{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:42:04Z","timestamp":1785796924755,"version":"3.56.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet & Gyne"],"published-print":{"date-parts":[[2016,12]]},"abstract":"ABSTRACT<\/jats:title>Objectives<\/jats:title>To quantify the prevalence of chromosomal anomalies in fetuses with persistent left superior vena cava (PLSVC<\/jats:styled-content>), assess the strength of the association between PLSVC<\/jats:styled-content> and coarctation of the aorta and ascertain the diagnostic accuracy of antenatal ultrasound in correctly identifying isolated cases of PLSVC<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>MEDLINE<\/jats:styled-content>, EMBASE, CINHAL and the Cochrane databases were searched from the year 2000 onwards using combinations of keywords \u2018left superior vena cava\u2019 and \u2018outcome\u2019. Two authors reviewed all abstracts independently. Quality assessment of the included studies was performed using the Newcastle\u2013Ottawa Scale for cohort studies. The rates of the following outcomes were analyzed: chromosomal abnormalities; associated intracardiac anomalies (ICAs<\/jats:styled-content>) and extracardiac anomalies (ECAs<\/jats:styled-content>) diagnosed prenatally; additional ICAs<\/jats:styled-content> and ECAs<\/jats:styled-content> detected only at postnatal imaging or clinical evaluation but missed at prenatal imaging; and association of PLSVC<\/jats:styled-content> and coarctation of the aorta. Meta\u2010analyses of proportions were used to combine data.<\/jats:p><\/jats:sec>Results<\/jats:title>In total, 2708 articles were identified and 13 (n<\/jats:italic>\u2009=\u2009501) were included in the systematic review. Associated ICAs<\/jats:styled-content> and ECAs<\/jats:styled-content> were detected at the prenatal ultrasound examination or at a follow\u2010up assessment in 60.7% (95% CI<\/jats:styled-content>, 44.2\u201375.9%) and 37.8% (95% CI<\/jats:styled-content>, 31.0\u201344.8%) of cases, respectively. Chromosomal anomalies occurred in 12.5% (95% CI<\/jats:styled-content>, 9.0\u201316.4%) of cases in the overall population of fetuses with PLSVC<\/jats:styled-content> and in 7.0% (95% CI<\/jats:styled-content>, 2.7\u201313.0%) of isolated cases. Additional ICAs<\/jats:styled-content> and ECAs<\/jats:styled-content> were detected only after birth and missed at ultrasound in 2.4% (95% CI<\/jats:styled-content>, 0.5\u20135.8%) and 6.7% (95% CI<\/jats:styled-content>, 2.2\u201313.2%) of cases, respectively. Coarctation of the aorta was associated with isolated PLSVC<\/jats:styled-content> in 21.3% (95% CI<\/jats:styled-content>, 13.6\u201330.3%) of cases.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>PLSVC<\/jats:styled-content> is commonly associated with ICAs<\/jats:styled-content>, ECAs<\/jats:styled-content> and chromosomal anomalies. Fetuses with isolated PLSVC<\/jats:styled-content> should be followed up throughout pregnancy in order to rule out coarctation of the aorta. As most of the data in this review were derived from high\u2010risk pregnancies, the rate of associated abnormalities is likely to be higher than that in the general population of fetuses with PLSVC<\/jats:styled-content>, for which more data are needed.<\/jats:p><\/jats:sec>Revisi\u00f3n sistem\u00e1tica y metaan\u00e1lisis de la persistencia de la vena cava superior izquierda en la ecograf\u00eda prenatal: anomal\u00edas asociadas, precisi\u00f3n del diagn\u00f3stico y resultado postnatal<\/jats:bold><\/jats:p>RESUMEN<\/jats:bold><\/jats:p><\/jats:sec>Objetivos<\/jats:title>Cuantificar la prevalencia de anomal\u00edas cromos\u00f3micas en fetos con vena cava superior izquierda persistente (VCSIP<\/jats:styled-content>), evaluar la solidez de la asociaci\u00f3n entre la VCSIP<\/jats:styled-content> y la coartaci\u00f3n a\u00f3rtica, y determinar la precisi\u00f3n del diagn\u00f3stico de la ecograf\u00eda prenatal como m\u00e9todo para identificar correctamente casos aislados de VCSIP<\/jats:styled-content>.<\/jats:p><\/jats:sec>M\u00e9todos<\/jats:title>Se busc\u00f3 en las bases de datos de MEDLINE<\/jats:styled-content>, EMBASE<\/jats:styled-content>, CINHAL<\/jats:styled-content> y Cochrane art\u00edculos publicados desde el a\u00f1o 2000 en adelante, usando combinaciones de las palabras clave \u201cvena cava superior izquierda\u201d y \u201cresultado\u201d. Dos de los autores revisaron de forma independiente todos los res\u00famenes encontrados. La evaluaci\u00f3n de calidad de los estudios incluidos se realiz\u00f3 mediante la escala Newcastle\u2010Ottawa para estudios de cohortes. Se analizaron las tasas de los siguientes resultados: anomal\u00edas cromos\u00f3micas; anomal\u00edas intracard\u00edacas (AIC<\/jats:styled-content>) y anomal\u00edas extracard\u00edacas (AEC<\/jats:styled-content>) asociadas diagnosticadas prenatalmente; AIC<\/jats:styled-content> y AEC<\/jats:styled-content> adicionales detectadas s\u00f3lo en ecograf\u00edas postnatales o mediante evaluaci\u00f3n cl\u00ednica, pero no observadas en ecograf\u00edas prenatales; y la asociaci\u00f3n entre la VCSIP<\/jats:styled-content> y la coartaci\u00f3n a\u00f3rtica. Se utiliz\u00f3 un meta\u2010an\u00e1lisis de proporciones para combinar los datos.<\/jats:p><\/jats:sec>Resultados<\/jats:title>En total, se identificaron 2708 art\u00edculos y se incluyeron 13 (n\u2009=\u2009501) en la revisi\u00f3n sistem\u00e1tica. En la ecograf\u00eda prenatal o en una revisi\u00f3n de seguimiento se detectaron AIC<\/jats:styled-content> y AEC<\/jats:styled-content> asociadas en el 60,7% (IC<\/jats:styled-content> 95%, 44,2\u201375,9%) y el 37,8% (IC<\/jats:styled-content> 95%, 31,0\u201344,8%) de los casos, respectivamente. Se produjeron anomal\u00edas cromos\u00f3micas en el 12,5% (IC<\/jats:styled-content> 95%, 9,0\u201316,4%) de los casos en la poblaci\u00f3n general de fetos con VCSIP<\/jats:styled-content> y en el 7,0% (IC<\/jats:styled-content> 95%, 2,7\u201313,0%) de casos aislados. Las AIC<\/jats:styled-content> y AEC<\/jats:styled-content> adicionales s\u00f3lo se detectaron despu\u00e9s del nacimiento y en el 6,7% (IC<\/jats:styled-content> 95%, 2,2\u201313,2%) de los casos, respectivamente. La coartaci\u00f3n a\u00f3rtica se encontr\u00f3 asociada con la VCSIP<\/jats:styled-content> aislada en un 21,3% (IC<\/jats:styled-content> 95%, 13,6\u201330,3%) de los casos.<\/jats:p><\/jats:sec>Conclusiones<\/jats:title>La VCSIP<\/jats:styled-content> est\u00e1 com\u00fanmente asociada a AIC<\/jats:styled-content>, AEC<\/jats:styled-content> y anomal\u00edas cromos\u00f3micas. Los fetos con VCSIP<\/jats:styled-content> aislada deben ser objeto de seguimiento durante todo el embarazo, con el fin de descartar la coartaci\u00f3n a\u00f3rtica. Como la mayor\u00eda de los datos de esta revisi\u00f3n proceden de embarazos de alto riesgo, es probable que la tasa de anomal\u00edas asociadas sea m\u00e1s alta que la de la poblaci\u00f3n general de fetos con VCSIP<\/jats:styled-content>, por lo que se necesitan m\u00e1s datos.<\/jats:p><\/jats:sec>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.15914","type":"journal-article","created":{"date-parts":[[2016,3,12]],"date-time":"2016-03-12T20:36:08Z","timestamp":1457814968000},"page":"701-708","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Systematic review and meta\u2010analysis of persistent left superior vena cava on prenatal ultrasound: associated anomalies, diagnostic accuracy and postnatal outcome"],"prefix":"10.1002","volume":"48","author":[{"given":"S.","family":"Gustapane","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, SS. 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