologic mechanism leading to an increased lifetime risk for future cardiovascular disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with a diagnosis of <jats:styled-content style=\"fixed-case\">TPD<\/jats:styled-content> were enrolled and assessed using a non\u2010invasive method (<jats:styled-content style=\"fixed-case\">USCOM<\/jats:styled-content><jats:sup>\u00ae<\/jats:sup>) for the determination of hemodynamic parameters. Vaginal and rectal swabs were taken, cervical length, blood inflammatory indices, fetal blood\u2010vessel Doppler velocimetry were measured and gestational age at the time of delivery and neonatal outcomes were noted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 68 patients were enrolled and included in the analysis. The population was divided into two groups according to total vascular resistance (<jats:styled-content style=\"fixed-case\">TVR<\/jats:styled-content>): Group A with a <jats:styled-content style=\"fixed-case\">TVR<\/jats:styled-content> of \u2264\u20091000 dynes\u2009\u00d7\u2009s\/cm<jats:sup>5<\/jats:sup> (<jats:italic>n<\/jats:italic>\u2009=\u200948) and Group B with a <jats:styled-content style=\"fixed-case\">TVR<\/jats:styled-content> of &gt;\u20091000 dynes\u2009\u00d7\u2009s\/cm<jats:sup>5<\/jats:sup> (<jats:italic>n<\/jats:italic> = 20). C\u2010reactive protein (<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>) was higher in Group B than in Group A, suggesting a systemic inflammation status. Group B delivered earlier (32\u2009+\u20094\u2009weeks <jats:italic>vs<\/jats:italic> 38\u2009+\u20092\u2009weeks; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) and neonatal outcome was worse than in Group\u00a0A. Significantly lower values of cardiac output, stroke volume, peak velocity of flow, velocity time integral, minute distance, stroke volume index, cardiac index, stroke work, cardiac power, inotropy index and potential\u2010to\u2010kinetic energy ratio were observed in Group B than in Group A.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Women with a diagnosis of <jats:styled-content style=\"fixed-case\">TPD<\/jats:styled-content> showing <jats:styled-content style=\"fixed-case\">TVR<\/jats:styled-content> values of &gt;\u20091000 dynes\u2009\u00d7\u2009s\/cm<jats:sup>5<\/jats:sup> and elevated levels of <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> are at high risk of preterm delivery. An impaired maternal cardiovascular adaptation during pregnancy in these patients might suggest a possible higher risk for subsequent future cardiovascular disease. Copyright \u00a9 2016 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.15910","type":"journal-article","created":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T06:36:45Z","timestamp":1457419005000},"page":"491-495","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Preterm delivery and elevated maternal total vascular resistance: signs of suboptimal cardiovascular adaptation to pregnancy?"],"prefix":"10.1002","volume":"48","author":[{"given":"H.","family":"Valensise","sequence":"first","affiliation":[{"name":"Department of Bioimaging, Obstetrics and Gynecology, Policlinico Casilino Universita degli Studi di Roma Tor Vergata  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Farsetti","sequence":"additional","affiliation":[{"name":"Department of Bioimaging, Obstetrics and Gynecology, Policlinico Casilino Universita degli Studi di Roma Tor Vergata  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Lo Presti","sequence":"additional","affiliation":[{"name":"Department of Bioimaging, Obstetrics and Gynecology, Policlinico Casilino Universita degli Studi di Roma Tor Vergata  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Pisani","sequence":"additional","affiliation":[{"name":"Department of Bioimaging, Obstetrics and Gynecology, Policlinico Casilino Universita degli Studi di Roma Tor Vergata  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. M.","family":"Tiralongo","sequence":"additional","affiliation":[{"name":"Department of Bioimaging, Obstetrics and Gynecology, Policlinico Casilino Universita degli Studi di Roma Tor Vergata  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Gagliardi","sequence":"additional","affiliation":[{"name":"Department of Bioimaging, Obstetrics and Gynecology, Policlinico Casilino Universita degli Studi di Roma Tor Vergata  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Vasapollo","sequence":"additional","affiliation":[{"name":"Department of Bioimaging, Obstetrics and Gynecology, Policlinico Casilino Universita degli Studi di Roma Tor Vergata  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. P.","family":"Novelli","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ospedale San Sebastiano Martire  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60074-4"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.01120.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2009.02448.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2010.01120.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31820faaf8"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2009.00948.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aet118"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeu162"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aei054"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms150711324"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosissup.2004.03.002"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-956774"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2013.07.002"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2010.06.001"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.05.041"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.09.020"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.15910","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.15910","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T14:19:00Z","timestamp":1694873940000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.15910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,9]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1002\/uog.15910"],"URL":"https:\/\/doi.org\/10.1002\/uog.15910","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,9]]},"assertion":[{"value":"2015-12-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-03-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-09-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}